AOP-Wiki

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All Key Events

Showing 751 to 775 of 1921 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1634	Increase, Oxidative DNA damage Short Name Increase, Oxidative DNA damage	1	Molecular	May 19, 2019	Oct 8, 2024	6 AOPs 296: Oxidative DNA damage leading to chromosomal aberrations and mutations 299: Deposition of energy leading to population decline via DNA oxidation and follicular atresia 311: Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis 478: Deposition of energy leading to occurrence of cataracts 330: Excessive reactive oxygen species production leading to mortality (4) 602: Excessive reactive oxygen species leading to growth inhibition via oxidative DNA damage
1633	Increase in inflammation Short Name Increase in inflammation	0	Tissue	May 3, 2019	May 3, 2019	3 AOPs 362: Immune mediated hepatitis 447: Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways 493: ERa inactivation alters AT expansion and functions and leads to insulin resistance and metabolically unhealthy obesity
1632	Increase in reactive oxygen and nitrogen species (RONS) Short Name Increase in RONS	0	Molecular	May 3, 2019	May 8, 2019	5 AOPs 293: Increased DNA damage leading to increased risk of breast cancer 294: Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer 432: Deposition of Energy by Ionizing Radiation leading to Acute Myeloid Leukemia 444: Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability 473: Energy deposition from internalized Ra-226 decay lower oxygen binding capacity of hemocyanin
1631	Reduction fo Pigmentation pattern Short Name Reduction fo Pigmentation pattern	0	Individual	May 3, 2019	May 3, 2019	292: Inhibition of tyrosinase leads to decreased population in fish
1630	Reduction of melanosome level Short Name Reduction of melanosome level	0	Tissue	May 3, 2019	May 3, 2019	292: Inhibition of tyrosinase leads to decreased population in fish
1629	Reduction in melanin level Short Name Reduction in melanin level	0	Cellular	May 3, 2019	May 3, 2019	292: Inhibition of tyrosinase leads to decreased population in fish
1628	Reduction of L-Dopaquinone Short Name Reduction of L-Dopaquinone	0	Cellular	May 3, 2019	May 3, 2019	292: Inhibition of tyrosinase leads to decreased population in fish
1627	Inhibition of tyrosinase Short Name tyrosinase	0	Molecular	May 3, 2019	May 3, 2019	292: Inhibition of tyrosinase leads to decreased population in fish
1626	reduction in melanin lead to decrease of pigmentation Short Name melanin, pigmentation	0	Tissue	May 3, 2019	May 3, 2019	None
1625	Reduction of L-Dopaquinone leads to melanin reduction Short Name melanin	0	Cellular	May 3, 2019	May 3, 2019	None
1624	Tyrosinase inhibition leads to L-Dopaquinone reduction Short Name tyrosinase, L-Dopaquinone reduction	0	Molecular	May 3, 2019	May 3, 2019	None
1623	Occurrence, Focal Seizure Short Name Occurrence, Focal Seizure	1	Tissue	Apr 22, 2019	May 20, 2020	281: Acetylcholinesterase Inhibition Leading to Neurodegeneration
1622	Decrease, Transgenerational DNA methylation Short Name	0	Molecular	Apr 22, 2019	Apr 22, 2019	None
1621	Increase, Gene expression Short Name Increase, Gene expression	0	Molecular	Apr 22, 2019	Apr 22, 2019	None
1620	Increase, DNA hypomethylation Short Name Increase, DNA hypomethylation	0	Molecular	Apr 22, 2019	Apr 22, 2019	None
1619	Increase, DNA methyltransferase inhibition Short Name Increase, DNMT inhibition	0	Molecular	Apr 22, 2019	Apr 22, 2019	7 AOPs 336: DNA methyltransferase inhibition leading to population decline (1) 337: DNA methyltransferase inhibition leading to population decline (2) 338: DNA methyltransferase inhibition leading to population decline (3) 339: DNA methyltransferase inhibition leading to population decline (4) 340: DNA methyltransferase inhibition leading to transgenerational effects (1) 341: DNA methyltransferase inhibition leading to transgenerational effects (2) 474: Succinate dehydrogenase inactivation leads to cancer by promoting EMT
1618	Reduction, egg production and spawning Short Name Reduction, egg production and spawning	0	Individual	Apr 18, 2019	Apr 18, 2019	None
1617	Inhibition, 5α-reductase Short Name Inhibition, 5α-reductase	0	Molecular	Apr 18, 2019	Mar 20, 2026	5 AOPs 289: Inhibition of 5α-reductase leading to impaired fecundity in female fish 305: 5α-reductase inhibition leading to short anogenital distance (AGD) in male (mammalian) offspring 120: Inhibition of 5α-reductase leading to Leydig cell tumors (in rat) 571: 5α-reductase inhibition leading to hypospadias in male (mammalian) offspring 576: 5α-reductase inhibition leading to increased nipple retention (NR) in male (rodent) offspring
1616	Malformation, cryptorchidism - maldescended testis Short Name Malformation, cryptorchidism	1	Organ	Apr 10, 2019	Jul 18, 2024	4 AOPs 288: Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals) 372: Androgen receptor antagonism leading to testicular cancer 476: Adverse Outcome Pathways diagram related to PBDEs associated male reproductive toxicity 528: Decreased Insulin-like peptide 3 (INSL3) leads to Malformation, cryptorchidism - maldescended testis
1615	Impaired inguinoscrotal testicular descent phase Short Name Impaired inguinoscrotal phase	1	Organ	Apr 10, 2019	Dec 3, 2024	2 AOPs 288: Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals) 528: Decreased Insulin-like peptide 3 (INSL3) leads to Malformation, cryptorchidism - maldescended testis
1614	Decrease, androgen receptor activation Short Name Decrease, AR activation	1	Tissue	Apr 10, 2019	Mar 20, 2026	13 AOPs 288: Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals) 305: 5α-reductase inhibition leading to short anogenital distance (AGD) in male (mammalian) offspring 306: Androgen receptor (AR) antagonism leading to short anogenital distance (AGD) in male (mammalian) offspring 307: Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring 344: Androgen receptor (AR) antagonism leading to nipple retention (NR) in male (mammalian) offspring 372: Androgen receptor antagonism leading to testicular cancer 477: Androgen receptor (AR) antagonism leading to hypospadias in male (mammalian) offspring 345: Androgen receptor (AR) antagonism leading to decreased fertility in females 111: Decrease in androgen receptor activity leading to Leydig cell tumors (in rat) 570: Decreased testosterone synthesis leading to hypospadias in male (mammalian) offspring 571: 5α-reductase inhibition leading to hypospadias in male (mammalian) offspring 575: Decreased testosterone synthesis leading to increased nipple retention (NR) in male (rodent) offspring 576: 5α-reductase inhibition leading to increased nipple retention (NR) in male (rodent) offspring
1613	Decrease, dihydrotestosterone (DHT) levels Short Name Decrease, DHT level	1	Tissue	Apr 10, 2019	Mar 20, 2026	6 AOPs 288: Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals) 289: Inhibition of 5α-reductase leading to impaired fecundity in female fish 305: 5α-reductase inhibition leading to short anogenital distance (AGD) in male (mammalian) offspring 527: Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) leads to Hypospadias, increased 571: 5α-reductase inhibition leading to hypospadias in male (mammalian) offspring 576: 5α-reductase inhibition leading to increased nipple retention (NR) in male (rodent) offspring
1611	Reduction, androstenedione Short Name Reduction, androstenedione	0	Tissue	Apr 10, 2019	Apr 9, 2025	288: Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals)
1610	Reduction, dehydroepiandrosterone Short Name Reduction, DHEA	0	Tissue	Apr 10, 2019	Apr 8, 2025	288: Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals)
1609	Inhibition, Cytochrome P450 enzyme (CYP17A1) activity Short Name Inhibition of Cyp17A1 activity	0	Molecular	Apr 10, 2019	Apr 8, 2025	288: Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals)