AOP-Wiki

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All Key Events

Showing 1076 to 1100 of 1921 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1295	Defect of Embryogenesis Short Name Defect of Embryogenesis	1	Tissue	Feb 15, 2017	Sep 16, 2017	210: Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building
1294	Inhibition, Wnt pathway Short Name Inhibition, Wnt pathway	1	Cellular	Feb 15, 2017	Sep 16, 2017	210: Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building
1293	Activation, FOXO Short Name Activation, FOXO	1	Cellular	Feb 15, 2017	Sep 16, 2017	2 AOPs 210: Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building 591: DBDPE-induced DNA damage increase in liver leading to Non-alcoholic fatty liver disease via liver steatosis and inhibition of regeneration
1292	Activation, JNK Short Name Activation, JNK	1	Cellular	Feb 15, 2017	Sep 16, 2017	2 AOPs 210: Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building 347: Toll-like receptor 4 activation and peroxisome proliferator-activated receptor gamma inactivation leading to pulmonary fibrosis
1291	Hepatotoxicity Short Name Hepatotoxicity	0	Cellular	Feb 15, 2017	Feb 15, 2017	209: Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP
1290	Glutathione homeostasis Short Name Glutathione homeostasis	1	Cellular	Feb 15, 2017	Sep 16, 2017	209: Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP
1289	Perturbation of cholesterol Short Name Perturbation of cholesterol	1	Cellular	Feb 15, 2017	Sep 16, 2017	209: Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP
1288	Activation, 3-hydroxy-3-methylglutaryl-CoA reductase gene Short Name	1	Cellular	Feb 15, 2017	Sep 16, 2017	2 AOPs 209: Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP 594: Micro plastic effect on reproduction
1287	Glutathione synthesis Short Name Glutathione synthesis	1	Cellular	Feb 15, 2017	Sep 16, 2017	209: Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP
1286	Down Regulation, GSS and GSTs gene Short Name Down Regulation, GSS and GSTs gene	2	Cellular	Feb 15, 2017	Sep 16, 2017	209: Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP
1285	Up Regulation, Unsaturated fatty acid Short Name Up Regulation, Unsaturated fatty acid	1	Cellular	Feb 15, 2017	Sep 16, 2017	209: Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP
1284	Up Regulation, SREBF2 Short Name Up Regulation, SREBF2	1	Cellular	Feb 15, 2017	Sep 16, 2017	2 AOPs 209: Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP 401: G protein-coupled estrogen receptor 1 (GPER) signal pathway in the lipid metabolism disrupting effects
1283	Activation, TGF-beta pathway Short Name Activation, TGF-beta pathway	1	Cellular	Feb 15, 2017	Sep 16, 2017	3 AOPs 208: Janus kinase (JAK)/Signal transducer and activator of transcription (STAT) and Transforming growth factor (TGF)-beta pathways activation leading to reproductive failure 347: Toll-like receptor 4 activation and peroxisome proliferator-activated receptor gamma inactivation leading to pulmonary fibrosis 622: Calcineurin inhibitor induced nephrotoxicity leading to kidney failure
1282	Activation, JAK/STAT pathway Short Name Activation, JAK/STAT pathway	2	Cellular	Feb 15, 2017	Sep 16, 2017	208: Janus kinase (JAK)/Signal transducer and activator of transcription (STAT) and Transforming growth factor (TGF)-beta pathways activation leading to reproductive failure
1281	Increased, DNA Damage-Repair Short Name Increased, DNA Damage-Repair	1	Cellular	Feb 15, 2017	Sep 16, 2017	2 AOPs 207: NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans 592: DBDPE-induced DNA strand breaks and LDH activity inhibition leading to population growth rate decline via energy metabolism disrupt and apoptosis
1280	Activation, HIF-1 Short Name Activation, HIF-1	1	Cellular	Feb 15, 2017	Sep 16, 2017	207: NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans
1279	Increase, Oxidative Stress / Activation, PMK-1 P38 MAPK Short Name	2	Cellular	Feb 15, 2017	Sep 16, 2017	207: NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans
1277	Reproductive failure Short Name Reproductive failure	1	Individual	Feb 15, 2017	Feb 15, 2017	4 AOPs 207: NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans 208: Janus kinase (JAK)/Signal transducer and activator of transcription (STAT) and Transforming growth factor (TGF)-beta pathways activation leading to reproductive failure 210: Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building 594: Micro plastic effect on reproduction
1276	Lung fibrosis Short Name Lung fibrosis	0	Organ	Feb 15, 2017	Dec 26, 2017	5 AOPs 206: Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis 319: Binding to ACE2 leading to lung fibrosis 382: Angiotensin II type 1 receptor (AT1R) agonism leading to lung fibrosis 414: Aryl hydrocarbon receptor activation leading to lung fibrosis through TGF-β dependent fibrosis toxicity pathway 415: Aryl hydrocarbon receptor activation leading to lung fibrosis through IL-6 toxicity pathway
1275	Collagen Deposition Short Name Collagen Deposition	0	Tissue	Feb 15, 2017	Feb 15, 2017	206: Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis
1274	Production of α-smooth muscle actin Short Name Production of α-smooth muscle actin	0	Cellular	Feb 15, 2017	Feb 15, 2017	None
1273	Expression of Collagen Short Name Expression of Collagen	0	Cellular	Feb 15, 2017	Feb 15, 2017	None
1272	Increase, Myofibroblast expansion Short Name Increase, Myofibroblast expansion	0	Cellular	Feb 15, 2017	Feb 10, 2026	None
1271	Increase, Transforming growth factor-beta signaling Short Name Activation of TGF-β signaling	0	Molecular	Feb 15, 2017	Feb 11, 2026	7 AOPs 206: Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis 624: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction 625: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress 626: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated endoplasmic reticulum stress 627: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated mitochondrial dysfunction 628: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated oxidative stress 629: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated endoplasmic reticulum stress
1270	Inactivation of PPARγ Short Name Inactivation of PPARγ	0	Molecular	Feb 15, 2017	Dec 26, 2017	2 AOPs 206: Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis 347: Toll-like receptor 4 activation and peroxisome proliferator-activated receptor gamma inactivation leading to pulmonary fibrosis