Prototypical Stressors

Showing 251 to 275 of 855 Prototypical Stressors

ID	Prototypical Stressor Name	Associated Chemical(s): Name, CAS-RN, DTXSID	Associated AOPs

252	Silver nanoparticles		207: NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans
253	UV-activated Titanium dioxide nanoparticles		208: Janus kinase (JAK)/Signal transducer and activator of transcription (STAT) and Transforming growth factor (TGF)-beta pathways activation leading to reproductive failure
254	Silica nanoparticles		2 AOPs 209: Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP 481: AOPs of amorphous silica nanoparticles: ROS-mediated oxidative stress increased respiratory dysfunction and diseases.
255	Graphene oxide nanoparticles		2 AOPs 210: Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building 237: Substance interaction with lung resident cell membrane components leading to atherosclerosis
256	Polychlorinated dibenzodioxins		2 AOPs 152: Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity 150: Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF
257	Polybrominated diphenyl ethers		152: Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity
258	Isoflavones		152: Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity
259	Perflourinated chemicals		152: Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity
260	Phthalates		152: Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity
261	Tetrabromobisphenol A	3,3',5,5'-Tetrabromobisphenol A, CAS-RN: 79-94-7, DTXSID1026081	2 AOPs 152: Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity 504: SULT1E1 inhibition leading to uterine adenocarcinoma via increased estrogen availability at target organ level
262	Clonixin	Clonixin, CAS-RN: 17737-65-4, DTXSID2046121	152: Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity
263	Meclofenamic acid	Meclofenamic acid, CAS-RN: 644-62-2, DTXSID0048559	152: Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity
264	2,6-dinitro-p-cresol		152: Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity
265	Triclopyr	Triclopyr, CAS-RN: 55335-06-3, DTXSID0032497	152: Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity
266	B2,4,2',		None
267	5alpha-Dihydrotestosterone	5alpha-Dihydrotestosterone, CAS-RN: 521-18-6, DTXSID9022364	376: Androgen receptor agonism leading to male-biased sex ratio
268	n/a		None
269	Iodine deficiency		None
270	SSRI (Selective serotonin reuptake inhibitor)		3 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 226: SSRI (Selective serotonin reuptake inhibitor) to hypertension 568: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) leads to Inhibition, Feeding
271	Mental stress		403: combined unhealthy lifestyle factors leading to metabolic syndrome
272	Increase cortisone levels (induced by stress)		3 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 221: Mental stress to depression 222: Mental stress to agitation
273	Gamma radiation		9 AOPs 216: Deposition of energy leading to population decline via DNA strand breaks and follicular atresia 238: Deposition of energy leading to population decline via DNA strand breaks and oocyte apoptosis 299: Deposition of energy leading to population decline via DNA oxidation and follicular atresia 311: Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis 386: Deposition of ionizing energy leading to population decline via inhibition of photosynthesis 387: Deposition of ionising energy leading to population decline via mitochondrial dysfunction 388: Deposition of ionising energy leading to population decline via programmed cell death 396: Deposition of ionizing energy leads to population decline via impaired meiosis 330: Excessive reactive oxygen species production leading to mortality (4)
274	Ultraviolet B radiation		9 AOPs 331: Reactive oxygen species leading to growth inhibition via lipid peroxidation and cell death 327: Excessive reactive oxygen species production leading to mortality (1) 328: Excessive reactive oxygen species production leading to mortality (2) 329: Excessive reactive oxygen species production leading to mortality (3) 330: Excessive reactive oxygen species production leading to mortality (4) 389: Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis 388: Deposition of ionising energy leading to population decline via programmed cell death 386: Deposition of ionizing energy leading to population decline via inhibition of photosynthesis 387: Deposition of ionising energy leading to population decline via mitochondrial dysfunction
275	NonSteroidal Anti-Inflammatory Drugs (NSAID)		217: Gastric ulcer formation
276	Helicobacter pylori		217: Gastric ulcer formation