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Showing 1751 to 1775 of 3102 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

2810	1392: Increase, Oxidative Stress	1634: Increase, Oxidative DNA damage	Dec 16, 2022	Mar 8, 2024	2 AOPs 478: Deposition of energy leading to occurrence of cataracts 602: Excessive reactive oxygen species leading to growth inhibition via oxidative DNA damage
2811	1392: Increase, Oxidative Stress	1635: Increase, DNA strand breaks	Dec 16, 2022	Jul 29, 2024	3 AOPs 478: Deposition of energy leading to occurrence of cataracts 483: Deposition of Energy Leading to Learning and Memory Impairment 470: Deposition of energy leads to abnormal vascular remodeling
2812	1392: Increase, Oxidative Stress	2081: Modified Proteins	Dec 16, 2022	Mar 30, 2023	1 AOP 478: Deposition of energy leading to occurrence of cataracts
2818	1392: Increase, Oxidative Stress	2083: Cataracts	Dec 18, 2022	Mar 11, 2024	1 AOP 478: Deposition of energy leading to occurrence of cataracts
2827	1392: Increase, Oxidative Stress	1816: Mitochondrial dysfunction EMPTY	Jan 9, 2023	Jan 9, 2023	None
2833	1392: Increase, Oxidative Stress	1492: Tissue resident cell activation	Jan 25, 2023	Jul 26, 2024	1 AOP 483: Deposition of Energy Leading to Learning and Memory Impairment
2846	1392: Increase, Oxidative Stress	2089: Altered Bone Cell Homeostasis	Jan 25, 2023	Aug 12, 2024	1 AOP 482: Deposition of energy leading to occurrence of bone loss
2975	1392: Increase, Oxidative Stress	149: Increase, Inflammation	Jul 31, 2023	Oct 19, 2023	2 AOPs 505: Reactive Oxygen Species (ROS) formation leads to cancer via inflammation pathway 472: DNA adduct formation leading to kidney failure
3047	1392: Increase, Oxidative Stress	1605: Accumulation, misfolded proteins	Sep 14, 2023	Sep 14, 2023	1 AOP 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
3048	1392: Increase, Oxidative Stress	1585: Proteasomal dysfunction	Sep 14, 2023	Sep 14, 2023	1 AOP 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
3116	1392: Increase, Oxidative Stress	1445: Increase, LPO	Jan 24, 2024	Apr 11, 2024	4 AOPs 521: Essential element imbalance leads to reproductive failure via oxidative stress 331: Excessive reactive oxygen species leading to growth inhibition via lipid peroxidation and cell death 332: Excessive reactive oxygen species leading to growth inhibition via lipid peroxidation and reduced cell growth 333: Excessive reactive oxygen species leading to growth inhibition via lipid peroxidation and reduced cell proliferation
3129	1392: Increase, Oxidative Stress	177: Increase, Mitochondrial dysfunction	Feb 17, 2024	May 31, 2024	6 AOPs 481: AOPs of amorphous silica nanoparticles: ROS-mediated oxidative stress increased respiratory dysfunction and diseases. 437: Inhibition of mitochondrial electron transport chain (ETC) complexes leading to kidney toxicity 497: ERa inactivation alters mitochondrial functions and insulin signalling in skeletal muscle and leads to insulin resistance and metabolic syndrome 509: Nrf2 inhibition leading to vascular disrupting effects through activating apoptosis signal pathway and mitochondrial dysfunction 511: The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects 595: Emerging OPFRS reproductive outcome pathway
3239	1392: Increase, Oxidative Stress	1775: Increase, Oocyte apoptosis	May 31, 2024	May 31, 2024	1 AOP 396: Deposition of ionizing energy leads to population decline via impaired meiosis
3249	1392: Increase, Oxidative Stress	1262: Apoptosis	Jun 19, 2024	Jun 19, 2024	2 AOPs 535: Binding and activation of GPER leading to learning and memory impairments 540: Oxidative Stress in the Fish Ovary Leads to Reproductive Impairment via Reduced Vitellogenin Production
3252	1392: Increase, Oxidative Stress	188: Neuroinflammation	Jun 19, 2024	Jun 19, 2024	1 AOP 535: Binding and activation of GPER leading to learning and memory impairments
3262	1392: Increase, Oxidative Stress	1032: Increased, secretion of local growth factors	Jul 3, 2024	Jul 3, 2024	1 AOP 171: Chronic cytotoxicity of the serous membrane leading to pleural/peritoneal mesotheliomas in the rat.
3264	1392: Increase, Oxidative Stress	1097: Occurrence, renal proximal tubular necrosis	Jul 3, 2024	Jul 3, 2024	4 AOPs 138: Organic anion transporter (OAT1) inhibition leading to renal failure and mortality 177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality 186: unknown MIE leading to renal failure and mortality 447: Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways
3267	1392: Increase, Oxidative Stress	1194: Increase, DNA Damage	Jul 4, 2024	Jul 4, 2024	2 AOPs 200: Estrogen receptor activation leading to breast cancer 444: Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability
3270	1392: Increase, Oxidative Stress	1365: Increase, Apoptosis	Jul 4, 2024	Jul 4, 2024	2 AOPs 444: Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability 509: Nrf2 inhibition leading to vascular disrupting effects through activating apoptosis signal pathway and mitochondrial dysfunction
3272	1392: Increase, Oxidative Stress	2144: Impaired insulin signaling	Jul 4, 2024	Jul 4, 2024	1 AOP 497: ERa inactivation alters mitochondrial functions and insulin signalling in skeletal muscle and leads to insulin resistance and metabolic syndrome
3274	1392: Increase, Oxidative Stress	277: TH synthesis, Decreased	Jul 4, 2024	Jul 4, 2024	2 AOPs 457: Succinate dehydrogenase inhibition leading to increased insulin resistance through reduction in circulating thyroxine 459: AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals
3277	1392: Increase, Oxidative Stress	2009: Activation, inflammation pathway	Jul 4, 2024	Jul 4, 2024	2 AOPs 507: Nrf2 inhibition leading to vascular disrupting effects via inflammation pathway 511: The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects
3279	1392: Increase, Oxidative Stress	2166: Abnormal expression of NO	Jul 4, 2024	Jul 4, 2024	1 AOP 510: Demethylation of PPAR promotor leading to vascular disrupting effects
3280	1392: Increase, Oxidative Stress	2170: Activated ANG/Tie2 pathway	Jul 4, 2024	Jul 4, 2024	1 AOP 511: The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects
3281	1392: Increase, Oxidative Stress	2164: Activation, Dll4-Notch pathway	Jul 4, 2024	Jul 4, 2024	1 AOP 511: The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects

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