AOP-Wiki

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All Key Events

Showing 1351 to 1375 of 1921 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1008	Reduced, Hearing Short Name Reduced, Hearing	1	Organ	Nov 29, 2016	Feb 18, 2019	410: GSK3beta inactivation leading to increased mortality via defects in developing inner ear
1007	Reduced, Anterior swim bladder inflation Short Name	1	Organ	Nov 29, 2016	Oct 7, 2022	3 AOPs 156: Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation 158: Deiodinase 1 inhibition leading to increased mortality via reduced anterior swim bladder inflation 159: Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation
1005	Reduced, Swimming performance Short Name Reduced, Swimming performance	1	Individual	Nov 29, 2016	Sep 8, 2021	10 AOPs 155: Deiodinase 2 inhibition leading to increased mortality via reduced posterior swim bladder inflation 156: Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation 157: Deiodinase 1 inhibition leading to increased mortality via reduced posterior swim bladder inflation 158: Deiodinase 1 inhibition leading to increased mortality via reduced anterior swim bladder inflation 159: Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation 242: Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity 334: Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration 605: Thyroid Peroxidase Inhibition Leading to Reduced, Swimming Performance via Hypomyelination 608: Thyroid Hormone Excess Leading to Reduced, Swimming Performance via Hypomyelination 611: Behavioral abnormalities due to increased expression of dopamine transporter and receptor-related genes
1004	Reduced, Posterior swim bladder inflation Short Name	1	Organ	Nov 29, 2016	Oct 7, 2022	2 AOPs 155: Deiodinase 2 inhibition leading to increased mortality via reduced posterior swim bladder inflation 157: Deiodinase 1 inhibition leading to increased mortality via reduced posterior swim bladder inflation
1003	Decreased, Triiodothyronine (T3) Short Name Decreased, Triiodothyronine (T3)	1	Tissue	Nov 29, 2016	Oct 7, 2022	10 AOPs 155: Deiodinase 2 inhibition leading to increased mortality via reduced posterior swim bladder inflation 156: Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation 157: Deiodinase 1 inhibition leading to increased mortality via reduced posterior swim bladder inflation 158: Deiodinase 1 inhibition leading to increased mortality via reduced anterior swim bladder inflation 189: Type I iodothyronine deiodinase (DIO1) inhibition leading to altered amphibian metamorphosis 159: Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation 363: Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure 364: Thyroperoxidase inhibition leading to altered visual function via decreased eye size 365: Thyroperoxidase inhibition leading to altered visual function via altered photoreceptor patterning 605: Thyroid Peroxidase Inhibition Leading to Reduced, Swimming Performance via Hypomyelination
1002	Inhibition, Deiodinase 2 Short Name Inhibition, Deiodinase 2	1	Molecular	Nov 29, 2016	Nov 19, 2025	4 AOPs 155: Deiodinase 2 inhibition leading to increased mortality via reduced posterior swim bladder inflation 156: Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation 190: Type II iodothyronine deiodinase (DIO2) inhibition leading to altered amphibian metamorphosis 610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function
1001	Increased, Developmental Defects Short Name Increased, Developmental Defects	1	Molecular	Nov 29, 2016	Aug 31, 2023	43: Disruption of VEGFR Signaling Leading to Developmental Defects
1000	stabilization, PPAR alpha co-repressor Short Name stabilization, PPAR alpha co-repressor	2	Molecular	Nov 29, 2016	Apr 30, 2019	6: Antagonist binding to PPARα leading to body-weight loss
999	stabilization, co-repressor Short Name stabilization, co-repressor	0		Nov 29, 2016	Nov 29, 2016	None
998	Binding of antagonist, PPAR alpha Short Name Binding of antagonist, PPAR alpha	1	Molecular	Nov 29, 2016	Sep 16, 2017	6: Antagonist binding to PPARα leading to body-weight loss
997	Decreased, Population size Short Name Decreased, Population size	0	Population	Nov 29, 2016	Dec 3, 2016	396: Deposition of ionizing energy leads to population decline via impaired meiosis
996	Decrease, Digestion of old cuticle Short Name Decrease, Digestion of old cuticle	0	Organ	Nov 29, 2016	Oct 21, 2020	2 AOPs 358: Chitinase inhibition leading to mortality 359: Chitobiase inhibition leading to mortality
994	Decreased, Synthesis of molting fluid proteases Short Name	0	Tissue	Nov 29, 2016	Dec 3, 2016	None
993	Decrease, Abdominal muscle contraction Short Name Decrease, Abdominal muscle contraction	1	Tissue	Nov 29, 2016	May 24, 2018	3 AOPs 4: Ecdysone receptor agonism leading to mortality via suppression of Ftz-f1 342: Ecdysone receptor hyperactivation leading to mortality via mis-timed activation of nuclear receptor cascade 343: Ecdysone receptor antagonism leading to mortality via mis-timed ecdysone receptor-responsive nuclear receptor cascade
992	Decreased, Population 2 Short Name Decreased, Population 2	0		Nov 29, 2016	Nov 29, 2016	None
990	Increase, Incomplete ecdysis Short Name Increase, Incomplete ecdysis	1	Individual	Nov 29, 2016	May 24, 2018	5 AOPs 466: Doda decarboxylase leading to mortality 467: Knickkopf leading to mortality 4: Ecdysone receptor agonism leading to mortality via suppression of Ftz-f1 342: Ecdysone receptor hyperactivation leading to mortality via mis-timed activation of nuclear receptor cascade 343: Ecdysone receptor antagonism leading to mortality via mis-timed ecdysone receptor-responsive nuclear receptor cascade
989	Decreased, synthesis and secretion of molting fluid proteases Short Name	0		Nov 29, 2016	Nov 29, 2016	None
988	Decrease, Circulating ecdysis triggering hormone Short Name Decrease, Circulating ETH	1	Tissue	Nov 29, 2016	May 24, 2018	3 AOPs 4: Ecdysone receptor agonism leading to mortality via suppression of Ftz-f1 342: Ecdysone receptor hyperactivation leading to mortality via mis-timed activation of nuclear receptor cascade 343: Ecdysone receptor antagonism leading to mortality via mis-timed ecdysone receptor-responsive nuclear receptor cascade
987	Metaplasia of goblet cells Short Name Metaplasia of goblet cells	0	Molecular	Nov 29, 2016	Oct 5, 2020	None
986	Impairment of TDAR Short Name Impairment of TDAR	0	Individual	Nov 29, 2016	Mar 2, 2023	None
985	Relief, Relief of atopic dermatitis Short Name Relief, Relief of atopic dermatitis	0	Individual	Nov 29, 2016	Dec 3, 2016	None
984	Impairment, T-cell dependent antibody response Short Name	1	Individual	Nov 29, 2016	Feb 19, 2023	2 AOPs 154: Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response 277: Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response
983	Suppression, Suppression of T-cell dependent antibody response (TDAR) Short Name	0	Cellular	Nov 29, 2016	Dec 3, 2016	None
982	Suppression, Suppression in mixed lymphocyte reaction (MLR) Short Name	0	Cellular	Nov 29, 2016	Dec 3, 2016	None
981	Reduction, NFAT/AP-1 complex formation Short Name Reduction, NFAT/AP-1 complex formation	2	Cellular	Nov 29, 2016	Jun 27, 2021	154: Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response