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All KERs

Showing 876 to 900 of 3129 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

813	813: Increased, Serum creatinine	818: Occurrence, Cytoplasmic vacuolization (Renal tubule)	Nov 29, 2016	Dec 3, 2016	1 AOP 128: Kidney dysfunction by decreased thyroid hormone
814	813: Increased, Serum creatinine	823: Occurrence, Cystic dilatation (renal tubule)	Nov 29, 2016	Dec 3, 2016	1 AOP 128: Kidney dysfunction by decreased thyroid hormone
816	813: Increased, Serum creatinine	824: Occurrence, Cytoplasmic vacuolization (podocyte)	Nov 29, 2016	Dec 3, 2016	1 AOP 128: Kidney dysfunction by decreased thyroid hormone
1524	1397: Increased, serotonin transporter activity	1398: Increased, intracellular serotonin	Jun 1, 2017	Jun 1, 2017	3 AOPs 223: Serotonin transporter activation to seizure 224: Serotonin transporter activation to depression 225: Serotonin transporter activation to agitation
1528	1397: Increased, serotonin transporter activity	1347: Decreased, extracellular serotonin	Jun 1, 2017	Jun 1, 2017	3 AOPs 223: Serotonin transporter activation to seizure 224: Serotonin transporter activation to depression 225: Serotonin transporter activation to agitation
636	620: Increased, serotonin (5-HT) 1	621: Increase, cilia movement	Nov 29, 2016	Dec 3, 2016	None
640	620: Increased, serotonin (5-HT) 1	625: Increased, muscular waves in foot	Nov 29, 2016	Dec 3, 2016	None
1172	620: Increased, serotonin (5-HT) 1	1142: Increased, valve movement	Nov 29, 2016	Dec 3, 2016	None
1186	620: Increased, serotonin (5-HT) 1	1145: Decreased, gametogenesis	Nov 29, 2016	Dec 3, 2016	None
1189	620: Increased, serotonin (5-HT) 1	622: Increased, locomotion	Nov 29, 2016	Dec 3, 2016	None
1192	620: Increased, serotonin (5-HT) 1	1147: increased or inappropriate, mantel display	Nov 29, 2016	Dec 3, 2016	None
644	626: Increased, serotonin (5-HT)	627: Decreased, anxiety	Nov 29, 2016	Dec 3, 2016	1 AOP 98: 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to decreased shelter seeking and increased predation
1207	626: Increased, serotonin (5-HT)	1160: Increased, mantel display	Nov 29, 2016	Dec 3, 2016	None
1209	626: Increased, serotonin (5-HT)	1162: Increased, cilia movement	Nov 29, 2016	Dec 3, 2016	None
1212	626: Increased, serotonin (5-HT)	1161: Increased, oocyte maturation	Nov 29, 2016	Dec 3, 2016	1 AOP 195: 5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase
1327	626: Increased, serotonin (5-HT)	1142: Increased, valve movement	Jan 17, 2017	Jan 17, 2017	4 AOPs 195: 5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase 97: 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline 204: 5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase 203: 5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline
1332	626: Increased, serotonin (5-HT)	625: Increased, muscular waves in foot	Jan 30, 2017	Jan 30, 2017	1 AOP 97: 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline
1333	626: Increased, serotonin (5-HT)	621: Increase, cilia movement	Jan 30, 2017	Jan 30, 2017	3 AOPs 204: 5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase 195: 5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase 203: 5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline
1336	626: Increased, serotonin (5-HT)	1256: increased mantel display	Jan 30, 2017	Jan 30, 2017	2 AOPs 204: 5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase 203: 5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline
1550	1344: Increased, seizure	1363: Increased, epilepsy	Jun 2, 2017	Jun 2, 2017	2 AOPs 230: presynaptic neuron 1 activation to epilepsy 231: presynaptic neuron 2 repression to epilepsy
1703	1496: Increased proinflammatory mediators	1497: Recruitment of inflammatory cells	Jan 5, 2018	May 18, 2023	5 AOPs 173: Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis 392: Decreased fibrinolysis and activated bradykinin system leading to hyperinflammation 409: Frustrated phagocytosis leads to malignant mesothelioma 451: Interaction with lung resident cell membrane components leads to lung cancer 468: Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death)
2053	1496: Increased proinflammatory mediators	1438: Increased transcription of genes encoding acute phase proteins	Mar 1, 2020	Jan 20, 2025	1 AOP 237: Substance interaction with lung resident cell membrane components leading to atherosclerosis
2061	1496: Increased proinflammatory mediators	1750: Increased inflammatory immune responses	Mar 10, 2020	Mar 10, 2020	1 AOP 320: Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality
2301	1496: Increased proinflammatory mediators	1849: Impaired gustatory nerve	Mar 28, 2021	Mar 28, 2021	None
2307	1496: Increased proinflammatory mediators	68: Increase, Collagen accumulation	Mar 30, 2021	Mar 30, 2021	2 AOPs 382: Angiotensin II type 1 receptor (AT1R) agonism leading to lung fibrosis 319: Binding to ACE2 leading to lung fibrosis

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