Prototypical Stressors

Showing 26 to 50 of 855 Prototypical Stressors

ID	Prototypical Stressor Name	Associated Chemical(s): Name, CAS-RN, DTXSID	Associated AOPs

27	Indomethacin	1-(p-Chlorobenzoyl)-5-methoxy-2-methyl-Indole-3-acetic acid, CAS-RN: 53-86-1, DTXSID9020740	177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
28	Isopropyl methanesulfonate	Isopropyl methanesulfonate, CAS-RN: 926-06-7, DTXSID8031497	None
29	Kainic acid	Kainic acid, CAS-RN: 487-79-6, DTXSID7040526	None
30	Lead(II)		None
31	Lead(II) acetate trihydrate	Lead(II) acetate trihydrate, CAS-RN: 6080-56-4, DTXSID3031521	None
32	Letrozole	Letrozole, CAS-RN: 112809-51-5, DTXSID4023202 Fadrozole, CAS-RN: 102676-47-1, DTXSID5034141	2 AOPs 153: Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats 346: Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation
33	Maneb	Maneb, CAS-RN: 12427-38-2, DTXSID9020794	242: Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity
34	Mercaptobenzothiazole	2-Mercaptobenzothiazole, CAS-RN: 149-30-4, DTXSID1020807	2 AOPs 175: Thyroperoxidase inhibition leading to altered amphibian metamorphosis 159: Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation
35	Mercuric chloride	Mercuric chloride, CAS-RN: 7487-94-7, DTXSID5020811	2 AOPs 17: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory 492: Glutathione conjugation leading to reproductive dysfunction via oxidative stress
36	Mercury	Mercury, CAS-RN: 7439-97-6, DTXSID1024172	3 AOPs 552: Inhibiton of L-Type Calcium Channels leading to heart failure via QT interval prolongation and Torsades de Pointes (TdP) 556: Decreased Na/K ATPase activity leading to heart failure 558: Phosphodiesterase inhibition leading to heart failure
37	Methimazole	Methimazole, CAS-RN: 60-56-0, DTXSID4020820	5 AOPs 175: Thyroperoxidase inhibition leading to altered amphibian metamorphosis 159: Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation 42: Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 271: Inhibition of thyroid peroxidase leading to impaired fertility in fish 363: Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure
38	Methyl methanesulfonate	Methyl methanesulfonate, CAS-RN: 66-27-3, DTXSID7020845	None
39	Methyl-l-N'-nitro-N-nitroguanidine	Methylnitronitrosoguanidine, CAS-RN: 70-25-7, DTXSID2020846	None
40	Methylmercuric(II) chloride	Methylmercuric(II) chloride, CAS-RN: 115-09-3, DTXSID5020813	17: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory
41	Naproxen	Naproxen, CAS-RN: 22204-53-1, DTXSID4040686	None
42	Ochratoxin A	Ochratoxin A, CAS-RN: 303-47-9, DTXSID7021073	None
43	Organophosphates	Parathion, CAS-RN: 56-38-2, DTXSID7021100 Soman, CAS-RN: 96-64-0, DTXSID2031906	10 AOPs 405: Organo-Phosphate Chemicals induced inhibition of AChE leading to impaired cognitive function 450: Inhibition of AChE and activation of CYP2E1 leading to sensory axonal peripheral neuropathy and mortality 490: Co-activation of IP3R and RyR leads to reduced IQ and increased socio-economic burden through non-cholinergic mechanisms 543: Inhibition of neuropathy target esterase leading to delayed neuropathy via lysolecithin cell membrane integration 544: Inhibition of neuropathy target esterase leading to delayed neuropathy via increased inflammation 552: Inhibiton of L-Type Calcium Channels leading to heart failure via QT interval prolongation and Torsades de Pointes (TdP) 555: Inhibition, Ether-a-go-go (ERG) Voltage-Gated Potassium Channel leading to heart failure 556: Decreased Na/K ATPase activity leading to heart failure 560: Inhibition of Funny current (If) leading to Arrhythmias 562: HCN Channel Inhibition leading to Arrhythmias
44	Paraquat	Paraquat, CAS-RN: 4685-14-7, DTXSID3034799	593: Redox cycling of a chemical by mitochondria leads to degeneration of nigrostriatal dopaminergic neurons
45	Parathion	Parathion, CAS-RN: 56-38-2, DTXSID7021100	559: Inhibition of acetylcholinesterase (AChE) leading to arrhythmias
46	Phenanthrene	Phenanthrene, CAS-RN: 85-01-8, DTXSID6024254	None
47	Prochloraz	Prochloraz, CAS-RN: 67747-09-5, DTXSID4024270	346: Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation
48	Propylthiouracil	6-Propyl-2-thiouracil, CAS-RN: 51-52-5, DTXSID5021209	5 AOPs 175: Thyroperoxidase inhibition leading to altered amphibian metamorphosis 159: Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation 42: Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 271: Inhibition of thyroid peroxidase leading to impaired fertility in fish 363: Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure
49	Resorcinol	Resorcinol, CAS-RN: 108-46-3, DTXSID2021238 Tetraphenyl m-phenylene bis(phosphate), CAS-RN: 57583-54-7, DTXSID8069197	None
50	Rotenone	Rotenone, CAS-RN: 83-79-4, DTXSID6021248	3: Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits
51	Selected AHR Ligands		None