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Showing 2451 to 2475 of 3102 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

2003	202: Inhibition, Nuclear factor kappa B (NF-kB)	1702: Suppression of T cell activation	Nov 17, 2019	Mar 2, 2023	1 AOP 277: Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response
2306	202: Inhibition, Nuclear factor kappa B (NF-kB)	1496: Increased proinflammatory mediators	Mar 30, 2021	Mar 30, 2021	None
2644	202: Inhibition, Nuclear factor kappa B (NF-kB)	1633: Increase in inflammation	Apr 8, 2022	Apr 8, 2022	1 AOP 447: Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways
3698	202: Inhibition, Nuclear factor kappa B (NF-kB)	2394: Lower survival B lymphocytes	Dec 3, 2025	Dec 3, 2025	1 AOP 618: PPARgamma activation leads to a diminished vaccine response
3699	202: Inhibition, Nuclear factor kappa B (NF-kB)	2395: Diminished proliferation of activated B lymphocytes	Dec 3, 2025	Dec 3, 2025	1 AOP 618: PPARgamma activation leads to a diminished vaccine response
3700	202: Inhibition, Nuclear factor kappa B (NF-kB)	2396: Diminished differentiation of activated B lymphocytes	Dec 3, 2025	Dec 3, 2025	1 AOP 618: PPARgamma activation leads to a diminished vaccine response
1131	877: Inhibition, organic anion transporter 1 (OAT1)	1096: Increased, blood uric acid concentration	Nov 29, 2016	Dec 3, 2016	1 AOP 138: Organic anion transporter (OAT1) inhibition leading to renal failure and mortality
3652	2376: Inhibition, OATP1C1	2093: Decreased brain T4/T3	Oct 8, 2025	Oct 8, 2025	1 AOP 610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function
1202	1155: Inhibition, Pendrin	277: TH synthesis, Decreased	Nov 29, 2016	Dec 3, 2016	1 AOP 192: Pendrin inhibition leading to altered amphibian metamorphosis
836	828: Inhibition, Phospholipase A	829: Damage, Lipid bilayer	Nov 29, 2016	Dec 3, 2016	1 AOP 130: Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
837	828: Inhibition, Phospholipase A	831: Disturbance, Lysosomal function	Nov 29, 2016	Dec 3, 2016	1 AOP 130: Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
3154	828: Inhibition, Phospholipase A	177: Increase, Mitochondrial dysfunction	Mar 13, 2024	Mar 13, 2024	1 AOP 130: Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
511	468: Inhibition, PPAR alpha	451: Inhibition, Mitochondrial fatty acid beta-oxidation	Nov 29, 2016	Dec 3, 2016	1 AOP 58: NR1I3 (CAR) suppression leading to hepatic steatosis
799	798: Inhibition, Prolyl hydroxylases	799: Increased, HIF-1 heterodimer	Nov 29, 2016	Dec 3, 2016	1 AOP 122: Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation
3369	798: Inhibition, Prolyl hydroxylases	590: N/A, hypoxia	Oct 25, 2024	Oct 25, 2024	1 AOP 546: Succinate dehydrogenase inactivation leads to cancer through hypoxic-like mechanisms
716	724: Inhibition, Pyruvate dehydrogenase kinase (PDK) enzyme	726: Increased, Induction of pyruvate dehydrogenase (PDH)	Nov 29, 2016	Dec 3, 2016	1 AOP 108: Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat)
585	584: Inhibition, sodium channel	585: Decreased, Sodium conductance 1	Nov 29, 2016	Dec 3, 2016	3 AOPs 91: Sodium channel inhibition leading to reduced survival 93: sodium channel inhibition leading to increased predation 94: Sodium channel inhibition leading to congenital malformations
590	584: Inhibition, sodium channel	444: Increased, Atrioventricular block and bradycardia	Nov 29, 2016	Dec 3, 2016	None
1242	584: Inhibition, sodium channel	1176: Decreased, sodium conductance 2	Nov 29, 2016	Dec 3, 2016	1 AOP 197: Sodium channel (Nav1.1) inhibition leading to population decline
3414	584: Inhibition, sodium channel	698: Altered, Action Potential	Nov 21, 2024	Nov 21, 2024	1 AOP 553: Inhibition of Voltage-gated sodium channels (Na⁺ channels) leading to heart failure
867	845: Inhibition, UROD	844: Oxidation, Uroporphyrinogen	Nov 29, 2016	Nov 29, 2016	None
1070	845: Inhibition, UROD	846: Accumulation, Highly carboxylated porphyrins	Nov 29, 2016	May 30, 2018	1 AOP 131: Aryl hydrocarbon receptor activation leading to uroporphyria
335	305: Inhibition, VegfR2	28: Reduction, Angiogenesis	Nov 29, 2016	Jul 20, 2022	1 AOP 43: Disruption of VEGFR Signaling Leading to Developmental Defects
1382	1294: Inhibition, Wnt pathway	1295: Defect of Embryogenesis	Feb 15, 2017	Feb 15, 2017	1 AOP 210: Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building
3331	2255: Activation of the innate immune response	272: Activation/Proliferation, T-cells	Aug 13, 2024	Aug 13, 2024	None

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