Prototypical Stressors

Showing 301 to 325 of 855 Prototypical Stressors

ID	Prototypical Stressor Name	Associated Chemical(s): Name, CAS-RN, DTXSID	Associated AOPs

302	EGFR ligand		None
303	Reactive oxygen species		5 AOPs 148: EGFR Activation Leading to Decreased Lung Function 149: Peptide Oxidation Leading to Hypertension 282: Adverse outcome pathway on photochemical toxicity initiated by light exposure 296: Oxidative DNA damage leading to chromosomal aberrations and mutations 462: Activation of reactive oxygen species leading the atherosclerosis
304	Tributyltin	Tributyltin, CAS-RN: 688-73-3, DTXSID0040709	2 AOPs 72: Epigenetic modification of PPARG leading to adipogenesis 561: Aromatase induction leading to estrogen receptor alpha activation via increased estradiol
305	Single walled carbon nanotubes		409: Frustrated phagocytosis leads to malignant mesothelioma
306	Multi-walled carbon nanotubes		409: Frustrated phagocytosis leads to malignant mesothelioma
307	Sodium metam		242: Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity
308	Dimethyl dithiocarbamate		242: Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity
309	Thiram	Bis(dimethylaminothiocarbonyl) disulfide, CAS-RN: 137-26-8, DTXSID5021332	242: Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity
310	Disulfiram	Tetraethylthiuram disulfide, CAS-RN: 97-77-8, DTXSID1021322	2 AOPs 242: Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity 436: Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries
311	Ferbam	Ferbam, CAS-RN: 14484-64-1, DTXSID8020624	242: Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity
312	Dazornet		242: Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity
313	Pyrolidine dithiocarbamate		242: Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity
314	Mancozeb	Mancozeb, CAS-RN: 8018-01-7, DTXSID0034695	242: Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity
315	Nabam-sodium	Nabam-sodium, CAS-RN: 142-59-6, DTXSID5020603	242: Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity
316	Ziram	Ziram, CAS-RN: 137-30-4, DTXSID0021464	242: Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity
317	Zineb	Zineb, CAS-RN: 12122-67-7, DTXSID5021465	242: Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity
318	Carbon nanotubes		3 AOPs 241: Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis 237: Substance interaction with lung resident cell membrane components leading to atherosclerosis 409: Frustrated phagocytosis leads to malignant mesothelioma
319	Acrolein	Acrolein, CAS-RN: 107-02-8, DTXSID5020023	2 AOPs 411: Oxidative stress Leading to Decreased Lung Function 424: Oxidative stress Leading to Decreased Lung Function via CFTR dysfunction
321	3,5-Dichlorophenol	3,5-Dichlorophenol, CAS-RN: 591-35-5, DTXSID2025006	2 AOPs 245: Reduction in photophosphorylation leading to growth inhibition in aquatic plants 263: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation
322	Tenofovir	Tenofovir, CAS-RN: 147127-20-6, DTXSID9040132	256: Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity
323	Tenofovir disoproxil fumarate	Tenofovir disoproxil fumarate, CAS-RN: 202138-50-9, DTXSID5050426	256: Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity
324	Adefovir	Adefovir, CAS-RN: 106941-25-7, DTXSID6046214	256: Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity
325	Adefovir dipivoxil	Adefovir dipivoxil, CAS-RN: 142340-99-6, DTXSID5046487	256: Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity
326	Cidofovir	Cidofovir, CAS-RN: 113852-37-2, DTXSID3043734	256: Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity
327	Aminoglycosides		257: Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity