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All KERs

Showing 1976 to 2000 of 3164 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

1586	1433: Increased CGRP	1225: Leukocyte infiltration	Jun 23, 2017	Jun 23, 2017	None
1587	1433: Increased CGRP	1226: Respiratory irritability	Jun 27, 2017	Jun 27, 2017	1 AOP 196: Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation
51	39: Increased Cholinergic Signaling	360: Decrease, Population growth rate	Nov 29, 2016	Dec 3, 2016	None
434	39: Increased Cholinergic Signaling	351: Increased Mortality	Nov 29, 2016	Dec 3, 2016	None
457	39: Increased Cholinergic Signaling	445: Respiratory distress/arrest	Nov 29, 2016	Dec 20, 2019	1 AOP 16: Acetylcholinesterase inhibition leading to acute mortality
2005	39: Increased Cholinergic Signaling	1703: Cardiovascular dysregulation	Nov 25, 2019	Dec 20, 2019	1 AOP 16: Acetylcholinesterase inhibition leading to acute mortality
2011	39: Increased Cholinergic Signaling	1705: Impaired coordination and movement	Dec 20, 2019	Dec 20, 2019	1 AOP 312: Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement
2410	39: Increased Cholinergic Signaling	386: Neuronal network function, Decreased	Jun 24, 2021	Sep 1, 2021	1 AOP 405: Organo-Phosphate Chemicals induced inhibition of AChE leading to impaired cognitive function
2412	39: Increased Cholinergic Signaling	402: Cognitive function, decreased	Jun 24, 2021	Sep 1, 2021	1 AOP 405: Organo-Phosphate Chemicals induced inhibition of AChE leading to impaired cognitive function
3747	2371: Increased cortisol	1335: Reduced, BDNF	Mar 19, 2026	Mar 19, 2026	1 AOP 604: Binding of Alpha 1-Adrenergics to Agonists Leading to Depression
3405	2280: Prolonged atrioventricular (AV)	1106: Occurrence, cardiac arrhythmia	Nov 20, 2024	Nov 20, 2024	2 AOPs 551: Increased Muscarinic M2 Receptor leading to Arrhythmia 559: Inhibition of acetylcholinesterase (AChE) leading to arrhythmias
2031	1723: Increased acinar cell exocrine secretion	1724: Acinar cell proliferation	Jan 8, 2020	Jan 8, 2020	1 AOP 316: Trypsin inhibition leading to pancreatic acinar cell tumors
2876	2125: Increased fat mass	1497: Recruitment of inflammatory cells	Apr 5, 2023	Apr 5, 2023	1 AOP 493: ERa inactivation alters AT expansion and functions and leads to insulin resistance and metabolically unhealthy obesity
2901	2125: Increased fat mass	2132: Increased cytokine expression	May 4, 2023	May 4, 2023	1 AOP 493: ERa inactivation alters AT expansion and functions and leads to insulin resistance and metabolically unhealthy obesity
1953	1661: Homocysteine increases	1662: plasma homocysteine increases	Jun 14, 2019	Jun 14, 2019	None
1959	1661: Homocysteine increases	1665: Plasma HCY level	Jul 3, 2019	Jul 3, 2019	1 AOP 301: Inhibition of Cystathionine Beta synthase leading to impaired the early development of anterior-posterior axis
2062	1750: Increased inflammatory immune responses	1748: Increase, the risk of acute respiratory failure	Mar 10, 2020	Mar 10, 2020	1 AOP 320: Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality
2513	1750: Increased inflammatory immune responses	1934: Heart attack	Oct 28, 2021	Oct 28, 2021	None
2029	1721: Increased monitor peptide	1722: Increased blood CCK level	Jan 8, 2020	Jan 8, 2020	1 AOP 316: Trypsin inhibition leading to pancreatic acinar cell tumors
2940	2149: Increased intracelluar Iron	191: Neuronal dysfunction	Jun 15, 2023	Jun 15, 2023	1 AOP 498: Increased LCN2/iron complex leading to neurological disorders
3313	2149: Increased intracelluar Iron	1392: Increase, Oxidative Stress	Jul 23, 2024	Jul 23, 2024	1 AOP 501: Excessive iron accumulation leading to neurological disorders
2627	1985: Increased Kisspeptin levels in AVPV	1986: Decreased, Gonadotropins	Apr 5, 2022	Aug 15, 2022	1 AOP 445: Estrogen Receptor Alpha Agonism leads to Impaired Reproduction
3714	1985: Increased Kisspeptin levels in AVPV	1047: Increased, secretion of GnRH from hypothalamus	Jan 29, 2026	Jun 2, 2026	4 AOPs 623: Activation, estrogen receptor alpha leads to persistent vaginal cornification via increased kisspeptin release 637: Activation, estrogen receptor alpha leads to increased uterine weight via earlier proliferation of cells of the uterine lining 639: Activation, estrogen receptor alpha leads to precocious puberty via increased kisspeptin release 640: Activation, estrogen receptor alpha leads to decreased fertility via prolonged estrus cycle
2939	2148: Increased LCN2/iron complex	2149: Increased intracelluar Iron	Jun 15, 2023	Jun 15, 2023	1 AOP 498: Increased LCN2/iron complex leading to neurological disorders
2900	2130: increased lipid accumulation	2125: Increased fat mass	May 4, 2023	May 4, 2023	1 AOP 493: ERa inactivation alters AT expansion and functions and leads to insulin resistance and metabolically unhealthy obesity

Key Event Relationships (KERs)

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