Prototypical Stressors

Showing 1 to 25 of 855 Prototypical Stressors

ID	Prototypical Stressor Name	Associated Chemical(s): Name, CAS-RN, DTXSID	Associated AOPs

2	(2-ethylhexyl) hydrogen phthalate	MEHP, CAS-RN: 4376-20-9, DTXSID2025680	None
3	1-Methylsulfonyloxyethane	Ethyl methanesulfonate, CAS-RN: 62-50-0, DTXSID6025309	None
4	17beta-Estradiol	17beta-Estradiol, CAS-RN: 50-28-2, DTXSID0020573	3 AOPs 314: Binding to estrogen receptor (ER)-α in immune cells leading to exacerbation of systemic lupus erythematosus (SLE) 503: Activation of uterine estrogen receptor-alfa leading to endometrial adenocarcinoma, via epigenetic modulation 504: SULT1E1 inhibition leading to uterine adenocarcinoma via increased estrogen availability at target organ level
5	17beta-Trenbolone	17beta-Trenbolone, CAS-RN: 10161-33-8, DTXSID0034192	3 AOPs 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) 376: Androgen receptor agonism leading to male-biased sex ratio 496: Androgen receptor agonism leading to reproduction dysfunction （in zebrafish）
6	2(3H)-Benzothiazolethione		None
7	2-mercaptobenzothiazole	2-Mercaptobenzothiazole, CAS-RN: 149-30-4, DTXSID1020807	None
8	Aceytlsalicylic acid	Aspirin, CAS-RN: 50-78-2, DTXSID5020108	None
9	Allyl Alcohol	Allyl alcohol, CAS-RN: 107-18-6, DTXSID8020044	38: Protein Alkylation leading to Liver Fibrosis
10	Benzo(k)fluoranthene	Benzo(k)fluoranthene, CAS-RN: 207-08-9, DTXSID0023909	None
11	Bis(2-ethylhexyl) phthalate	Di(2-ethylhexyl) phthalate, CAS-RN: 117-81-7, DTXSID5020607	2 AOPs 37: PPARα activation leading to hepatocellular adenomas and carcinomas in rodents 307: Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring
12	Butyl 4-hydroxybenzoate	4-Hydroxybenzoic acid butyl ester, CAS-RN: 94-26-8, DTXSID3020209	None
13	Carbon tetrachloride	Carbon tetrachloride, CAS-RN: 56-23-5, DTXSID8020250	38: Protein Alkylation leading to Liver Fibrosis
14	Dibutyl phthalate	1,2-Benzenedicarboxylic acid, dibutyl ester, CAS-RN: 84-74-2, DTXSID2021781	3 AOPs 307: Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring 575: Decreased testosterone synthesis leading to increased nipple retention (NR) in male (rodent) offspring 570: Decreased testosterone synthesis leading to hypospadias in male (mammalian) offspring
15	Diclofenac sodium	Diclofenac sodium, CAS-RN: 15307-79-6, DTXSID3037208	2 AOPs 177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality 186: unknown MIE leading to renal failure and mortality
16	Diethyl nitrosamine	N-Nitrosodiethylamine, CAS-RN: 55-18-5, DTXSID2021028	None
17	Diethyl sulfate	Diethyl sulfate, CAS-RN: 64-67-5, DTXSID1024045	None
18	Dimethyl nitrosamine	N-Nitrosodimethylamine, CAS-RN: 62-75-9, DTXSID7021029	38: Protein Alkylation leading to Liver Fibrosis
19	Dimethyl sulfate	Dimethyl sulfate, CAS-RN: 77-78-1, DTXSID5024055	None
20	Dioxin and dioxin-like compounds	2,3,7,8-Tetrachlorodibenzo-p-dioxin, CAS-RN: 1746-01-6, DTXSID2021315 Acetamide, CAS-RN: 60-35-5, DTXSID7020005	None
21	Domoic acid	L-Domoic acid, CAS-RN: 14277-97-5, DTXSID20274180	None
22	Ethyl methanesulfonate	Ethyl methanesulfonate, CAS-RN: 62-50-0, DTXSID6025309	550: Increased LMNA gene mutation leading to heart failure
23	Ethyl nitrosourea	1-Ethyl-1-nitrosourea, CAS-RN: 759-73-9, DTXSID8020593	None
24	Ethyl-N'-nitro-N-nitrosoguanidine	N′-Ethyl-N-nitro-N-nitrosoguanidine, CAS-RN: 63885-23-4, DTXSID3020592	None
25	Ethylene thiourea	Ethylene thiourea, CAS-RN: 96-45-7, DTXSID5020601	271: Inhibition of thyroid peroxidase leading to impaired fertility in fish
26	Fadrozole	Fadrozole, CAS-RN: 102676-47-1, DTXSID5034141	3 AOPs 153: Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats 346: Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation 25: Aromatase inhibition leading to reproductive dysfunction