AOP-Wiki

API

All KERs

Showing 1 to 25 of 3129 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

1927	1648: β-catenin activation	1649: Snail, Zeb, Twist activation	May 29, 2019	May 29, 2019	None
1924	1645: Wnt ligand stimulation	1646: Frizzled activation	May 29, 2019	May 29, 2019	None
1145	1107: Weakened, Colony	563: Death/Failure, Colony	Nov 29, 2016	Dec 3, 2016	13 AOPs 77: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1 87: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure 88: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste 89: Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure 79: Nicotinic acetylcholine receptor activation contributes to impaired hive thermoregulation and leads to colony loss/failure 178: Nicotinic acetylcholine receptor activation contributes to mitochondrial dysfunction and leads to colony loss/failure 179: Varroa mite infestation increases virus levels leading to colony loss/failure 180: Varroa mite infestation contributes to abnormal foraging leading to colony loss/failure 181: Weather event contributes to colony loss/failure 182: Weather event contributes abnormal foraging leading to colony loss/failure 183: Nosema infection increases energetic demands leading to colony loss/failure 184: Nosema infection causes abnormal role change that leads to colony loss/failure 185: Queen egg-laying decrease leads to colony loss/failure
2757	2062: Weak, Procuticle protection	2063: Decrease, New cuticle secretion	Aug 28, 2022	Aug 28, 2022	1 AOP 467: Knickkopf leading to mortality
1639	1465: Weak collagen matrix	1466: Notochord malformation	Aug 3, 2017	Aug 3, 2017	1 AOP 242: Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity
2693	2032: Viable offspring, decreased	360: Decrease, Population growth rate	Jul 18, 2022	Jul 18, 2022	None
3028	2178: Vascular barrier disruption	2161: Increase, Vascular disrupting effects	Aug 21, 2023	Aug 21, 2023	1 AOP 511: The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects
2084	1762: cell injury	795: Increase, Regenerative cell proliferation (urothelial cells)	Apr 21, 2020	Apr 21, 2020	1 AOP 335: AOP for urothelial carcinogenesis due to chemical cytotoxicity by mitochondrial impairment
3583	2344: Upregulation, gadd45ba	2345: Activation, MAPK	Aug 16, 2025	Aug 16, 2025	1 AOP 591: DBDPE-induced DNA damage increase in liver leading to Non-alcoholic fatty liver disease via liver steatosis and inhibition of regeneration
3584	2344: Upregulation, gadd45ba	2346: Downregulation, PCNA	Aug 16, 2025	Aug 16, 2025	1 AOP 591: DBDPE-induced DNA damage increase in liver leading to Non-alcoholic fatty liver disease via liver steatosis and inhibition of regeneration
699	695: Upregulated, Spindle assembly checkpoint protein Mad2-oocyte	696: Increased, Chromosome misseggregation	Nov 29, 2016	Dec 3, 2016	1 AOP 103: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint
1372	1285: Up Regulation, Unsaturated fatty acid	1289: Perturbation of cholesterol	Feb 15, 2017	Feb 15, 2017	1 AOP 209: Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP
303	276: Up Regulation, TGFbeta1 expression	68: Increase, Collagen accumulation	Nov 29, 2016	Dec 3, 2016	None
304	276: Up Regulation, TGFbeta1 expression	265: Increase, HSC activation	Nov 29, 2016	Nov 29, 2016	None
1371	1284: Up Regulation, SREBF2	1285: Up Regulation, Unsaturated fatty acid	Feb 15, 2017	Feb 15, 2017	1 AOP 209: Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP
493	462: Up Regulation, SCD-1	454: Increased, Triglyceride formation	Nov 29, 2016	Dec 3, 2016	2 AOPs 58: NR1I3 (CAR) suppression leading to hepatic steatosis 60: NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis
1657	462: Up Regulation, SCD-1	291: Accumulation, Triglyceride	Aug 31, 2017	Aug 31, 2017	1 AOP 57: AhR activation leading to hepatic steatosis
507	466: Up Regulation, LDLR (low density lipoprotein receptor)	467: Increased, LDL uptake	Nov 29, 2016	Dec 3, 2016	1 AOP 57: AhR activation leading to hepatic steatosis
492	463: Up Regulation, FAS	458: Increased, De Novo FA synthesis	Nov 29, 2016	Dec 3, 2016	1 AOP 58: NR1I3 (CAR) suppression leading to hepatic steatosis
104	84: Up Regulation, CYP1B1	3: Reduction, 17beta-estradiol synthesis by ovarian granulosa cells	Nov 29, 2016	Dec 3, 2016	None
96	80: Up Regulation, CYP1A1	209: Peptide Oxidation	Nov 29, 2016	Dec 3, 2016	None
66	54: Up Regulation, CD36	115: Increase, FA influx	Nov 29, 2016	Mar 27, 2024	2 AOPs 34: LXR activation leading to hepatic steatosis 517: Pregnane X Receptor (PXR) activation leads to liver steatosis
501	54: Up Regulation, CD36	465: Increased, FA Influx	Nov 29, 2016	Dec 3, 2016	3 AOPs 57: AhR activation leading to hepatic steatosis 60: NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis 58: NR1I3 (CAR) suppression leading to hepatic steatosis
2262	54: Up Regulation, CD36	460: Increased, Fatty acid uptake	Jan 15, 2021	Jan 15, 2021	None
517	470: Up Regulation, Acetyl-CoA carboxylase-1 (ACC-1)	458: Increased, De Novo FA synthesis	Nov 29, 2016	Dec 3, 2016	1 AOP 58: NR1I3 (CAR) suppression leading to hepatic steatosis

Key Event Relationships (KERs)

All KERs