Prototypical Stressors

Showing 201 to 225 of 855 Prototypical Stressors

ID	Prototypical Stressor Name	Associated Chemical(s): Name, CAS-RN, DTXSID	Associated AOPs

658	Sulfur dioxide	Sulfur dioxide, CAS-RN: 7446-09-5, DTXSID6029672	None
657	Nicotine	Nicotine, CAS-RN: 54-11-5, DTXSID1020930	None
656	Acetaldehyde	Acetaldehyde, CAS-RN: 75-07-0, DTXSID5039224	None
655	Ozone	Ozone, CAS-RN: 10028-15-6, DTXSID0021098	2 AOPs 411: Oxidative stress Leading to Decreased Lung Function 424: Oxidative stress Leading to Decreased Lung Function via CFTR dysfunction
654	Stressor:454 Hydrogen peroxide		None
653	su5402	su5402, CAS-RN: 215543-92-3, DTXSID90415361	None
652	Retinoic acid		None
651	Ethyl Parathion		2 AOPs 405: Organo-Phosphate Chemicals induced inhibition of AChE leading to impaired cognitive function 450: Inhibition of AChE and activation of CYP2E1 leading to sensory axonal peripheral neuropathy and mortality
650	Methyl parathion	Methyl parathion, CAS-RN: 298-00-0, DTXSID1020855	3 AOPs 405: Organo-Phosphate Chemicals induced inhibition of AChE leading to impaired cognitive function 450: Inhibition of AChE and activation of CYP2E1 leading to sensory axonal peripheral neuropathy and mortality 561: Aromatase induction leading to estrogen receptor alpha activation via increased estradiol
649	Paraoxon	Paraoxon, CAS-RN: 311-45-5, DTXSID6024046	2 AOPs 405: Organo-Phosphate Chemicals induced inhibition of AChE leading to impaired cognitive function 450: Inhibition of AChE and activation of CYP2E1 leading to sensory axonal peripheral neuropathy and mortality
648	work stress		403: combined unhealthy lifestyle factors leading to metabolic syndrome
647	physical inactivity		403: combined unhealthy lifestyle factors leading to metabolic syndrome
646	high fat diet		403: combined unhealthy lifestyle factors leading to metabolic syndrome
645	Cigarette smoke	Cigarette smoke, CAS-RN: NOCAS, DTXSID5035038	5 AOPs 403: combined unhealthy lifestyle factors leading to metabolic syndrome 411: Oxidative stress Leading to Decreased Lung Function 424: Oxidative stress Leading to Decreased Lung Function via CFTR dysfunction 425: Oxidative Stress Leading to Decreased Lung Function via Decreased FOXJ1 563: Aryl hydrocarbon Receptor (AHR) activation causes Premature Ovarian Insufficiency via Bax mediated apoptosis
644	Rocilinostat / Ricolinostat		None
643	Staurosporine	Staurosporine, CAS-RN: 62996-74-1, DTXSID6041131	399: Inhibition of Fyna leading to increased mortality via decreased eye size (Microphthalmos)
642	Saracatinib	Saracatinib, CAS-RN: 379231-04-6, DTXSID90191355	399: Inhibition of Fyna leading to increased mortality via decreased eye size (Microphthalmos)
641	Rosmarinic acid		399: Inhibition of Fyna leading to increased mortality via decreased eye size (Microphthalmos)
640	11-Keto-testosterone	11-Ketotestosterone, CAS-RN: 564-35-2, DTXSID8036499	376: Androgen receptor agonism leading to male-biased sex ratio
639	Methyldihydrotestosterone		376: Androgen receptor agonism leading to male-biased sex ratio
638	(-)-Epigallocatechin gallate	(-)-Epigallocatechin gallate, CAS-RN: 989-51-5, DTXSID1029889	2 AOPs 277: Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response 486: Binding to the extracellular protein laminin leading to decreased cognitive function
637	Dimethyl fumarate		277: Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response
636	Dehydroxymethylepoxyquinomicin (DHMEQ)		277: Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response
635	Arsenic	Arsenic, CAS-RN: 7440-38-2, DTXSID4023886	5 AOPs 413: Oxidation and antagonism of reduced glutathione leading to mortality via acute renal failure 499: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via disrupted neurotransmitter release 500: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis 550: Increased LMNA gene mutation leading to heart failure 519: Cardiac ion channels blockade leading to increased incidence of cardiovascular morbidity and mortality
634	nanomaterials		2 AOPs 392: Decreased fibrinolysis and activated bradykinin system leading to hyperinflammation 451: Interaction with lung resident cell membrane components leads to lung cancer