AOP-Wiki

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All Key Events

Showing 301 to 325 of 1921 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

2121	decreased, Intellectual Quotient Short Name decreased, IQ	0	Population	Apr 4, 2023	May 29, 2025	2 AOPs 490: Co-activation of IP3R and RyR leads to reduced IQ and increased socio-economic burden through non-cholinergic mechanisms 569: Decreased DNA methylation of FAM50B/PTCHD3 leading to IQ loss of children via PI3K-Akt pathway
2120	Superoxide generation, increased Short Name Superoxide generation, increased	1	Cellular	Apr 3, 2023	Apr 17, 2023	457: Succinate dehydrogenase inhibition leading to increased insulin resistance through reduction in circulating thyroxine
2119	Increase, Insulin resistance Short Name Increase, Insulin resistance	1	Organ	Apr 3, 2023	Feb 11, 2026	7 AOPs 457: Succinate dehydrogenase inhibition leading to increased insulin resistance through reduction in circulating thyroxine 454: PM2.5-related AOP frameworks on liver diseases 493: ERa inactivation alters AT expansion and functions and leads to insulin resistance and metabolically unhealthy obesity 497: ERa inactivation alters mitochondrial functions and insulin signalling in skeletal muscle and leads to insulin resistance and metabolic syndrome 624: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction 625: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress 626: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated endoplasmic reticulum stress
2118	Succinate dehydrogenase, inhibited Short Name SDH, inhibited	3	Molecular	Apr 3, 2023	May 4, 2023	5 AOPs 457: Succinate dehydrogenase inhibition leading to increased insulin resistance through reduction in circulating thyroxine 534: Succinate dehydrogenase (SDH) inhibition leads to oxidative stress 474: Succinate dehydrogenase inactivation leads to cancer by promoting EMT 546: Succinate dehydrogenase inactivation leads to cancer through hypoxic-like mechanisms 588: Inhibition of the mitochondrial complex II of nigro-striatal neurons leads to parkinsonian motor deficits
2117	Increase, goblet cell number Short Name Increase, goblet cell number	1	Cellular	Mar 8, 2023	Mar 8, 2023	148: EGFR Activation Leading to Decreased Lung Function
2116	Decreased, oligodendrocyte differentiation Short Name Oligodendrocyte differentiation	0	Cellular	Feb 22, 2023	Feb 22, 2023	3 AOPs 487: Unknown MIE altering cholesterol metabolism leading to decreased cognition 488: Increased reactive oxygen species production leading to decreased cognitive function 489: Inhibition of voltage-gated sodium channels leading to decreased cognition
2115	Altered, cholesterol metabolism Short Name Cholesterol metabolism	0	Molecular	Feb 22, 2023	Feb 22, 2023	2 AOPs 487: Unknown MIE altering cholesterol metabolism leading to decreased cognition 525: Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory
2114	Disturbed, cortical architecture Short Name Disturbed cortical architecture	0	Organ	Feb 21, 2023	Feb 21, 2023	486: Binding to the extracellular protein laminin leading to decreased cognitive function
2113	Decreased, radial glia cell density Short Name RG density	0	Cellular	Feb 21, 2023	Feb 21, 2023	486: Binding to the extracellular protein laminin leading to decreased cognitive function
2112	Disturbed, radial glia cell alignment and migration Short Name RG alignment and migration	0	Cellular	Feb 21, 2023	Feb 21, 2023	486: Binding to the extracellular protein laminin leading to decreased cognitive function
2111	Decreased, neural progenitor cell adhesion to laminin Short Name NPC adhesion to laminin	0	Cellular	Feb 21, 2023	Feb 21, 2023	486: Binding to the extracellular protein laminin leading to decreased cognitive function
2110	Disrupted binding, laminin-beta1-integrin receptors with laminin Short Name	0	Molecular	Feb 21, 2023	Feb 21, 2023	486: Binding to the extracellular protein laminin leading to decreased cognitive function
2109	Binding, extracellular matrix protein laminin Short Name Binding to laminin	0	Molecular	Feb 21, 2023	Feb 21, 2023	486: Binding to the extracellular protein laminin leading to decreased cognitive function
2108	Altered, white brain matter Short Name Altered, white brain matter	0	Tissue	Feb 21, 2023	Feb 21, 2023	6 AOPs 485: Thyroid hormone antagonism leading to impaired oligodendrocyte maturation during development and subsequent decreased cognition 487: Unknown MIE altering cholesterol metabolism leading to decreased cognition 488: Increased reactive oxygen species production leading to decreased cognitive function 489: Inhibition of voltage-gated sodium channels leading to decreased cognition 525: Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory 610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function
2107	Hypomyelination Short Name Hypomyelination	0	Tissue	Feb 21, 2023	Feb 21, 2023	7 AOPs 485: Thyroid hormone antagonism leading to impaired oligodendrocyte maturation during development and subsequent decreased cognition 487: Unknown MIE altering cholesterol metabolism leading to decreased cognition 488: Increased reactive oxygen species production leading to decreased cognitive function 489: Inhibition of voltage-gated sodium channels leading to decreased cognition 525: Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory 605: Thyroid Peroxidase Inhibition Leading to Reduced, Swimming Performance via Hypomyelination 608: Thyroid Hormone Excess Leading to Reduced, Swimming Performance via Hypomyelination
2106	Impaired, oligodendrocyte maturation Short Name Impaired OL maturation	0	Cellular	Feb 21, 2023	Feb 21, 2023	3 AOPs 485: Thyroid hormone antagonism leading to impaired oligodendrocyte maturation during development and subsequent decreased cognition 605: Thyroid Peroxidase Inhibition Leading to Reduced, Swimming Performance via Hypomyelination 608: Thyroid Hormone Excess Leading to Reduced, Swimming Performance via Hypomyelination
2105	Decreased, myelin basic protein expression in oligodendrocytes Short Name	0	Molecular	Feb 21, 2023	Feb 21, 2023	2 AOPs 485: Thyroid hormone antagonism leading to impaired oligodendrocyte maturation during development and subsequent decreased cognition 610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function
2104	Decreased, thyroid hormone binding to thyroid hormone receptor Short Name Decreased, TH binding to THR	0	Molecular	Feb 21, 2023	Feb 21, 2023	485: Thyroid hormone antagonism leading to impaired oligodendrocyte maturation during development and subsequent decreased cognition
2103	Cellular dysfunction (human placenta trophoblast cells) Short Name	0	Cellular	Feb 7, 2023	Feb 7, 2023	None
2102	Cytotoxicity (human trophoblast cells) Short Name Cytotoxicity (human trophoblast cells)	0	Cellular	Feb 7, 2023	Feb 7, 2023	None
2101	Conformational changes of thyroid receptor Short Name	0	Molecular	Feb 7, 2023	Feb 7, 2023	None
2100	Inhibition of rapid delayed rectifying potassium current Short Name	0	Cellular	Jan 29, 2023	Jan 29, 2023	433: hERG channel blockade leading to sudden cardiac death
2099	hERG channel blockade Short Name hERG channel blockade	0	Molecular	Jan 29, 2023	Jan 29, 2023	433: hERG channel blockade leading to sudden cardiac death
2098	Increase, Abnormal Neural Remodeling Short Name Abnormal Neural Remodeling	3	Tissue	Jan 25, 2023	Jul 26, 2024	483: Deposition of Energy Leading to Learning and Memory Impairment
2097	Increase, Pro-Inflammatory Mediators Short Name Increase, Pro-Inflammatory Mediators	1	Tissue	Jan 25, 2023	Jul 26, 2024	483: Deposition of Energy Leading to Learning and Memory Impairment