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All KERs

Showing 501 to 525 of 3129 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

1803	1557: Reduced neural crest cell migration	1558: Reduced collagen production	Dec 20, 2018	Dec 20, 2018	1 AOP 274: Histone deacetylase inhibition leads to impeded craniofacial development
2563	1557: Reduced neural crest cell migration	1970: Transposition of the great arteries	Feb 8, 2022	Feb 15, 2022	1 AOP 436: Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries
1789	1548: Necrotic Tissue	1549: Liver Injury	Dec 19, 2018	Mar 7, 2019	2 AOPs 273: Mitochondrial complex inhibition leading to liver injury 278: IKK complex inhibition leading to liver injury
3754	1263: Necrosis	2009: Activation, inflammation pathway	Mar 25, 2026	Mar 25, 2026	1 AOP 638: Co-exposure to microplastics and cadmium leading to progression from NAFLD to liver tumorigenesis
3148	1259: narcosis	177: Increase, Mitochondrial dysfunction	Mar 13, 2024	Mar 13, 2024	1 AOP 205: AOP from chemical insult to cell death
324	294: N/A, Unknown	57: Proliferation, Cell proliferation in the absence of cytotoxicity	Nov 29, 2016	Dec 3, 2016	1 AOP 1: Uncharacterized liver damage leading to hepatocellular carcinoma
751	294: N/A, Unknown	759: Increased, Kidney Failure	Nov 29, 2016	Dec 3, 2016	1 AOP 33: Kidney toxicity induced by activation of 5HT2C
650	634: N/A, sedation	635: Decreased, locomotion	Nov 29, 2016	Dec 3, 2016	1 AOP 99: Histamine (H2) receptor antagonism leading to reduced survival
242	213: N/A, Parent compound is converted to the reactive metabolite and forms free radicals leadin	21: Altered regulation, Alpha hemoglobin	Nov 29, 2016	Dec 3, 2016	1 AOP 31: Oxidation of iron in hemoglobin leading to hematotoxicity
243	213: N/A, Parent compound is converted to the reactive metabolite and forms free radicals leadin	118: Formation, Formation of hemoglobin adducts	Nov 29, 2016	Dec 3, 2016	1 AOP 31: Oxidation of iron in hemoglobin leading to hematotoxicity
245	213: N/A, Parent compound is converted to the reactive metabolite and forms free radicals leadin	250: Damaging, Red blood cells; hemolysis	Nov 29, 2016	Dec 3, 2016	1 AOP 31: Oxidation of iron in hemoglobin leading to hematotoxicity
3323	213: N/A, Parent compound is converted to the reactive metabolite and forms free radicals leadin	1392: Increase, Oxidative Stress	Jul 24, 2024	Jul 24, 2024	1 AOP 31: Oxidation of iron in hemoglobin leading to hematotoxicity
207	352: N/A, Neurodegeneration	188: Neuroinflammation	Nov 29, 2016	Jun 13, 2018	2 AOPs 48: Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. 12: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging
368	352: N/A, Neurodegeneration	386: Neuronal network function, Decreased	Nov 29, 2016	Dec 3, 2016	None
647	352: N/A, Neurodegeneration	618: Decreased, Neuronal network function in adult brain	Nov 29, 2016	Nov 29, 2016	2 AOPs 48: Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. 450: Inhibition of AChE and activation of CYP2E1 leading to sensory axonal peripheral neuropathy and mortality
1069	352: N/A, Neurodegeneration	341: Impairment, Learning and memory	Nov 29, 2016	Apr 11, 2024	2 AOPs 12: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging 500: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis
2287	352: N/A, Neurodegeneration	1841: Encephalitis	Feb 23, 2021	Feb 23, 2021	2 AOPs 374: Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on brain cells (neuronal and non-neuronal) leads to neuroinflammation resulting in encephalitis 471: Neuron defect induced early behavioral change
3070	352: N/A, Neurodegeneration	388: Overactivation, NMDARs	Oct 17, 2023	Oct 17, 2023	1 AOP 471: Neuron defect induced early behavioral change
3075	352: N/A, Neurodegeneration	637: impaired, Learning and memory	Oct 17, 2023	Oct 17, 2023	1 AOP 471: Neuron defect induced early behavioral change
3081	352: N/A, Neurodegeneration	1348: Increase, seizure	Oct 17, 2023	Oct 17, 2023	1 AOP 471: Neuron defect induced early behavioral change
182	173: N/A, Methemoglobinemia, decreased hemoglobin, hematocrit, red blood cell number	321: N/A, Cyanosis occurs	Nov 29, 2016	Dec 3, 2016	1 AOP 31: Oxidation of iron in hemoglobin leading to hematotoxicity
2889	345: N/A, Liver Steatosis	55: Cell injury/death	Apr 13, 2023	Apr 13, 2023	None
168	158: N/A, Interferences with SH-/selen-proteins	130: Depletion, GSH	Nov 29, 2016	Dec 3, 2016	None
593	590: N/A, hypoxia	591: Increased, amputations	Nov 29, 2016	Dec 3, 2016	1 AOP 94: Sodium channel inhibition leading to congenital malformations
3307	590: N/A, hypoxia	1376: Increase, angiogenesis	Jul 18, 2024	Jul 18, 2024	None

Key Event Relationships (KERs)

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