AOP-Wiki

API

All Key Events

Showing 201 to 225 of 1921 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

2223	Reduced number of oligodendrocytes Short Name Reduced number of oligodendrocytes	0	Cellular	Apr 12, 2024	Apr 12, 2024	525: Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory
2222	Altered peroxisome proliferator–activated receptor alpha activity Short Name PPAR alpha activity, altered	0	Molecular	Apr 12, 2024	Apr 12, 2024	525: Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory
2221	Altered Liver X receptor activity Short Name LXR activity, altered	0	Molecular	Apr 12, 2024	Apr 12, 2024	525: Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory
2220	Antagonism, Glucocorticoid hormone receptor Short Name GR antagonism	0	Molecular	Apr 12, 2024	Apr 12, 2024	525: Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory
2219	Binding of (ant)agonist to peroxisome proliferator–activated receptor alpha Short Name Binding of (ant)agonist to PPAR alpha	0	Molecular	Apr 12, 2024	Apr 12, 2024	525: Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory
2218	Binding of (ant)agonist to liver X receptor Short Name	0	Molecular	Apr 12, 2024	Apr 12, 2024	525: Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory
2217	Binding of antagonist to glucocorticoid hormone receptor Short Name	0	Molecular	Apr 12, 2024	Apr 12, 2024	525: Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory
2216	Binding of antagonist to thyroid hormone receptor Short Name	0	Molecular	Apr 12, 2024	Apr 12, 2024	525: Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory
2215	Decrease Left Ventricular function Short Name Decrease LV function	0	Organ	Apr 3, 2024	Apr 3, 2024	2 AOPs 479: Mitochondrial complexes inhibition leading to left ventricular function decrease via increased myocardial oxidative stress 480: Mitochondrial complexes inhibition leading to heart failure via decreased ATP production
2214	Decreased, Insulin-like peptide 3 (INSL3) Short Name Decreased, INSL3	1	Molecular	Mar 19, 2024	Dec 3, 2024	528: Decreased Insulin-like peptide 3 (INSL3) leads to Malformation, cryptorchidism - maldescended testis
2213	Impaired, urethral tube closure Short Name Impaired, urethral tube closure	1	Organ	Mar 19, 2024	Dec 3, 2024	527: Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) leads to Hypospadias, increased
2212	Epididymal agenesis Short Name Epididymal agenesis	1	Organ	Mar 19, 2024	Dec 3, 2024	526: Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) leads to Impaired, Spermatogenesis
2211	Microcephaly Short Name Microcephalus	0	Organ	Feb 2, 2024	Feb 2, 2024	581: Glucocorticoid receptor (GR) activation during development leads to cognitive function (COG) decrease
2210	Reduced cortical thickness Short Name Reduced cortical thickness	0	Tissue	Feb 2, 2024	Feb 2, 2024	523: Retinoic acid receptor agonism during neurodevelopment leading to microcephaly
2209	autism-like behavior Short Name autism-like behavior	0	Individual	Jan 25, 2024	Jan 25, 2024	522: Estrogen antagonism leading to increased risk of autism-like behavior
2208	Aberrant, synaptic formation and plasticity Short Name	0	Organ	Jan 25, 2024	Jan 25, 2024	2 AOPs 522: Estrogen antagonism leading to increased risk of autism-like behavior 535: Binding and activation of GPER leading to learning and memory impairments
2207	inhibition, EKR1/2 signaling pathway Short Name inhibition, EKR1/2 signaling pathway	0	Cellular	Jan 25, 2024	Jan 25, 2024	522: Estrogen antagonism leading to increased risk of autism-like behavior
2206	Increased, histomorphological alteration of testis Short Name	1	Tissue	Jan 24, 2024	Apr 10, 2024	521: Essential element imbalance leads to reproductive failure via oxidative stress
2205	Increased, essential element imbalance Short Name Increased, essential element imbalance	0	Molecular	Jan 24, 2024	May 9, 2024	521: Essential element imbalance leads to reproductive failure via oxidative stress
2204	Altered brain morphology Short Name Altered brain morphology	0	Organ	Jan 14, 2024	Jan 14, 2024	520: Retinoic acid receptor agonism during neurodevelopment leading to impaired learning and memory
2203	Decreased proliferation of cortical neural progenitor cells Short Name	0	Cellular	Jan 14, 2024	Jan 29, 2024	3 AOPs 520: Retinoic acid receptor agonism during neurodevelopment leading to impaired learning and memory 523: Retinoic acid receptor agonism during neurodevelopment leading to microcephaly 581: Glucocorticoid receptor (GR) activation during development leads to cognitive function (COG) decrease
2202	Altered expression of cell cycle genes Short Name Altered expression of cell cycle genes	0	Molecular	Jan 14, 2024	Mar 7, 2024	3 AOPs 520: Retinoic acid receptor agonism during neurodevelopment leading to impaired learning and memory 523: Retinoic acid receptor agonism during neurodevelopment leading to microcephaly 581: Glucocorticoid receptor (GR) activation during development leads to cognitive function (COG) decrease
2201	Agonism, Retinoic acid receptor Short Name RAR agonism	0	Molecular	Jan 14, 2024	Jan 24, 2024	3 AOPs 520: Retinoic acid receptor agonism during neurodevelopment leading to impaired learning and memory 523: Retinoic acid receptor agonism during neurodevelopment leading to microcephaly 532: Retinoic acid receptor agonism during cerebellar development leading to impaired locomotor function
2200	decline, neural progenitor cells Short Name decline, neural progenitor cells	0	Organ	Jan 10, 2024	Jan 10, 2024	441: Ionizing radiation-induced DNA damage leads to microcephaly via apoptosis and premature cell differentiation
2199	Increased, Expression of LXR activated genes Short Name	1	Molecular	Dec 7, 2023	Mar 29, 2024	518: Liver X Receptor (LXR) activation leads to liver steatosis