Prototypical Stressors

Showing 1 to 25 of 855 Prototypical Stressors

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ID Prototypical Stressor Name Associated Chemical(s): Name, CAS-RN, DTXSID Associated AOPs
858 Carboplatin
  • Carboplatin, CAS-RN: 41575-94-4, DTXSID3046742
472: DNA adduct formation leading to kidney failure
857 Oxaliplatin
  • Oxaliplatin, CAS-RN: 61825-94-3, DTXSID0036760
472: DNA adduct formation leading to kidney failure
856 Chlorotoluron
  • Chlorotoluron, CAS-RN: 15545-48-9, DTXSID8052853
567: Binding to plastoquinone B site leading to decreased population growth rate via photosystem II inhibition
855 Metribuzin
  • Metribuzin, CAS-RN: 21087-64-9, DTXSID6024204
567: Binding to plastoquinone B site leading to decreased population growth rate via photosystem II inhibition
854 ML385
615: Suppression of Keap1 cysteine oxidation leading to liver inflammation
853 Brusatol
615: Suppression of Keap1 cysteine oxidation leading to liver inflammation
852 Tebufenpyrad
  • Tebufenpyrad, CAS-RN: 119168-77-3, DTXSID0034223
3: Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits
851 Pyrimidifen
  • Pyrimidifen, CAS-RN: 105779-78-0, DTXSID9057925
3: Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits
850 Deguelin
  • Deguelin, CAS-RN: 522-17-8, DTXSID10200231
3: Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits
849 Cucurbitacin D
606: Ecdysone receptor antagonism leading to mortality via inhibition of chitin synthase 1
848 Cucurbitacin B
606: Ecdysone receptor antagonism leading to mortality via inhibition of chitin synthase 1
847 Muristerone A
342: Ecdysone receptor hyperactivation leading to mortality via mis-timed activation of nuclear receptor cascade
846 Picoxystrobin
  • Picoxystrobin, CAS-RN: 117428-22-5, DTXSID9047542
587: Inhibition of the mitochondrial complex III of nigro-striatal neurons leads to parkinsonian motor deficits
845 2,2',3,3',4,4',5,5',6,6'-Decabromodiphenyl ether
  • 2,2',3,3',4,4',5,5',6,6'-Decabromodiphenyl ether, CAS-RN: 1163-19-5, DTXSID9020376
None
844 Wilson's disease
590: Increase of intracellular copper leading to cuproptosis via interference with energy metabolism
843 Elesclomol
590: Increase of intracellular copper leading to cuproptosis via interference with energy metabolism
842 CuO nanoparticles
590: Increase of intracellular copper leading to cuproptosis via interference with energy metabolism
841 calcium ionophore
None
840 Redox status
504: SULT1E1 inhibition leading to uterine adenocarcinoma via increased estrogen availability at target organ level
839 Tissue transglutaminase 2 (TG2) enzyme activity
524: Gluten-driven immune activation leading to celiac disease in genetically predisposed individuals
838 Bacterial or viral Infections
524: Gluten-driven immune activation leading to celiac disease in genetically predisposed individuals
837 Gluten
524: Gluten-driven immune activation leading to celiac disease in genetically predisposed individuals
836 7,12-Dimethylbenz(a)anthracene
  • 7,12-Dimethylbenz(a)anthracene, CAS-RN: 57-97-6, DTXSID1020510
563: Aryl hydrocarbon Receptor (AHR) activation causes Premature Ovarian Insufficiency via Bax mediated apoptosis
835 3,3',5,5'-Tetrabromobisphenol A
  • 3,3',5,5'-Tetrabromobisphenol A, CAS-RN: 79-94-7, DTXSID1026081
565: 17β-Hydroxysteroid dehydrogenase 2, inhibition leading to activation, estrogen receptor alpha
834 1,1'-Ethane-1,2-diylbis(pentabromobenzene)
  • 1,1'-Ethane-1,2-diylbis(pentabromobenzene), CAS-RN: 84852-53-9, DTXSID2052732