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Showing 476 to 500 of 3102 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

1986	1691: Antagonism,LH receptor	1692: Reduction, Progesterone synthesis	Oct 3, 2019	Oct 3, 2019	1 AOP 309: Luteinizing hormone receptor antagonism leading to reproductive dysfunction
1194	1148: Anticoagulant rodenticide interferes with gamma-carboxyglutamate formation, Inhibition of p	1149: Calcium cannot bind to the hydroxyapatite matrix of bone, Osteocalcin and other bone protei	Nov 29, 2016	Dec 3, 2016	None
1368	1262: Apoptosis	1277: Reproductive failure	Feb 15, 2017	Feb 15, 2017	1 AOP 207: NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans
1713	1262: Apoptosis	1506: Testicular atrophy	Jan 21, 2018	Jan 21, 2018	None
1735	1262: Apoptosis	1515: Spermatocyte depletion	May 22, 2018	Jul 28, 2021	1 AOP 212: Histone deacetylase inhibition leading to testicular atrophy
1867	1262: Apoptosis	1606: Activation, Stellate cell	Mar 6, 2019	Mar 6, 2019	1 AOP 285: Inhibition of N-linked glycosylation leads to liver injury
1869	1262: Apoptosis	1549: Liver Injury	Mar 6, 2019	Mar 6, 2019	1 AOP 285: Inhibition of N-linked glycosylation leads to liver injury
2191	1262: Apoptosis	1809: Increase, Tissue/organ damage	Nov 2, 2020	Nov 2, 2020	None
2577	1262: Apoptosis	1971: tumor growth	Feb 15, 2022	Mar 5, 2024	1 AOP 439: Activation of the AhR leading to metastatic breast cancer
2675	1262: Apoptosis	2011: Emphysema	Jun 17, 2022	Jun 17, 2022	1 AOP 452: Adverse outcome pathway of PM-induced respiratory toxicity
2792	1262: Apoptosis	2041: Decrease, facial prominence outgrowth	Oct 27, 2022	Apr 4, 2025	2 AOPs 460: Antagonism of Smoothened receptor leading to orofacial clefting 491: Decrease, GLI1/2 target gene expression leads to orofacial clefting
2967	1262: Apoptosis	352: N/A, Neurodegeneration	Jul 18, 2023	Apr 11, 2024	1 AOP 500: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis
3106	1262: Apoptosis	2200: decline, neural progenitor cells	Jan 10, 2024	Jan 10, 2024	1 AOP 441: Ionizing radiation-induced DNA damage leads to microcephaly via apoptosis and premature cell differentiation
3250	1262: Apoptosis	2208: Aberrant, synaptic formation and plasticity	Jun 19, 2024	Jun 19, 2024	1 AOP 535: Binding and activation of GPER leading to learning and memory impairments
3251	1262: Apoptosis	2151: Disruption, neurotransmitter release	Jun 19, 2024	Jun 19, 2024	1 AOP 535: Binding and activation of GPER leading to learning and memory impairments
3257	1262: Apoptosis	188: Neuroinflammation	Jun 19, 2024	Jun 19, 2024	1 AOP 535: Binding and activation of GPER leading to learning and memory impairments
3327	1262: Apoptosis	3: Reduction, 17beta-estradiol synthesis by ovarian granulosa cells	Jul 26, 2024	Jul 26, 2024	1 AOP 540: Oxidative Stress in the Fish Ovary Leads to Reproductive Impairment via Reduced Vitellogenin Production
3468	1262: Apoptosis	1883: Decreased, ovarian reserve	Jan 4, 2025	May 31, 2025	1 AOP 563: Aryl hydrocarbon Receptor (AHR) activation causes Premature Ovarian Insufficiency via Bax mediated apoptosis
3693	1262: Apoptosis	2391: Reduced fertility	Nov 7, 2025	Nov 7, 2025	1 AOP 616: organic UV filter and its Photoproducts reproductive toxicity pathways
3759	1262: Apoptosis	344: Increase, Liver fibrosis	Mar 25, 2026	Mar 25, 2026	1 AOP 638: Co-exposure to microplastics and cadmium leading to progression from NAFLD to liver tumorigenesis
3760	1262: Apoptosis	1395: Liver Cancer	Mar 25, 2026	Mar 25, 2026	1 AOP 638: Co-exposure to microplastics and cadmium leading to progression from NAFLD to liver tumorigenesis
2198	1817: Apoptotic cell death	1633: Increase in inflammation	Nov 2, 2020	Nov 2, 2020	1 AOP 362: Immune mediated hepatitis
3436	2293: Aromatase, induction	1076: Increased, circulating estrogen levels	Nov 22, 2024	Dec 16, 2024	1 AOP 561: Aromatase induction leading to estrogen receptor alpha activation via increased estradiol
2192	1814: Reactive Metabolite	1816: Mitochondrial dysfunction EMPTY	Nov 2, 2020	Nov 2, 2020	None
2194	1814: Reactive Metabolite	1818: Immune cell activation	Nov 2, 2020	Nov 2, 2020	1 AOP 362: Immune mediated hepatitis

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