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Showing 2176 to 2200 of 3102 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

1266	1189: Increased, Proliferation (Endothelial cells)	1213: Increased, Angiogenesis	Nov 29, 2016	Dec 20, 2022	1 AOP 200: Estrogen receptor activation leading to breast cancer
1076	1033: Increased, proliferation of mesenchymal cells	1035: Increased, Firbrosarcoma	Nov 29, 2016	Dec 3, 2016	1 AOP 163: PPARgamma activation leading to sarcomas in rats, mice, and hamsters
1077	1033: Increased, proliferation of mesenchymal cells	1036: Increased, liposarcoma	Nov 29, 2016	Dec 3, 2016	1 AOP 163: PPARgamma activation leading to sarcomas in rats, mice, and hamsters
1078	1033: Increased, proliferation of mesenchymal cells	1037: Increased, hemagiosarcoma	Nov 29, 2016	Dec 3, 2016	1 AOP 163: PPARgamma activation leading to sarcomas in rats, mice, and hamsters
343	377: Increased, Proliferation/Clonal Expansion of Mutant Cells (Pre-Neoplastic Lesions/Altered H	378: Tumorigenesis, Hepatocellular carcinoma	Nov 29, 2016	Nov 29, 2016	None
3389	2276: Increased, PCSK9 protein expression	2271: Increased, plasma LDL cholesterol	Nov 13, 2024	Feb 10, 2025	1 AOP 548: Activation, Pregnane-X receptor, NR1l2 leads to increased plasma low-density lipoprotein (LDL) cholesterol via increased PCSK9 protein expression
1463	1357: Increased, RDX dose	1359: Activate, GABA-A receptor	Apr 14, 2017	Apr 14, 2017	1 AOP 215: Molecular events lead to epilepsy
1555	1357: Increased, RDX dose	1415: Reduced, GABA-A receptor activation	Jun 2, 2017	Jun 2, 2017	1 AOP 231: presynaptic neuron 2 repression to epilepsy
1704	1497: Recruitment of inflammatory cells	1498: Loss of alveolar capillary membrane integrity	Jan 5, 2018	May 18, 2023	1 AOP 173: Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis
1964	1497: Recruitment of inflammatory cells	1115: Increase, ROS	Jul 3, 2019	Jul 3, 2019	2 AOPs 303: Frustrated phagocytosis-induced lung cancer 409: Frustrated phagocytosis leads to malignant mesothelioma
2354	1497: Recruitment of inflammatory cells	1868: Hyperinflammation	Apr 20, 2021	Feb 8, 2023	2 AOPs 392: Decreased fibrinolysis and activated bradykinin system leading to hyperinflammation 468: Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death)
2491	1497: Recruitment of inflammatory cells	1931: Disruption of the intestinal barrier	Oct 19, 2021	Oct 19, 2021	None
2492	1497: Recruitment of inflammatory cells	1932: GI disorders	Oct 19, 2021	Oct 19, 2021	None
2543	1497: Recruitment of inflammatory cells	1954: Gut dysbiosis	Dec 15, 2021	Dec 15, 2021	None
2658	1497: Recruitment of inflammatory cells	780: Increase, Cytotoxicity (epithelial cells)	May 25, 2022	May 25, 2022	1 AOP 451: Interaction with lung resident cell membrane components leads to lung cancer
2761	1497: Recruitment of inflammatory cells	1496: Increased proinflammatory mediators	Sep 1, 2022	Sep 1, 2022	1 AOP 468: Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death)
2903	1497: Recruitment of inflammatory cells	1633: Increase in inflammation	May 4, 2023	May 4, 2023	1 AOP 493: ERa inactivation alters AT expansion and functions and leads to insulin resistance and metabolically unhealthy obesity
1215	1163: Increased, Reproductive Success	1164: Increased, Population	Nov 29, 2016	Dec 3, 2016	2 AOPs 195: 5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase 204: 5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase
1308	1242: Increased, Second Messenger Production	1191: Increased, Non-genomic signaling	Nov 29, 2016	Dec 3, 2016	1 AOP 200: Estrogen receptor activation leading to breast cancer
1090	1049: Increased, secrection of FSH from anterior pituitary	1051: Hyperplasia, ovarian stromal cells	Nov 29, 2016	Dec 3, 2016	1 AOP 165: Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse
1091	1049: Increased, secrection of FSH from anterior pituitary	1052: Hyperplasia, ovarian epithelium	Nov 29, 2016	Dec 3, 2016	1 AOP 165: Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse
1088	1047: Increased, secretion of GnRH from hypothalamus	1049: Increased, secrection of FSH from anterior pituitary	Nov 29, 2016	Dec 3, 2016	1 AOP 165: Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse
1089	1047: Increased, secretion of GnRH from hypothalamus	1050: Increased, secretion of LH from anterior pituitary	Nov 29, 2016	Mar 1, 2022	2 AOPs 165: Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse 440: Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia
3715	1047: Increased, secretion of GnRH from hypothalamus	2137: Increase, Gonadotropins concentration in plasma	Jan 29, 2026	Feb 3, 2026	3 AOPs 623: Activation, estrogen receptor alpha leads to persistent vaginal cornification via increased kisspeptin release 637: Activation, estrogen receptor alpha leads to increased uterine weight via earlier proliferation of cells of the uterine lining 639: Activation, estrogen receptor alpha leads to precocious puberty via increased kisspeptin release
1092	1050: Increased, secretion of LH from anterior pituitary	1051: Hyperplasia, ovarian stromal cells	Nov 29, 2016	Dec 3, 2016	1 AOP 165: Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse

Key Event Relationships (KERs)

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