Prototypical Stressors

Showing 126 to 150 of 855 Prototypical Stressors

ID	Prototypical Stressor Name	Associated Chemical(s): Name, CAS-RN, DTXSID	Associated AOPs

127	Nocodazole	Nocodazole, CAS-RN: 31430-18-9, DTXSID9031800	106: Chemical binding to tubulin in oocytes leading to aneuploid offspring
128	Benomyl	Benomyl, CAS-RN: 17804-35-2, DTXSID5023900	2 AOPs 106: Chemical binding to tubulin in oocytes leading to aneuploid offspring 561: Aromatase induction leading to estrogen receptor alpha activation via increased estradiol
129	Carbendazim	Carbendazim, CAS-RN: 10605-21-7, DTXSID4024729	None
130	Thiabendazole	Thiabendazole, CAS-RN: 148-79-8, DTXSID0021337	None
131	Vincristine	Vincristine, CAS-RN: 57-22-7, DTXSID1032278	None
132	Hydrocarbons, various		None
133	Phenobarbital	Phenobarbital, CAS-RN: 50-06-6, DTXSID5021122	2 AOPs 162: Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse 107: Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat
134	Dichloroacetic Acid	Dichloroacetic acid, CAS-RN: 79-43-6, DTXSID2020428	None
135	Cyp2f2 substrates		None
136	Vinclozalin		None
137	Flutamide	Flutamide, CAS-RN: 13311-84-7, DTXSID7032004	4 AOPs 345: Androgen receptor (AR) antagonism leading to decreased fertility in females 306: Androgen receptor (AR) antagonism leading to short anogenital distance (AGD) in male (mammalian) offspring 344: Androgen receptor (AR) antagonism leading to nipple retention (NR) in male (mammalian) offspring 477: Androgen receptor (AR) antagonism leading to hypospadias in male (mammalian) offspring
138	Bromocriptine	Bromocriptine, CAS-RN: 25614-03-3, DTXSID1022687	None
139	Propylene oxide		None
140	Nitisinone		None
141	Tembotrione	Tembotrione, CAS-RN: 335104-84-2, DTXSID5047037	None
142	Chloroform	Chloroform, CAS-RN: 67-66-3, DTXSID1020306	None
143	Androstenedione		None
144	Thiamethoxam	Thiamethoxam, CAS-RN: 153719-23-4, DTXSID2034962	None
145	Finasteride		3 AOPs 305: 5α-reductase inhibition leading to short anogenital distance (AGD) in male (mammalian) offspring 576: 5α-reductase inhibition leading to increased nipple retention (NR) in male (rodent) offspring 571: 5α-reductase inhibition leading to hypospadias in male (mammalian) offspring
146	SACCHARIN, CALCIUM SALT		None
147	Dibenzo-p-dioxin	Dibenzo-p-dioxin, CAS-RN: 262-12-4, DTXSID8020410	131: Aryl hydrocarbon receptor activation leading to uroporphyria
148	Polychlorinated biphenyl		5 AOPs 150: Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF 152: Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity 131: Aryl hydrocarbon receptor activation leading to uroporphyria 458: AhR activation in the liver leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals 459: AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals
149	Polychlorinated dibenzofurans		150: Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF
150	Hexachlorobenzene	Hexachlorobenzene, CAS-RN: 118-74-1, DTXSID2020682	131: Aryl hydrocarbon receptor activation leading to uroporphyria
151	GW6471		6: Antagonist binding to PPARα leading to body-weight loss