| 2.7 |
May 30, 2024 |
Digital Copy, v2.7
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- New functionalities available for the OECD Secretariat
- Option to upload Scientific Review Reports for individual AOPs.
- Option to add links to iLibrary documents and Journal-formatted articles for individual AOPs.
- New AOP Page features and layout updates, inspired by eAOP Portal features
- New option to view Scientific Review Reports for each AOP.
- Addition of OECD-defined links to individual AOP iLibrary pages and Journal-formatted articles, included in the OECD Information Table (a replacement for the Status table).
- The Handbook Version number is now part of the Title section.
- Redesign of the OECD AOP Search Page
- Addition of new content for each AOP, including creation date, last date modified, and associated Key Events.
- Implementation of a new option to filter AOPs by OECD status.
- Updates to both the Key Event and Key Event Relationship search result tables to include the creation date and the last date modified.
- Updates to the AOP-Wiki Metrics Page
- Count for Users with Author Privileges is now available.
- New summary charts for AOP OECD Status Counts and AOP Entity Counts.
- New option to download a CSV version of the chart metrics for each chart.
- XML exports now include the new fields that were added in release 2.5 and 2.6.
- Missing quarterly XML downloads from July and October, 2023 have been reinstated.
In addition to the updates listed above that are visible to AOP-Wiki users, release 2.7 includes a major update to the server-side infrastructure, introducing Docker containers and other server upgrades detailed below.
- Server OS transition from Amazon Linux to Ubuntu 22.04.3 LTS
- Introduced Docker container network.
- Organized into three services.
- App – hosts the Rails application.
- DB – host a MySQL database.
- Solr – hosts the SOLR index to support full-text search.
- Migrated cronjob scripts into Docker setup.
- Includes database and log backups, gardener notifications, XML report downloads, and nightly tasks.
- Changed web server from Apache to Nginx to implement reverse proxy for the Docker network.
- Switch from Passenger to Puma as the internal web application server
- Updated EC2 instance and storage
- Old production instance: m4.large
- OS: Amazon Linux 1
- 2 vCPUs
- 8 GB RAM
- Up to 2.4 GHz Intel processors
- 450 Mbps EBS bandwidth
- 100 GB EBS volume – gp2
- New production instance: m6a.large
- OS: Ubuntu 22.04
- 2 vCPUs
- 8 GB RAM
- Up to 3.6 GHz AMD processors
- 10 Gbps EBS bandwidth
- 100 GB EBS volume – gp3
- MySQL upgrade from v5.6.50 to v8.0.30
- SOLR upgrade from v6.4.1to v9.1.1
Updates to the User Acceptance Test (UAT) document
- Tests added to cover new 2.7 features.
- Updated 3 tests to align with recent changes to the AOP-Wiki
 AOP-Wiki 2.7_release_notes_v2.pdf
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| 2.6 |
April 29, 2023 |
Digital Copy, v2.6
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- New informational section on Review and Endorsement of AOP-Wiki Content added (page 8).
- Section provides basic information on ways to request peer review of content developed in the AOP-Wiki, and potentially added to the OECD workplan and considered for endorsement.
- New informational section on Content Licensing added (page 9).
- Provides an overview of the license options that can be applied to AOP, Event, and Relationship pages in the AOP-Wiki, and rules/restrictions related to changing license selections over the course of AOP development.
- Author status and SAAOP status fields eliminated from the AOP-Wiki and Handbook.
- Author status has been replaced with relevant licensing options.
- SAAOP status was not being actively used and has been eliminated.
- Coach(es) field was added (page 15).
- Identification of coaches provides acknowledgement of the volunteer contributions made by the coach(es) and professional recognition.
- Handbook Version was added to the “Status” table on the AOP pages (page 15).
- The users can select the version of the AOP Handbook that was used to guide their AOP development.
- This provides coaches, technical peer-reviewers, and users awareness of the guidance that was followed during development.
- Authors are not required to update their AOPs based on the most current version of the Handbook, they need only comply with the Handbook version that corresponded to the date of creation of their AOP in the AOP-Wiki, or newer.
Handbook v2.6 change notes.pdf
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| 2.5 |
July 15, 2022 |
Digital Copy, v2.5
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- Added section to define the AOP development strategy
- Stressors replace with Prototypical Stressors
- Guidance for Evidence Collection Strategy for Key Event Relationships
- Guidance for describing modulating factors for Key Event Relationships and AOPs
- Introduced tabular format for summarizing evidence supporting essentiality of Key Events
- Guidance for discussing potential applications of AOPs
AOP_Developers_Handbook_2.5_release_notes.pdf
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| 2.0 |
February 14, 2018 |
AOP_Handbook_release_2018.pdf
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OECD (2018), "Users' Handbook supplement to the Guidance Document for developing and assessing Adverse Outcome Pathways", OECD Series on Adverse Outcome Pathways, No. 1, OECD Publishing, Paris, https://doi.org/10.1787/5jlv1m9d1g32-en.
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| 1.0 |
September 25, 2014 |
AOP_Handbook_September_25_2014_release.pdf
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This document is a supplement to the Guidance Document for developing and assessing Adverse Outcome Pathways (AOPs) [ENV/JM/MONO(2013)6] (AOP guidance hereafter). The AOP Guidance, published in 2013, only one year after the OECD programme on the development of AOPs was initiated, was considered a first version which would be revised as expert groups and member countries gained experience in developing and assessing AOPs. This handbook contains an updated template for AOP development and provides focused and practical instructions for both AOP developers and reviewers and is intended to assist in identifying, organising and evaluating critical information on key events (KE) as well as linkages between KEs within the AOP (i.e., AOP development). It also provides more evolved and explicit guidance on how to assess the weight of evidence (WOE) (degree of confidence) supporting the overall AOP and its relevance for life stage, sex and taxonomy (i.e., AOP evaluation). The handbook is intended to be used as a supplement to the AOP guidance and a replacement for the AOP Template (Part II of the guidance) and evaluation for which improvement was needed.
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