Prototypical Stressors

Showing 176 to 200 of 855 Prototypical Stressors

ID	Prototypical Stressor Name	Associated Chemical(s): Name, CAS-RN, DTXSID	Associated AOPs

177	atrazine	Atrazine, CAS-RN: 1912-24-9, DTXSID9020112	5 AOPs 168: GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat. 169: GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat. 492: Glutathione conjugation leading to reproductive dysfunction via oxidative stress 561: Aromatase induction leading to estrogen receptor alpha activation via increased estradiol 567: Binding to plastoquinone B site leading to decreased population growth rate via photosystem II inhibition
178	Haloperidol	Haloperidol, CAS-RN: 52-86-8, DTXSID4034150	2 AOPs 170: Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat 555: Inhibition, Ether-a-go-go (ERG) Voltage-Gated Potassium Channel leading to heart failure
179	Reserpine	Reserpine, CAS-RN: 50-55-5, DTXSID7021237	170: Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat
180	2,4-Dinitrophenol	2,4-Dinitrophenol, CAS-RN: 51-28-5, DTXSID0020523	263: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation
181	Ketoprofen	Ketoprofen, CAS-RN: 22071-15-4, DTXSID6020771	177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
182	Phenylbutazone	4-Butyl-1,2-diphenyl-3,5-Pyrazolidinedione, CAS-RN: 50-33-9, DTXSID9021136	177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
183	Amlexanox		None
184	Oxaprozin	Oxaprozin, CAS-RN: 21256-18-8, DTXSID1045118	None
185	Nitazoxanide	Nitazoxanide, CAS-RN: 55981-09-4, DTXSID5033757	None
186	Ketorolac Tromethamine	Ketorolac tromethamine, CAS-RN: 74103-07-4, DTXSID0045597	None
187	Telmisartan	Telmisartan, CAS-RN: 144701-48-4, DTXSID8023636	None
188	Diflunisal	Diflunisal, CAS-RN: 22494-42-4, DTXSID5022932	None
189	Mefenamic acid	Mefenamic acid, CAS-RN: 61-68-7, DTXSID5023243	None
190	flunixin meglumine	Flunixin meglumine, CAS-RN: 42461-84-7, DTXSID1045584	177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
191	Clofibrate	Clofibrate, CAS-RN: 637-07-0, DTXSID3020336	3 AOPs 177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality 37: PPARα activation leading to hepatocellular adenomas and carcinomas in rodents 323: PPARalpha Agonism Leading to Decreased Viable Offspring via Decreased 11-Ketotestosterone
192	Meloxicam	Meloxicam, CAS-RN: 71125-38-7, DTXSID1020803	177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
193	nimesulide	Nimesulide, CAS-RN: 51803-78-2, DTXSID3037250	177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
194	Carprofen	Carprofen, CAS-RN: 53716-49-7, DTXSID1045871	177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
195	Warfarin	Warfarin, CAS-RN: 81-81-2, DTXSID5023742	187: Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage
196	coumachlor	Coumachlor, CAS-RN: 81-82-3, DTXSID8041797	187: Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage
197	coumatetralyl	Coumatetralyl, CAS-RN: 5836-29-3, DTXSID8041799	187: Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage
198	chlorophacinone	Chlorophacinone, CAS-RN: 3691-35-8, DTXSID2032348	187: Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage
199	diphacinone	Diphacinone, CAS-RN: 82-66-6, DTXSID4032378	187: Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage
200	pindone	Pindone, CAS-RN: 83-26-1, DTXSID1025930	187: Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage
201	3-[3-(4'-bromo[1,1'-biphenyl]-4-yl)-3-hydroxy-1-phenylpropyl]-4-hydroxy-2-benzopyrone		187: Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage