Prototypical Stressors

Showing 826 to 850 of 855 Prototypical Stressors

ID	Prototypical Stressor Name	Associated Chemical(s): Name, CAS-RN, DTXSID	Associated AOPs

829	Oxadiazon	Oxadiazon, CAS-RN: 19666-30-9, DTXSID3024239	561: Aromatase induction leading to estrogen receptor alpha activation via increased estradiol
830	Metolachlor	Metolachlor, CAS-RN: 51218-45-2, DTXSID4022448	561: Aromatase induction leading to estrogen receptor alpha activation via increased estradiol
831	Cilobradine		562: HCN Channel Inhibition leading to Arrhythmias
832	4-bromo-2-(methylamino)-benzimidazole		562: HCN Channel Inhibition leading to Arrhythmias
833	N-Methyl-D-aspartic acid	N-Methyl-D-aspartic acid, CAS-RN: 6384-92-5, DTXSID8041082	475: Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons
834	1,1'-Ethane-1,2-diylbis(pentabromobenzene)	1,1'-Ethane-1,2-diylbis(pentabromobenzene), CAS-RN: 84852-53-9, DTXSID2052732	3 AOPs 564: DBDPE-induced inhibition of mitochondrial complex Ⅰ leading to population decline via neurotoxicity and metabotoxicity. 592: DBDPE-induced DNA strand breaks and LDH activity inhibition leading to population growth rate decline via energy metabolism disrupt and apoptosis 591: DBDPE-induced DNA damage increase in liver leading to Non-alcoholic fatty liver disease via liver steatosis and inhibition of regeneration
835	3,3',5,5'-Tetrabromobisphenol A	3,3',5,5'-Tetrabromobisphenol A, CAS-RN: 79-94-7, DTXSID1026081	565: 17β-Hydroxysteroid dehydrogenase 2, inhibition leading to activation, estrogen receptor alpha
836	7,12-Dimethylbenz(a)anthracene	7,12-Dimethylbenz(a)anthracene, CAS-RN: 57-97-6, DTXSID1020510	563: Aryl hydrocarbon Receptor (AHR) activation causes Premature Ovarian Insufficiency via Bax mediated apoptosis
837	Gluten		524: Gluten-driven immune activation leading to celiac disease in genetically predisposed individuals
838	Bacterial or viral Infections		524: Gluten-driven immune activation leading to celiac disease in genetically predisposed individuals
839	Tissue transglutaminase 2 (TG2) enzyme activity		524: Gluten-driven immune activation leading to celiac disease in genetically predisposed individuals
840	Redox status		504: SULT1E1 inhibition leading to uterine adenocarcinoma via increased estrogen availability at target organ level
841	calcium ionophore		None
842	CuO nanoparticles		590: Increase of intracellular copper leading to cuproptosis via interference with energy metabolism
843	Elesclomol		590: Increase of intracellular copper leading to cuproptosis via interference with energy metabolism
844	Wilson's disease		590: Increase of intracellular copper leading to cuproptosis via interference with energy metabolism
845	2,2',3,3',4,4',5,5',6,6'-Decabromodiphenyl ether	2,2',3,3',4,4',5,5',6,6'-Decabromodiphenyl ether, CAS-RN: 1163-19-5, DTXSID9020376	None
846	Picoxystrobin	Picoxystrobin, CAS-RN: 117428-22-5, DTXSID9047542	587: Inhibition of the mitochondrial complex III of nigro-striatal neurons leads to parkinsonian motor deficits
847	Muristerone A		342: Ecdysone receptor hyperactivation leading to mortality via mis-timed activation of nuclear receptor cascade
848	Cucurbitacin B		606: Ecdysone receptor antagonism leading to mortality via inhibition of chitin synthase 1
849	Cucurbitacin D		606: Ecdysone receptor antagonism leading to mortality via inhibition of chitin synthase 1
850	Deguelin	Deguelin, CAS-RN: 522-17-8, DTXSID10200231	3: Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits
851	Pyrimidifen	Pyrimidifen, CAS-RN: 105779-78-0, DTXSID9057925	3: Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits
852	Tebufenpyrad	Tebufenpyrad, CAS-RN: 119168-77-3, DTXSID0034223	3: Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits
853	Brusatol		615: Suppression of Keap1 cysteine oxidation leading to liver inflammation