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Showing 1126 to 1150 of 3129 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

2498	1847: SARS-CoV-2 production	1939: Viral infection, proliferated	Oct 24, 2021	Jun 29, 2024	1 AOP 430: Binding of SARS-CoV-2 to ACE2 leads to viral infection proliferation
2545	1847: SARS-CoV-2 production	1870: Sustentacular cells, decrease	Jan 5, 2022	Jan 5, 2022	1 AOP 394: SARS-CoV-2 infection of olfactory epithelium leading to impaired olfactory function (short-term anosmia)
2546	1847: SARS-CoV-2 production	1931: Disruption of the intestinal barrier	Jan 5, 2022	Jun 14, 2022	1 AOP 422: Binding of SARS-CoV-2 to ACE2 in enterocytes leads to intestinal barrier disruption
1770	1226: Respiratory irritability	1223: Increased Airway Hyper-responsiveness,Cough, Dyspnea	Sep 24, 2018	Sep 24, 2018	1 AOP 196: Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation
1719	1493: Increased pro-inflammatory mediators	55: Cell injury/death	Feb 1, 2018	Feb 12, 2018	1 AOP 17: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory
1764	1493: Increased pro-inflammatory mediators	265: Increase, HSC activation	Aug 2, 2018	Aug 2, 2018	1 AOP 38: Protein Alkylation leading to Liver Fibrosis
1777	1493: Increased pro-inflammatory mediators	1494: Leukocyte recruitment/activation	Nov 12, 2018	Nov 12, 2018	3 AOPs 144: Endocytic lysosomal uptake leading to liver fibrosis 293: Increased DNA damage leading to increased risk of breast cancer 294: Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer
1902	1493: Increased pro-inflammatory mediators	1193: N/A, Breast Cancer	May 7, 2019	May 10, 2019	2 AOPs 294: Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer 293: Increased DNA damage leading to increased risk of breast cancer
1903	1493: Increased pro-inflammatory mediators	1632: Increase in RONS	May 7, 2019	May 9, 2019	2 AOPs 293: Increased DNA damage leading to increased risk of breast cancer 294: Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer
1908	1493: Increased pro-inflammatory mediators	1182: Increase, Cell Proliferation (Epithelial Cells)	May 10, 2019	May 10, 2019	2 AOPs 294: Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer 293: Increased DNA damage leading to increased risk of breast cancer
2777	1493: Increased pro-inflammatory mediators	2068: Increase, Endothelial Dysfunction	Sep 28, 2022	Aug 26, 2024	1 AOP 470: Deposition of energy leads to abnormal vascular remodeling
2902	2132: Increased cytokine expression	1633: Increase in inflammation	May 4, 2023	May 4, 2023	1 AOP 493: ERa inactivation alters AT expansion and functions and leads to insulin resistance and metabolically unhealthy obesity
3781	1889: premature meiosis, male germ cells	1890: Germ cell loss, male	Apr 24, 2026	Apr 24, 2026	1 AOP 400: Inhibition of CYP26B1 activity in fetal testis leading to reduced fertility
1954	1662: plasma homocysteine increases	1663: brain Homocysteine level increases	Jun 14, 2019	Jun 14, 2019	None
3471	2303: Plasma estradiol/progesterone ratio, increase	2251: Increased E2 availability	Jan 10, 2025	Jan 14, 2025	1 AOP 566: Decreased, GnRH pulsatility/release leading to estradiol availability, increased via impaired ovulation
3473	2303: Plasma estradiol/progesterone ratio, increase	2306: Persistent vaginal cornification	Jan 13, 2025	Jan 14, 2025	1 AOP 566: Decreased, GnRH pulsatility/release leading to estradiol availability, increased via impaired ovulation
1193	1147: increased or inappropriate, mantel display	1141: Decreased, Reproductive Success	Nov 29, 2016	Dec 3, 2016	None
1219	1147: increased or inappropriate, mantel display	1143: Depletion, energy reserves	Nov 29, 2016	Dec 3, 2016	None
1220	1147: increased or inappropriate, mantel display	1167: induced, parturition	Nov 29, 2016	Dec 3, 2016	None
3535	2324: Dysregulation of Treg/Th17 cell ratio	2325: Decreased number of LT CD8+ cells	May 16, 2025	May 16, 2025	None
3538	2324: Dysregulation of Treg/Th17 cell ratio	2326: CTL cytotoxicity	May 22, 2025	May 22, 2025	1 AOP 578: AhR activation leading to cancer progression via immunosuppression
1584	1435: Increased NKA	1223: Increased Airway Hyper-responsiveness,Cough, Dyspnea	Jun 23, 2017	Jun 23, 2017	None
1585	1435: Increased NKA	1225: Leukocyte infiltration	Jun 23, 2017	Jun 23, 2017	None
1773	1435: Increased NKA	1226: Respiratory irritability	Sep 24, 2018	Sep 24, 2018	1 AOP 196: Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation
2430	1897: MyD88 activation	1172: Increased activation, Nuclear factor kappa B (NF-kB)	Jul 8, 2021	Jul 8, 2021	1 AOP 377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)

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