AOP-Wiki

API

All KERs

Showing 2751 to 2775 of 3129 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

338	310: Alteration, Wnt pathway	240: Feminisation or incomplete development, Primary and accessory male sex organs	Nov 29, 2016	Dec 3, 2016	1 AOP 19: Androgen receptor antagonism leading to adverse effects in the male foetus (mammals)
3094	1060: Alteration, lipid metabolism	1513: General Apoptosis	Oct 18, 2023	Oct 19, 2023	1 AOP 513: Reactive Oxygen (ROS) formation leads to cancer via Peroxisome proliferation-activated receptor (PPAR) pathway
269	244: Alkylation, Protein	55: Cell injury/death	Nov 29, 2016	Nov 29, 2016	1 AOP 38: Protein Alkylation leading to Liver Fibrosis
271	244: Alkylation, Protein	209: Peptide Oxidation	Nov 29, 2016	Dec 3, 2016	None
3135	244: Alkylation, Protein	177: Increase, Mitochondrial dysfunction	Feb 28, 2024	Feb 28, 2024	1 AOP 258: Renal protein alkylation leading to kidney toxicity
23	97: Alkylation, DNA	336: Increase, Heritable mutations in offspring	Nov 29, 2016	Nov 29, 2016	1 AOP 15: Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations
24	97: Alkylation, DNA	155: Inadequate DNA repair	Nov 29, 2016	Dec 10, 2019	3 AOPs 15: Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations 139: Alkylation of DNA leading to cancer 1 322: Alkylation of DNA leading to reduced sperm count
25	97: Alkylation, DNA	185: Increase, Mutations	Nov 29, 2016	Nov 29, 2016	2 AOPs 15: Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations 139: Alkylation of DNA leading to cancer 1
901	97: Alkylation, DNA	885: Increase, Cancer	Nov 29, 2016	Dec 3, 2016	1 AOP 139: Alkylation of DNA leading to cancer 1
3771	97: Alkylation, DNA	1757: Reduce, Sperm count	Apr 7, 2026	Apr 7, 2026	None
2441	1907: ASL Height, Decreased	1908: CBF, Decreased	Jul 19, 2021	Sep 28, 2021	1 AOP 424: Oxidative stress Leading to Decreased Lung Function via CFTR dysfunction
2444	1907: ASL Height, Decreased	1910: Mucus Viscosity, Increased	Jul 19, 2021	Aug 2, 2021	None
2681	2013: Airway remodeling	2008: Chronic obstructive pulmonary disease	Jun 17, 2022	Jun 17, 2022	1 AOP 452: Adverse outcome pathway of PM-induced respiratory toxicity
1838	1586: Airway epithelial injury	149: Increase, Inflammation	Jan 30, 2019	Jan 30, 2019	1 AOP 280: α-diketone-induced bronchiolitis obliterans
3109	2201: RAR agonism	2202: Altered expression of cell cycle genes	Jan 14, 2024	Apr 18, 2024	2 AOPs 520: Retinoic acid receptor agonism during neurodevelopment leading to impaired learning and memory 523: Retinoic acid receptor agonism during neurodevelopment leading to microcephaly
3113	2201: RAR agonism	2203: Decreased proliferation of cortical NPCs	Jan 14, 2024	Feb 14, 2024	2 AOPs 520: Retinoic acid receptor agonism during neurodevelopment leading to impaired learning and memory 523: Retinoic acid receptor agonism during neurodevelopment leading to microcephaly
3114	2201: RAR agonism	341: Impairment, Learning and memory	Jan 14, 2024	Jan 14, 2024	1 AOP 520: Retinoic acid receptor agonism during neurodevelopment leading to impaired learning and memory
3128	2201: RAR agonism	2211: Microcephalus	Feb 2, 2024	Feb 2, 2024	None
3144	2201: RAR agonism	1978: Microcephaly	Mar 13, 2024	Mar 13, 2024	1 AOP 523: Retinoic acid receptor agonism during neurodevelopment leading to microcephaly
126	111: Agonism, Estrogen receptor	363: Altered, Reproductive behaviour	Nov 29, 2016	Dec 3, 2016	1 AOP 29: Estrogen receptor agonism leading to reproductive dysfunction
127	111: Agonism, Estrogen receptor	364: Impaired development of, Reproductive organs	Nov 29, 2016	Dec 3, 2016	1 AOP 29: Estrogen receptor agonism leading to reproductive dysfunction
128	111: Agonism, Estrogen receptor	307: Increase, Vitellogenin synthesis in liver	Nov 29, 2016	Jun 24, 2024	3 AOPs 29: Estrogen receptor agonism leading to reproductive dysfunction 536: Estrogen receptor agonism leading to reduced survival and population growth due to renal failure 537: Estrogen receptor agonism leads to reduced fecundity via increased vitellogenin in the liver
3525	111: Agonism, Estrogen receptor	749: Decreased, Progesterone from corpus luteum	Apr 17, 2025	Apr 17, 2025	1 AOP 112: Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat)
3528	111: Agonism, Estrogen receptor	1187: Increased, ER binding to DNA (classical pathway)	Apr 28, 2025	Apr 28, 2025	1 AOP 200: Estrogen receptor activation leading to breast cancer
3529	111: Agonism, Estrogen receptor	1188: Increased, ER binding to T.F. to DNA (non-classical pathway)	Apr 28, 2025	Apr 28, 2025	1 AOP 200: Estrogen receptor activation leading to breast cancer

Key Event Relationships (KERs)

All KERs