AOP-Wiki

API

All Key Events

Showing 1251 to 1275 of 1921 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1114	Unknown, MIE Short Name Unknown, MIE	0	Molecular	Nov 29, 2016	Dec 3, 2016	2 AOPs 186: unknown MIE leading to renal failure and mortality 487: Unknown MIE altering cholesterol metabolism leading to decreased cognition
1113	Unknown, Short Name Unknown,	0		Nov 29, 2016	Nov 29, 2016	None
1111	weaj, Short Name weaj,	0		Nov 29, 2016	Nov 29, 2016	None
1110	Increased, Energetic demands and therefore metabolic stress Short Name	2	Individual	Nov 29, 2016	Dec 3, 2016	183: Nosema infection increases energetic demands leading to colony loss/failure
1109	Increased, Deformed Wing Virus levels Short Name Increased, Deformed Wing Virus levels	1	Individual	Nov 29, 2016	Dec 3, 2016	179: Varroa mite infestation increases virus levels leading to colony loss/failure
1108	Abnormal, Role change within caste Short Name Abnormal, Role change within caste	1	Population	Nov 29, 2016	Jun 7, 2018	3 AOPs 89: Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure 87: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure 184: Nosema infection causes abnormal role change that leads to colony loss/failure
1107	Weakened, Colony Short Name Weakened, Colony	1	Population	Nov 29, 2016	Jun 7, 2018	13 AOPs 77: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1 87: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure 88: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste 89: Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure 79: Nicotinic acetylcholine receptor activation contributes to impaired hive thermoregulation and leads to colony loss/failure 178: Nicotinic acetylcholine receptor activation contributes to mitochondrial dysfunction and leads to colony loss/failure 179: Varroa mite infestation increases virus levels leading to colony loss/failure 180: Varroa mite infestation contributes to abnormal foraging leading to colony loss/failure 181: Weather event contributes to colony loss/failure 182: Weather event contributes abnormal foraging leading to colony loss/failure 183: Nosema infection increases energetic demands leading to colony loss/failure 184: Nosema infection causes abnormal role change that leads to colony loss/failure 185: Queen egg-laying decrease leads to colony loss/failure
1106	Occurrence, cardiac arrhythmia Short Name Occurrence, cardiac arrhythmia	1	Organ	Nov 29, 2016	Sep 16, 2017	8 AOPs 177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality 138: Organic anion transporter (OAT1) inhibition leading to renal failure and mortality 186: unknown MIE leading to renal failure and mortality 551: Increased Muscarinic M2 Receptor leading to Arrhythmia 554: β-adrenergic receptor agonists leading to arrhythmias. 559: Inhibition of acetylcholinesterase (AChE) leading to arrhythmias 560: Inhibition of Funny current (If) leading to Arrhythmias 562: HCN Channel Inhibition leading to Arrhythmias
1105	Occurrence, renal ischemia Short Name Occurrence, renal ischemia	1	Tissue	Nov 29, 2016	Dec 3, 2016	177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
1104	Decreased, Prostaglandin F2alpha concentration, plasma Short Name	1	Tissue	Nov 29, 2016	Sep 16, 2017	177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
1103	Inhibition, Cyclooxygenase 1 activity Short Name Inhibition, Cyclooxygenase 1 activity	1	Molecular	Nov 29, 2016	Dec 3, 2016	177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
1102	Occurrence, tophi (urate) deposition Short Name Occurrence, tophi (urate) deposition	1	Tissue	Nov 29, 2016	Dec 3, 2016	2 AOPs 138: Organic anion transporter (OAT1) inhibition leading to renal failure and mortality 177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
1101	Altered, Amphibian metamorphosis Short Name Altered, Amphibian metamorphosis	2	Organ	Nov 29, 2016	Sep 2, 2020	11 AOPs 175: Thyroperoxidase inhibition leading to altered amphibian metamorphosis 176: Sodium Iodide Symporter (NIS) Inhibition leading to altered amphibian metamorphosis 188: Iodotyrosine deiodinase (IYD) inhibition leading to altered amphibian metamorphosis 189: Type I iodothyronine deiodinase (DIO1) inhibition leading to altered amphibian metamorphosis 190: Type II iodothyronine deiodinase (DIO2) inhibition leading to altered amphibian metamorphosis 191: Type III iodotyrosine deiodinase (DIO3) inhibition leading to altered amphibian metamorphosis 192: Pendrin inhibition leading to altered amphibian metamorphosis 193: Dual oxidase (DUOX) inhibition leading to altered amphibian metamorphosis 194: Hepatic nuclear receptor activation leading to altered amphibian metamorphosis 366: Competitive binding to thyroid hormone carrier protein transthyretin (TTR) leading to altered amphibian metamorphosis 367: Competitive binding to thyroid hormone carrier protein thyroid binding globulin (TBG) leading to altered amphibian metamorphosis
1100	Occurrence, cardiac arrthymia Short Name Occurrence, cardiac arrthymia	0		Nov 29, 2016	Nov 29, 2016	None
1098	Increased, blood potassium concentration Short Name	1	Tissue	Nov 29, 2016	Sep 16, 2017	4 AOPs 138: Organic anion transporter (OAT1) inhibition leading to renal failure and mortality 177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality 186: unknown MIE leading to renal failure and mortality 551: Increased Muscarinic M2 Receptor leading to Arrhythmia
1097	Occurrence, renal proximal tubular necrosis Short Name	1	Tissue	Nov 29, 2016	Sep 16, 2017	5 AOPs 138: Organic anion transporter (OAT1) inhibition leading to renal failure and mortality 177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality 186: unknown MIE leading to renal failure and mortality 447: Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways 472: DNA adduct formation leading to kidney failure
1096	Increased, blood uric acid concentration Short Name	1	Tissue	Nov 29, 2016	Sep 16, 2017	2 AOPs 138: Organic anion transporter (OAT1) inhibition leading to renal failure and mortality 177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
1095	hyperuricemia, Short Name hyperuricemia,	0		Nov 29, 2016	Nov 29, 2016	None
1094	, hyperuricemia Short Name , hyperuricemia	0		Nov 29, 2016	Nov 29, 2016	None
1093	Decreased, Thyroxine (T4) in tissues Short Name Decreased, Thyroxine (T4) in tissues	2	Tissue	Nov 29, 2016	Sep 3, 2020	None
1092	Pulmonary Fibrosis, Short Name Pulmonary Fibrosis,	0		Nov 29, 2016	Nov 29, 2016	None
1091	Physical and/or chemical interaction with cellular components, Short Name	0		Nov 29, 2016	Nov 29, 2016	None
1090	Increased, mesotheliomas Short Name Increased, mesotheliomas	1	Tissue	Nov 29, 2016	Dec 3, 2016	2 AOPs 171: Chronic cytotoxicity of the serous membrane leading to pleural/peritoneal mesotheliomas in the rat. 409: Frustrated phagocytosis leads to malignant mesothelioma
1089	Increased, Cell Proliferation (mesothelium) Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	171: Chronic cytotoxicity of the serous membrane leading to pleural/peritoneal mesotheliomas in the rat.
1087	Increased, inflammation Short Name Increased, inflammation	1	Cellular	Nov 29, 2016	Dec 3, 2016	171: Chronic cytotoxicity of the serous membrane leading to pleural/peritoneal mesotheliomas in the rat.