Prototypical Stressors

Showing 51 to 75 of 855 Prototypical Stressors

ID	Prototypical Stressor Name	Associated Chemical(s): Name, CAS-RN, DTXSID	Associated AOPs

52	Spironolactone	Spironolactone, CAS-RN: 52-01-7, DTXSID6034186	None
53	Thiouracil	Thiouracil, CAS-RN: 141-90-2, DTXSID4021347	None
54	Trimethyltin chloride	Trimethyltin chloride, CAS-RN: 1066-45-1, DTXSID6042496	None
55	Vatalanib	Vatalanib, CAS-RN: 212141-54-3, DTXSID2046919 Sunitinib malate, CAS-RN: 341031-54-7, DTXSID4046492	43: Disruption of VEGFR Signaling Leading to Developmental Defects
56	Ethylenethiourea	Ethylene thiourea, CAS-RN: 96-45-7, DTXSID5020601	None
57	Acetaminophen	Acetamide, CAS-RN: 60-35-5, DTXSID7020005 Acetaminophen, CAS-RN: 103-90-2, DTXSID2020006 Acetohexamide, CAS-RN: 968-81-0, DTXSID7020007	260: CYP2E1 activation and formation of protein adducts leading to neurodegeneration
58	Mercaptobenzole		None
59	Lead	Lead, CAS-RN: 7439-92-1, DTXSID2024161	8 AOPs 12: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging 499: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via disrupted neurotransmitter release 500: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis 552: Inhibiton of L-Type Calcium Channels leading to heart failure via QT interval prolongation and Torsades de Pointes (TdP) 555: Inhibition, Ether-a-go-go (ERG) Voltage-Gated Potassium Channel leading to heart failure 556: Decreased Na/K ATPase activity leading to heart failure 558: Phosphodiesterase inhibition leading to heart failure 560: Inhibition of Funny current (If) leading to Arrhythmias
60	Retinol	Retinol, CAS-RN: 68-26-8, DTXSID3023556	38: Protein Alkylation leading to Liver Fibrosis
61	Aflatoxin B1	Aflatoxin B1, CAS-RN: 1162-65-8, DTXSID9020035	397: Bulky DNA adducts leading to mutations
62	Benzidine	C.I. Azoic Diazo Component 112, CAS-RN: 92-87-5, DTXSID2020137	None
63	Thioacetamide	Thioacetamide, CAS-RN: 62-55-5, DTXSID9021340	38: Protein Alkylation leading to Liver Fibrosis
64	Mono(2-ethylhexyl) phthalate		457: Succinate dehydrogenase inhibition leading to increased insulin resistance through reduction in circulating thyroxine
65	Di(2-ethylhexyl) phthalate	Di(2-ethylhexyl) phthalate, CAS-RN: 117-81-7, DTXSID5020607	3 AOPs 457: Succinate dehydrogenase inhibition leading to increased insulin resistance through reduction in circulating thyroxine 575: Decreased testosterone synthesis leading to increased nipple retention (NR) in male (rodent) offspring 570: Decreased testosterone synthesis leading to hypospadias in male (mammalian) offspring
66	Perchlorate	Perchlorate, CAS-RN: 14797-73-0, DTXSID6024252	2 AOPs 176: Sodium Iodide Symporter (NIS) Inhibition leading to altered amphibian metamorphosis 54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment
67	Nitrate	Nitrate, CAS-RN: 14797-55-8, DTXSID5024217	54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment
68	Thiocyanate	Thiocyanate, CAS-RN: 302-04-5, DTXSID8047763	54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment
69	Dysidenin		54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment
70	Troglitazone	Troglitazone, CAS-RN: 97322-87-7, DTXSID8023719	163: PPARgamma activation leading to sarcomas in rats, mice, and hamsters
71	1-CHLORO-2,4- DINITROBENZENE	Glutathione, CAS-RN: 70-18-8, DTXSID6023101	None
72	Amitrole	Amitrole, CAS-RN: 61-82-5, DTXSID0020076	None
73	131-55-5		None
74	2,2',4,4'-Tetrahydroxybenzophenone	2,2',4,4'-Tetrahydroxybenzophenone, CAS-RN: 131-55-5, DTXSID5041306	2 AOPs 175: Thyroperoxidase inhibition leading to altered amphibian metamorphosis 152: Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity
75	Daidzein	7,4'-Dihydroxyisoflavone, CAS-RN: 486-66-8, DTXSID9022310	None
76	Genistein	Genistein, CAS-RN: 446-72-0, DTXSID5022308	167: Early-life estrogen receptor agonism leading to endometrial adenosquamous carcinoma via promotion of sine oculis homeobox 1 progenitor cells