AOP-Wiki

Purpose: A collection of AOPs considered related to Developmental and Reproductive Toxicity
Creation Strategy: A list of candidate DART-related AOPs, identified with the help of AI, as presented in the 24 September 2026 ISTNET-DART meeting in Basel, Switzerland

ID	Title	License	OECD Status
12	Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging	BY-SA	WPHA/WNT Endorsed
13	Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities	BY-SA	WPHA/WNT Endorsed
15	Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations	BY-SA	WPHA/WNT Endorsed
17	Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory	BY-SA	WPHA/WNT Endorsed
23	Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish)	BY-SA	WPHA/WNT Endorsed
25	Aromatase inhibition leading to reproductive dysfunction	BY-SA	WPHA/WNT Endorsed
42	Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals	BY-SA	WPHA/WNT Endorsed
43	Disruption of VEGFR Signaling Leading to Developmental Defects	BY-SA	WPHA/WNT Endorsed
212	Histone deacetylase inhibition leading to testicular atrophy	BY-SA	WPHA/WNT Endorsed
346	Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation	BY-SA	WPHA/WNT Endorsed
442	Binding to voltage gate sodium channels during development leads to cognitive impairment	BY-SA	WPHA/WNT Endorsed

My DART AOPs