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All Key Events

Showing 1576 to 1600 of 1921 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

675	Reduced, Reproductive Success Short Name Reduced, Reproductive Success	2	Individual	Nov 29, 2016	Dec 3, 2016	5 AOPs 100: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior 101: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release 63: Cyclooxygenase inhibition leading to reproductive dysfunction 102: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition 103: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint
674	Reduced, Ability to attract spawning mates Short Name	1	Individual	Nov 29, 2016	Dec 3, 2016	2 AOPs 100: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior 101: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release
673	Reduced, Spawning behavior Short Name Reduced, Spawning behavior	1	Individual	Nov 29, 2016	Dec 3, 2016	100: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior
672	Reduced, Prostaglandin F2alpha synthesis, ovary Short Name	1	Organ	Nov 29, 2016	Sep 16, 2017	100: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior
671	Reduced, Prostaglandin F2alpha concentration, plasma Short Name	1	Individual	Nov 29, 2016	Dec 3, 2016	2 AOPs 100: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior 101: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release
669	Reduction, Neuronal synaptic inhibition Short Name Reduction, Neuronal synaptic inhibition	1	Cellular	Nov 29, 2016	May 16, 2018	10: Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain
667	Binding at picrotoxin site, iGABAR chloride channel Short Name	3	Molecular	Nov 29, 2016	Apr 29, 2019	10: Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain
664	Overwhelmed, Mitochondrial DNA repair mechanisms Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	80: Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure
663	Desensitization, Nicotinic acetylcholine receptor Short Name	2	Molecular	Nov 29, 2016	Jun 7, 2018	3 AOPs 89: Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure 88: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste 90: Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2
662	Decreased testosterone by the fetal Leydig cells, Hypermethylation in the fetal testis Short Name	1	Molecular	Nov 29, 2016	Dec 3, 2016	74: Modulation of Adult Leydig Cell Function Subsequent to Hypermethylation in the Fetal Testis
661	Decreased testosterone by the fetal Leydig cells, Alterations in the fetal testis proteome Short Name	1	Molecular	Nov 29, 2016	Dec 3, 2016	68: Modulation of Adult Leydig Cell Function Subsequent to Alterations in the Fetal Testis Protome
660	decreased testosterone by fetal Leydig cells, Dysgenesis of fetal Leydig cells Short Name	2	Organ	Nov 29, 2016	Sep 16, 2017	67: Modulation of Adult Leydig Cell Function Subsequent to Estradiaol Activation in the Fetal Testis
659	Decreased testosterone by the fetal Leydig cells, Activation by other estradiol agonists Short Name	1	Cellular	Nov 29, 2016	Dec 3, 2016	67: Modulation of Adult Leydig Cell Function Subsequent to Estradiaol Activation in the Fetal Testis
658	Decreased testosterone by the fetal Leydig cells, Increased estradiol Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	67: Modulation of Adult Leydig Cell Function Subsequent to Estradiaol Activation in the Fetal Testis
657	Decreased testosterone by the fetal Leydig cells, Dysgenesis of fetal Leydig cells Short Name	2	Organ	Nov 29, 2016	Dec 3, 2016	2 AOPs 66: Modulation of Adult Leydig Cell Function Subsequent Glucocorticoid Activation in the Fetal Testis 68: Modulation of Adult Leydig Cell Function Subsequent to Alterations in the Fetal Testis Protome
656	Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) Short Name Decreased COUP-TFII in Leydig cells	1	Cellular	Nov 29, 2016	Dec 3, 2024	5 AOPs 66: Modulation of Adult Leydig Cell Function Subsequent Glucocorticoid Activation in the Fetal Testis 67: Modulation of Adult Leydig Cell Function Subsequent to Estradiaol Activation in the Fetal Testis 68: Modulation of Adult Leydig Cell Function Subsequent to Alterations in the Fetal Testis Protome 526: Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) leads to Impaired, Spermatogenesis 527: Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) leads to Hypospadias, increased
655	Decreased testosterone by the fetal Leydig cells, Increased COUP-TFII in fetal Leydig cells Short Name	1	Cellular	Nov 29, 2016	Dec 3, 2016	4 AOPs 66: Modulation of Adult Leydig Cell Function Subsequent Glucocorticoid Activation in the Fetal Testis 67: Modulation of Adult Leydig Cell Function Subsequent to Estradiaol Activation in the Fetal Testis 68: Modulation of Adult Leydig Cell Function Subsequent to Alterations in the Fetal Testis Protome 74: Modulation of Adult Leydig Cell Function Subsequent to Hypermethylation in the Fetal Testis
654	Decreased testosterone by the fetal Leydig cells, Activation by other glucocorticoid receptor agonists Short Name	1	Cellular	Nov 29, 2016	Dec 3, 2016	66: Modulation of Adult Leydig Cell Function Subsequent Glucocorticoid Activation in the Fetal Testis
653	Decreased testosterone by the fetal Leydig cells, Increased corticosterone Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	66: Modulation of Adult Leydig Cell Function Subsequent Glucocorticoid Activation in the Fetal Testis
652	Direct effects of Corticosterone on steroidogenesis, Decreased testosterone by adult Leydig cells Short Name	1	Cellular	Nov 29, 2016	Dec 3, 2016	71: Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation
651	Glucocorticoid Receptor mediated alterations in steriodogenic enzymes, Decreased testosterone by adult Leydig cells Short Name	1	Cellular	Nov 29, 2016	Dec 3, 2016	71: Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation
650	Stimulation of adult Leydig cells via the Adrenal Corticosterone, Increased Glucocorticoid Short Name	2	Molecular	Nov 29, 2016	Dec 3, 2016	71: Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation
649	Decreased steroidogenesis, Alterations in the Leydig Cell Cytoskeleton Short Name	1	Tissue	Nov 29, 2016	Sep 16, 2017	70: Modulation of Adult Leydig Cell Function Subsequent to Proteomic Alterations in the Adult Leydig Cell
648	Decreased steroidogenesis, Increased Apoptosis of Adult Leydig Cells Short Name	1	Tissue	Nov 29, 2016	Sep 16, 2017	70: Modulation of Adult Leydig Cell Function Subsequent to Proteomic Alterations in the Adult Leydig Cell
647	Decreased, steroidogenic protein expression Short Name	1	Cellular	Nov 29, 2016	Dec 3, 2024	3 AOPs 70: Modulation of Adult Leydig Cell Function Subsequent to Proteomic Alterations in the Adult Leydig Cell 526: Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) leads to Impaired, Spermatogenesis 527: Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) leads to Hypospadias, increased