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All Key Events

Showing 1526 to 1550 of 1921 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

754	Increased, Luteinizing hormone (LH) Short Name Increased, Luteinizing hormone (LH)	1	Tissue	Nov 29, 2016	Sep 16, 2017	111: Decrease in androgen receptor activity leading to Leydig cell tumors (in rat)
753	Increase, Thyroid-stimulating hormone (TSH) Short Name	2	Tissue	Nov 29, 2016	Sep 16, 2017	None
752	Altered, Meiotic chromosome dynamics Short Name Altered, Meiotic chromosome dynamics	1	Cellular	Nov 29, 2016	May 27, 2019	3 AOPs 106: Chemical binding to tubulin in oocytes leading to aneuploid offspring 396: Deposition of ionizing energy leads to population decline via impaired meiosis 435: Deposition of ionising energy leads to population decline via pollen abnormal
749	Decreased, Progesterone from corpus luteum Short Name	1	Tissue	Nov 29, 2016	Sep 16, 2017	112: Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat)
748	Increased, Estrogen receptor (ER) activity Short Name	1	Molecular	Nov 29, 2016	Dec 3, 2016	465: Alcohol dehydrogenase leading to reproductive dysfunction
747	Decreased, Prolactin Short Name Decreased, Prolactin	1	Tissue	Nov 29, 2016	Sep 16, 2017	112: Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat)
746	Increase, Dopaminergic activity Short Name Increase, Dopaminergic activity	1	Cellular	Nov 29, 2016	Sep 16, 2017	2 AOPs 112: Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat) 611: Behavioral abnormalities due to increased expression of dopamine transporter and receptor-related genes
745	Increase, Leydig cell tumors Short Name Increase, Leydig cell tumors	1	Cellular	Nov 29, 2016	Sep 16, 2017	2 AOPs 111: Decrease in androgen receptor activity leading to Leydig cell tumors (in rat) 120: Inhibition of 5α-reductase leading to Leydig cell tumors (in rat)
744	Increase, Hyperplasia (Leydig cells) Short Name Increase, Hyperplasia (Leydig cells)	1	Cellular	Nov 29, 2016	Sep 16, 2017	2 AOPs 111: Decrease in androgen receptor activity leading to Leydig cell tumors (in rat) 120: Inhibition of 5α-reductase leading to Leydig cell tumors (in rat)
743	Decreased, Testosterone binding to androgen receptor (hypothalamus) Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	111: Decrease in androgen receptor activity leading to Leydig cell tumors (in rat)
741	Increase, Adenomas/carcinomas (follicular cell) Short Name	2	Tissue	Nov 29, 2016	Sep 16, 2017	3 AOPs 110: Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse) 119: Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse) 162: Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse
740	Increase, Hyperplasia (follicular cells) Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	3 AOPs 110: Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse) 119: Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse) 162: Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse
739	Increase, Hypertrophy and proliferation (follicular cell) Short Name	2	Cellular	Nov 29, 2016	Sep 16, 2017	3 AOPs 110: Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse) 119: Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse) 162: Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse
737	Decreased, Uptake of inorganic iodide Short Name Decreased, Uptake of inorganic iodide	1	Cellular	Nov 29, 2016	Sep 16, 2017	None
736	Increase, Adenomas/carcinomas (bronchioloalveolar) Short Name	2	Tissue	Nov 29, 2016	Sep 16, 2017	109: Cytotoxicity leading to bronchioloalveolar adenomas and carcinomas (in mouse)
735	Increase, Hyperplasia (terminal bronchiolar cells) Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	109: Cytotoxicity leading to bronchioloalveolar adenomas and carcinomas (in mouse)
734	Increase, Regenerative cell proliferation (terminal bronchiolar epithelial cells) Short Name	1	Cellular	Nov 29, 2016	Dec 3, 2016	109: Cytotoxicity leading to bronchioloalveolar adenomas and carcinomas (in mouse)
733	Increase, Necrosis (terminal bronchiolar cells) Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	109: Cytotoxicity leading to bronchioloalveolar adenomas and carcinomas (in mouse)
728	Increase, Aneuploid offspring Short Name Increase, Aneuploid offspring	1	Individual	Nov 29, 2016	May 27, 2019	106: Chemical binding to tubulin in oocytes leading to aneuploid offspring
726	Increased, Induction of pyruvate dehydrogenase (PDH) Short Name	1	Molecular	Nov 29, 2016	Dec 3, 2016	108: Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat)
724	Inhibition, Pyruvate dehydrogenase kinase (PDK) enzyme Short Name	1	Cellular	Nov 29, 2016	Dec 3, 2016	108: Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat)
723	Altered, Chromosome number Short Name Altered, Chromosome number	1	Cellular	Nov 29, 2016	May 27, 2019	106: Chemical binding to tubulin in oocytes leading to aneuploid offspring
721	Disorganization, Meiotic Spindle Short Name Disorganization, Meiotic Spindle	1	Cellular	Nov 29, 2016	Apr 20, 2021	106: Chemical binding to tubulin in oocytes leading to aneuploid offspring
720	Disruption, Microtubule dynamics Short Name Disruption, Microtubule dynamics	1	Molecular	Nov 29, 2016	Nov 7, 2019	106: Chemical binding to tubulin in oocytes leading to aneuploid offspring
719	Increase, hepatocellular adenomas and carcinomas Short Name	3	Tissue	Nov 29, 2016	Dec 26, 2020	5 AOPs 107: Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat 108: Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat) 117: Androgen receptor activation leading to hepatocellular adenomas and carcinomas (in mouse and rat) 118: Chronic cytotoxicity leading to hepatocellular adenomas and carcinomas (in mouse and rat) 37: PPARα activation leading to hepatocellular adenomas and carcinomas in rodents