AOP-Wiki

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All Key Events

Showing 1051 to 1075 of 1921 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1321	Increased, intracellular sodium (Na+) Short Name Increased, intracellular sodium (Na+)	0	Molecular	Apr 13, 2017	Apr 13, 2017	4 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 215: Molecular events lead to epilepsy 230: presynaptic neuron 1 activation to epilepsy 556: Decreased Na/K ATPase activity leading to heart failure
1320	Increased, extracellular serotonin Short Name Increased, extracellular serotonin	2	Molecular	Apr 13, 2017	Feb 13, 2025	8 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 221: Mental stress to depression 222: Mental stress to agitation 223: Serotonin transporter activation to seizure 224: Serotonin transporter activation to depression 225: Serotonin transporter activation to agitation 226: SSRI (Selective serotonin reuptake inhibitor) to hypertension 568: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) leads to Inhibition, Feeding
1319	Decreased, extracellular chloride (Cl-) Short Name Decreased, extracellular chloride (Cl-)	0	Molecular	Apr 13, 2017	Apr 13, 2017	214: Network of SSRIs (selective serotonin reuptake inhibitors)
1318	Decreased, extracellular sodium (Na+) Short Name Decreased, extracellular Na+	0	Molecular	Apr 13, 2017	Apr 13, 2017	214: Network of SSRIs (selective serotonin reuptake inhibitors)
1317	Decreased, serotonin transporter activity Short Name	0	Molecular	Apr 13, 2017	May 31, 2017	4 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 221: Mental stress to depression 222: Mental stress to agitation 226: SSRI (Selective serotonin reuptake inhibitor) to hypertension
1316	Inhibit, serotonin transporter activity Short Name Inhibit, serotonin transporter activity	0	Molecular	Apr 13, 2017	Apr 13, 2017	214: Network of SSRIs (selective serotonin reuptake inhibitors)
1315	Increase, Selective Serotonin Reuptake Inhibitors (SSRIs) Short Name Increase, SSRIs	0	Molecular	Apr 13, 2017	Apr 13, 2017	None
1314	Activation, LRH-1 Short Name Activation, LRH-1	0	Molecular	Apr 13, 2017	Apr 13, 2017	None
1313	Decrease, cytosolic fatty acid Short Name Decrease, cytosolic fatty acid	0	Molecular	Apr 13, 2017	Apr 13, 2017	None
1312	Increase, Fatty acid beta-oxidation Short Name Increase, Fatty acid β-oxidation	0	Cellular	Apr 13, 2017	Dec 4, 2020	2 AOPs 612: Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via reduced adenosine triphosphate 613: Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via increased reactive oxygen species production
1310	Activation, PI3K Short Name Activation, PI3K	0	Molecular	Apr 13, 2017	Apr 13, 2017	401: G protein-coupled estrogen receptor 1 (GPER) signal pathway in the lipid metabolism disrupting effects
1309	Activation, aPKC Short Name Activation, aPKC	0	Molecular	Apr 13, 2017	Apr 13, 2017	None
1308	Inhibition, LRH-1 Short Name Inhibition, LRH-1	0	Molecular	Apr 12, 2017	Apr 12, 2017	None
1307	Inhibition, LXR Short Name Inhibition, LXR	0	Molecular	Apr 12, 2017	Apr 12, 2017	None
1306	Increase, De novo lipogenesis Short Name Increase, De novo lipogenesis	0	Cellular	Apr 12, 2017	Feb 10, 2026	3 AOPs 627: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated mitochondrial dysfunction 628: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated oxidative stress 629: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated endoplasmic reticulum stress
1305	Increase, cytosolic fatty acid Short Name Increase, cytosolic fatty acid	0	Cellular	Apr 12, 2017	Nov 27, 2017	213: Inhibition of fatty acid beta oxidation leading to nonalcoholic steatohepatitis (NASH)
1304	Activation, FXR Short Name Activation, FXR	0	Molecular	Apr 12, 2017	Apr 12, 2017	None
1303	Activation, HSD17B4 Short Name Activation, HSD17B4	0	Molecular	Apr 12, 2017	Apr 12, 2017	None
1302	Activation, L-FABP Short Name Activation, L-FABP	0	Molecular	Apr 12, 2017	Apr 13, 2017	None
1301	Activation, SREBP-1 Short Name Activation, SREBP-1	0	Molecular	Apr 12, 2017	Apr 12, 2017	None
1300	Activation, mTORC1 Short Name Activation, mTORC1	0	Molecular	Apr 12, 2017	Apr 12, 2017	401: G protein-coupled estrogen receptor 1 (GPER) signal pathway in the lipid metabolism disrupting effects
1299	Activation, AKT Short Name Activation, AKT	0	Molecular	Apr 12, 2017	Apr 12, 2017	401: G protein-coupled estrogen receptor 1 (GPER) signal pathway in the lipid metabolism disrupting effects
1298	Activation, mTORC2 Short Name Activation, mTORC2	0	Molecular	Apr 12, 2017	Apr 12, 2017	None
1297	Activation, insulin receptor Short Name Activation, insulin receptor	0	Molecular	Apr 12, 2017	Apr 12, 2017	None
1296	Increase, insulin Short Name Increase, insulin	0	Molecular	Apr 12, 2017	Apr 12, 2017	None