AOP-Wiki

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All Key Events

Showing 1476 to 1500 of 1921 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

818	Occurrence, Cytoplasmic vacuolization (Renal tubule) Short Name	1	Organ	Nov 29, 2016	Sep 16, 2017	128: Kidney dysfunction by decreased thyroid hormone
814	Occurrence, Kidney toxicity Short Name Occurrence, Kidney toxicity	1	Organ	Nov 29, 2016	Mar 4, 2022	7 AOPs 128: Kidney dysfunction by decreased thyroid hormone 256: Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity 257: Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity 258: Renal protein alkylation leading to kidney toxicity 377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS) 437: Inhibition of mitochondrial electron transport chain (ETC) complexes leading to kidney toxicity 447: Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways
813	Increased, Serum creatinine Short Name Increased, Serum creatinine	2	Organ	Nov 29, 2016	Sep 16, 2017	128: Kidney dysfunction by decreased thyroid hormone
809	malformed, Male reproductive tract Short Name malformed, Male reproductive tract	1	Individual	Nov 29, 2016	Sep 16, 2017	124: HMG-CoA reductase inhibition leading to decreased fertility
807	Decreased, cholesterol Short Name Decreased, cholesterol	3	Tissue	Nov 29, 2016	May 24, 2022	2 AOPs 124: HMG-CoA reductase inhibition leading to decreased fertility 323: PPARalpha Agonism Leading to Decreased Viable Offspring via Decreased 11-Ketotestosterone
805	Decreased, mevalonate Short Name Decreased, mevalonate	1	Cellular	Nov 29, 2016	Dec 3, 2016	124: HMG-CoA reductase inhibition leading to decreased fertility
804	Inhibition, HMG-CoA reductase Short Name Inhibition, HMG-CoA reductase	1	Cellular	Nov 29, 2016	Dec 3, 2016	124: HMG-CoA reductase inhibition leading to decreased fertility
802	Increased, HIF-1 alpha transcription Short Name Increased, HIF-1 alpha transcription	1	Cellular	Nov 29, 2016	Dec 3, 2016	123: Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription
801	modulation, Unknown Short Name modulation, Unknown	1	Molecular	Nov 29, 2016	Dec 3, 2016	123: Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription
800	Decreased, Aromatase (Cyp19a1) mRNA Short Name Decreased, Aromatase (Cyp19a1) mRNA	2	Cellular	Nov 29, 2016	Sep 16, 2017	2 AOPs 122: Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation 123: Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription
799	Increased, HIF-1 heterodimer Short Name Increased, HIF-1 heterodimer	2	Cellular	Nov 29, 2016	Dec 3, 2016	2 AOPs 122: Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation 123: Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription
798	Inhibition, Prolyl hydroxylases Short Name Inhibition, Prolyl hydroxylases	1	Cellular	Nov 29, 2016	Dec 3, 2016	2 AOPs 122: Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation 546: Succinate dehydrogenase inactivation leads to cancer through hypoxic-like mechanisms
797	Increase, Adenomas/carcinomas (urothelial) Short Name	2	Tissue	Nov 29, 2016	Sep 16, 2017	121: Urinary bladder calculi leading to urothelial papillomas and carcinomas (in mouse and rat)
796	Increase, Hyperplasia (urothelial) Short Name Increase, Hyperplasia (urothelial)	1	Cellular	Nov 29, 2016	Sep 16, 2017	2 AOPs 121: Urinary bladder calculi leading to urothelial papillomas and carcinomas (in mouse and rat) 335: AOP for urothelial carcinogenesis due to chemical cytotoxicity by mitochondrial impairment
795	Increase, Regenerative cell proliferation (urothelial cells) Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	2 AOPs 121: Urinary bladder calculi leading to urothelial papillomas and carcinomas (in mouse and rat) 335: AOP for urothelial carcinogenesis due to chemical cytotoxicity by mitochondrial impairment
794	Increase, Cytotoxicity (urothelial cells) Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	121: Urinary bladder calculi leading to urothelial papillomas and carcinomas (in mouse and rat)
793	Increase, Urinary bladder calculi Short Name Increase, Urinary bladder calculi	1	Organ	Nov 29, 2016	Oct 26, 2017	121: Urinary bladder calculi leading to urothelial papillomas and carcinomas (in mouse and rat)
791	Increased, Leutinizing hormone (LH) Short Name Increased, Leutinizing hormone (LH)	1	Tissue	Nov 29, 2016	Sep 16, 2017	120: Inhibition of 5α-reductase leading to Leydig cell tumors (in rat)
788	Decrease, Incorporation of active iodide into iodotyrosines Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	None
787	Increase, Regenerative cell proliferation (hepatocytes) Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	118: Chronic cytotoxicity leading to hepatocellular adenomas and carcinomas (in mouse and rat)
786	Increase, Cytotoxicity (hepatocytes) Short Name Increase, Cytotoxicity (hepatocytes)	1	Cellular	Nov 29, 2016	Sep 16, 2017	118: Chronic cytotoxicity leading to hepatocellular adenomas and carcinomas (in mouse and rat)
784	Increase, Hyperplasia (tubular epithelial cells) Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	116: Cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat)
783	Increase, Cytotoxicity (tubular epithelial cells) Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	116: Cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat)
782	Increase, Hyperplasia (forestomach epithelial cells) Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	115: Epithelial cytotoxicity leading to forestomach tumors (in mouse and rat)
781	Increase, Regenerative cell proliferation (forestomach epithelial cells) Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	115: Epithelial cytotoxicity leading to forestomach tumors (in mouse and rat)