Key Event Relationships (KERs)

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Showing 2551 to 2575 of 3102 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
1782 1543: Mitochondrial Complex IV inhibition 1545: Decrease in mitochondrial oxidative phosphorylation Dec 19, 2018 Mar 7, 2019
3555 1543: Mitochondrial Complex IV inhibition 177: Increase, Mitochondrial dysfunction Aug 1, 2025 Aug 1, 2025
1783 1544: Mitochondrial Complex V inhibition 1545: Decrease in mitochondrial oxidative phosphorylation Dec 19, 2018 Mar 7, 2019
2193 1816: Mitochondrial dysfunction EMPTY 1817: Apoptotic cell death Nov 2, 2020 Nov 2, 2020 None
2195 1816: Mitochondrial dysfunction EMPTY 1815: Increase, ER stress Nov 2, 2020 Nov 2, 2020 None
2499 1816: Mitochondrial dysfunction EMPTY 1392: Increase, Oxidative Stress Oct 26, 2021 Oct 26, 2021
2932 1816: Mitochondrial dysfunction EMPTY 2144: Impaired insulin signaling May 25, 2023 May 25, 2023 None
3043 1816: Mitochondrial dysfunction EMPTY 1585: Proteasomal dysfunction Sep 14, 2023 Sep 14, 2023 None
188 178: Mitochondrial electron transport chain, disrupted 40: Mitochondrial ATP production, decreased Nov 29, 2016 Dec 3, 2016
3493 178: Mitochondrial electron transport chain, disrupted 1115: Increase, ROS Feb 25, 2025 Feb 25, 2025
1942 1547: Mitochondrial Injury 889: Proteostasis, impaired Jun 7, 2019 Jun 7, 2019 None
2715 1547: Mitochondrial Injury 1825: Increase, Cell death Jul 25, 2022 Jul 25, 2022 None
3049 1547: Mitochondrial Injury 1812: Increase, Cyt c release Sep 14, 2023 Sep 14, 2023
3749 1195: modulation, Extracellular Matrix Composition 870: Increase, Cell Proliferation Mar 25, 2026 Mar 25, 2026
3757 1195: modulation, Extracellular Matrix Composition 344: Increase, Liver fibrosis Mar 25, 2026 Mar 25, 2026
603 598: modulation, sodium channel 599: prolonged, Depolarization of neuronal membrane Nov 29, 2016 Dec 3, 2016
802 801: modulation, Unknown 802: Increased, HIF-1 alpha transcription Nov 29, 2016 Dec 3, 2016
2448 1912: Motile Cilia Number/Length, Decreased 1908: CBF, Decreased Jul 23, 2021 Sep 28, 2021
1563 1425: Mu Opioid Receptor Agonism 1426: Release of G Proteins Jun 8, 2017 Jun 8, 2017
2443 1909: MCC, Decreased 1250: Decreased lung function Jul 19, 2021 Mar 24, 2023
2445 1910: Mucus Viscosity, Increased 1908: CBF, Decreased Jul 19, 2021 Aug 2, 2021 None
2446 1910: Mucus Viscosity, Increased 1909: MCC, Decreased Jul 19, 2021 Aug 2, 2021 None
757 764: N/A, Ataxia, paralysis, or hyperactivity 351: Increased Mortality Nov 29, 2016 Dec 3, 2016
88 75: N/A, Covalent binding to protein, possibly lysine residue 151: Activation, Inflammatory cytokines, chemokines, cytoprotective gene pathways Nov 29, 2016 Sep 24, 2020 None
1700 75: N/A, Covalent binding to protein, possibly lysine residue 398: Activation, Dendritic Cells Dec 7, 2017 Sep 24, 2020 None