Key Event Relationships (KERs)

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Showing 351 to 375 of 3129 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
1211 1146: premature, Spawning 1164: Increased, Population Nov 29, 2016 Dec 3, 2016 None
1222 1146: premature, Spawning 1141: Decreased, Reproductive Success Nov 29, 2016 Dec 3, 2016 None
2607 1979: Premature differentiation 1978: Microcephaly Mar 21, 2022 Mar 21, 2022 None
3107 1979: Premature differentiation 2200: decline, neural progenitor cells Jan 10, 2024 Jan 10, 2024
2458 1857: Platelet-neutrophil interactions, Increased 1916: Thromboinflammation, Increased Aug 4, 2021 Aug 4, 2021
2456 1914: Platelet activation, Increased 1857: Platelet-neutrophil interactions, Increased Aug 4, 2021 Aug 4, 2021
3438 2294: Plasma E2, increased 2251: Increased E2 availability Nov 22, 2024 Nov 22, 2024
3718 2294: Plasma E2, increased 2306: Persistent vaginal cornification Jan 29, 2026 Feb 3, 2026
3746 2294: Plasma E2, increased 2413: Increased, uterine weight Mar 13, 2026 Mar 13, 2026
3761 2294: Plasma E2, increased 2415: Precocious puberty Mar 26, 2026 Mar 26, 2026
3769 2294: Plasma E2, increased 1075: prolonged, estrus cycle Apr 6, 2026 Apr 6, 2026
2151 1794: Pin-1 activation 1795: TGFbeta expression Jul 9, 2020 Jul 9, 2020
3427 2288: Phosphodiesterase (PDE) 2284: Intracellular cAMP Nov 22, 2024 Nov 22, 2024 None
3445 2288: Phosphodiesterase (PDE) 693: Increased, cyclic adenosine monophosphate Nov 26, 2024 Nov 26, 2024
1377 1289: Perturbation of cholesterol 1291: Hepatotoxicity Feb 15, 2017 Feb 15, 2017
1125 1086: persistent, cytotoxicity (pleura or peritoneum) 1087: Increased, inflammation Nov 29, 2016 Dec 3, 2016
3261 1086: persistent, cytotoxicity (pleura or peritoneum) 1392: Increase, Oxidative Stress Jul 3, 2024 Jul 3, 2024
395 228: demethylation, PPARg promoter 408: reduction in ovarian granulosa cells, Aromatase (Cyp19a1) Nov 29, 2016 Dec 3, 2016 None
411 228: demethylation, PPARg promoter 54: Up Regulation, CD36 Nov 29, 2016 Nov 29, 2016
487 228: demethylation, PPARg promoter 457: Activation, SREBF1 Nov 29, 2016 Dec 3, 2016
1402 228: demethylation, PPARg promoter 1301: Activation, SREBP-1 Apr 12, 2017 Apr 12, 2017 None
1424 228: demethylation, PPARg promoter 116: Activation, FAS Apr 13, 2017 Apr 13, 2017 None
1608 228: demethylation, PPARg promoter 1028: Activation of specific nuclear receptors, PPAR-gamma activation Jul 24, 2017 Jul 24, 2017
1659 228: demethylation, PPARg promoter 465: Increased, FA Influx Aug 31, 2017 Aug 31, 2017
2988 228: demethylation, PPARg promoter 2165: Activation of PPAR Aug 20, 2023 Aug 20, 2023