AOPs

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Showing 376 to 400 of 581 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
241 Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis Marvin Martens BY-SA 1468: Activation, Latent Transforming Growth Factor Beta 1 1458: Pulmonary fibrosis
240 DNA Adducts Leading to Liver Hemangiosarcoma Undefined BY-SA None None
239 Oxidative Stress Leading to ILC2-mediated Respiratory Epithelial Remodeling Undefined BY-SA None None
238 Deposition of energy leading to population decline via DNA strand breaks and oocyte apoptosis Knut Erik Tollefsen BY-SA 1686: Deposition of Energy
237 Substance interaction with lung resident cell membrane components leading to atherosclerosis Ulla Vogel BY-SA 1495: Substance interaction with the lung resident cell membrane components 1443: Atherosclerosis Under Development 1.55
236 Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via Ca Channel Inhibition Timothy Allen BY-SA 1431: Serotonin 1A Receptor Agonism 1432: Anti-depressant Activity
235 Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via K Channel Opening Timothy Allen BY-SA 1431: Serotonin 1A Receptor Agonism 1432: Anti-depressant Activity
234 Mu Opioid Receptor Agonism leading to Analgesia via Ca Channel Inhibition Timothy Allen BY-SA 1425: Mu Opioid Receptor Agonism 1428: Analgesia
233 Mu Opioid Receptor Agonism leading to Analgesia via K Channel Opening Timothy Allen BY-SA 1425: Mu Opioid Receptor Agonism 1428: Analgesia
232 NFE2/Nrf2 repression to steatosis Lyle Burgoon Open for adoption 1417: NFE2/Nrf2 repression 459: Increase, Liver steatosis
231 presynaptic neuron 2 repression to epilepsy Lyle Burgoon Open for adoption 1413: Reduced, presynaptic neuron 2 activity 1363: Increased, epilepsy
230 presynaptic neuron 1 activation to epilepsy Lyle Burgoon Open for adoption 1349: Activated, presynaptic neuron 1 1363: Increased, epilepsy
229 Helicobacter pylori to gastric ulcer Lyle Burgoon Open for adoption 1412: Helicobacter pylori infection 1385: Activated, gastric ulcer formation
228 NSAID induced PTGS2 inactivation to gastric ulcer Lyle Burgoon Open for adoption 1408: Reduced, PTGS2 function 1385: Activated, gastric ulcer formation
227 NSAID induced PTGS1 inactivation to gastric ulcer Lyle Burgoon Open for adoption 1402: Reduced, PTGS1 function 1385: Activated, gastric ulcer formation
226 SSRI (Selective serotonin reuptake inhibitor) to hypertension Lyle Burgoon Open for adoption 1317: Decreased, serotonin transporter activity 1343: Increase, hypertension
225 Serotonin transporter activation to agitation Lyle Burgoon Open for adoption None 1345: Increased, agitation
224 Serotonin transporter activation to depression Lyle Burgoon Open for adoption 1397: Increased, serotonin transporter activity 1346: Increased, depression
223 Serotonin transporter activation to seizure Lyle Burgoon Open for adoption 1397: Increased, serotonin transporter activity 1344: Increased, seizure
222 Mental stress to agitation Lyle Burgoon Open for adoption 1396: Increased, glucocorticoid receptor activity 1345: Increased, agitation
221 Mental stress to depression Lyle Burgoon Open for adoption 1396: Increased, glucocorticoid receptor activity 1346: Increased, depression
220 Cyp2E1 Activation Leading to Liver Cancer Francina Webster BY-SA 1391: Activation of Cyp2E1 1395: Liver Cancer WPHA/WNT Endorsed 1.24
219 Inhibition of CYP7B activity leads to decreased reproductive success via decreased sexual behavior Florence Pagé-Larivière BY-SA 1386: CYP7B activity, inhibition 360: Decrease, Population growth rate
218 Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity Florence Pagé-Larivière BY-SA 1386: CYP7B activity, inhibition 360: Decrease, Population growth rate
217 Gastric ulcer formation Lyle Burgoon Open for adoption None