Prototypical Stressors

Showing 226 to 250 of 855 Prototypical Stressors

ID	Prototypical Stressor Name	Associated Chemical(s): Name, CAS-RN, DTXSID	Associated AOPs

227	alpha-tocopheryl succinate		None
228	3-aminopropanal		144: Endocytic lysosomal uptake leading to liver fibrosis
229	artesunate	Artesunate, CAS-RN: 88495-63-0, DTXSID3042681	144: Endocytic lysosomal uptake leading to liver fibrosis
230	naphtharazine		None
231	Fluoroquinolones:		555: Inhibition, Ether-a-go-go (ERG) Voltage-Gated Potassium Channel leading to heart failure
232	Iron compounds		None
233	sertraline	Sertraline, CAS-RN: 79617-96-2, DTXSID6023577	203: 5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline
234	norfluoxetine		203: 5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline
235	Dibenzo[B,F][1,4]Oxazepine		196: Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation
236	2-Chlorobenzalmalononitrile		196: Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation
237	Nitrotoluenes (hypothesized binding)		6: Antagonist binding to PPARα leading to body-weight loss
238	Methoxyfenozide	Methoxyfenozide, CAS-RN: 161050-58-4, DTXSID3032628	2 AOPs 4: Ecdysone receptor agonism leading to mortality via suppression of Ftz-f1 342: Ecdysone receptor hyperactivation leading to mortality via mis-timed activation of nuclear receptor cascade
239	Halofenozide	Halofenozide, CAS-RN: 112226-61-6, DTXSID4032619	2 AOPs 4: Ecdysone receptor agonism leading to mortality via suppression of Ftz-f1 342: Ecdysone receptor hyperactivation leading to mortality via mis-timed activation of nuclear receptor cascade
240	Chemical		205: AOP from chemical insult to cell death
241	20-hydroxyecdysone	20-Hydroxyecdysone, CAS-RN: 5289-74-7, DTXSID5040388	2 AOPs 4: Ecdysone receptor agonism leading to mortality via suppression of Ftz-f1 342: Ecdysone receptor hyperactivation leading to mortality via mis-timed activation of nuclear receptor cascade
242	Ponasterone A	Ponasterone A, CAS-RN: 13408-56-5, DTXSID0040595	2 AOPs 4: Ecdysone receptor agonism leading to mortality via suppression of Ftz-f1 342: Ecdysone receptor hyperactivation leading to mortality via mis-timed activation of nuclear receptor cascade
243	Chromafenozide	Chromafenozide, CAS-RN: 143807-66-3, DTXSID4057976	2 AOPs 4: Ecdysone receptor agonism leading to mortality via suppression of Ftz-f1 342: Ecdysone receptor hyperactivation leading to mortality via mis-timed activation of nuclear receptor cascade
244	Cyasterone		4: Ecdysone receptor agonism leading to mortality via suppression of Ftz-f1
245	Makisterone A		4: Ecdysone receptor agonism leading to mortality via suppression of Ftz-f1
246	Inokosterone	Inokosterone, CAS-RN: 15130-85-5, DTXSID40164756	4: Ecdysone receptor agonism leading to mortality via suppression of Ftz-f1
247	Ecdysone		4: Ecdysone receptor agonism leading to mortality via suppression of Ftz-f1
248	RH-5849		2 AOPs 4: Ecdysone receptor agonism leading to mortality via suppression of Ftz-f1 342: Ecdysone receptor hyperactivation leading to mortality via mis-timed activation of nuclear receptor cascade
249	2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)		9 AOPs 21: Aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2 455: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced impeded craniofacial development 456: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced cardiovascular toxicity 439: Activation of the AhR leading to metastatic breast cancer 458: AhR activation in the liver leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals 459: AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals 494: AhR activation leading to liver fibrosis 563: Aryl hydrocarbon Receptor (AHR) activation causes Premature Ovarian Insufficiency via Bax mediated apoptosis 578: AhR activation leading to cancer progression via immunosuppression
250	Polycyclic aromatic hydrocarbons (PAHs)		5 AOPs 131: Aryl hydrocarbon receptor activation leading to uroporphyria 397: Bulky DNA adducts leading to mutations 550: Increased LMNA gene mutation leading to heart failure 556: Decreased Na/K ATPase activity leading to heart failure 563: Aryl hydrocarbon Receptor (AHR) activation causes Premature Ovarian Insufficiency via Bax mediated apoptosis
251	TCPOBOP		107: Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat