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Showing 2801 to 2825 of 3130 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

1112	1075: prolonged, estrus cycle	1077: Increased, prolactin exposure	Nov 29, 2016	Dec 3, 2016	1 AOP 168: GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat.
3770	1075: prolonged, estrus cycle	406: decreased, Fertility	Apr 6, 2026	Apr 6, 2026	1 AOP 640: Activation, estrogen receptor alpha leads to decreased fertility via prolonged estrus cycle
2829	1053: Promotion, ovarian adenomas	2092: Promotion, Ovarian Cancer	Jan 13, 2023	Mar 11, 2023	1 AOP 440: Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia
2830	1054: Promotion, ovarian granular cell tumors	2092: Promotion, Ovarian Cancer	Jan 13, 2023	Jan 13, 2023	None
1104	1066: Promotion, SIX1 positive progenitor cells in endometrium	1067: Proliferation/Clonal Expansion, aberrant basal-type cells	Nov 29, 2016	Dec 3, 2016	None
3605	1066: Promotion, SIX1 positive progenitor cells in endometrium	1560: Cell differentiation, altered	Aug 21, 2025	Aug 28, 2025	None
3626	1066: Promotion, SIX1 positive progenitor cells in endometrium	1068: Endometrial squamous metaplasia, Increase	Sep 3, 2025	Sep 18, 2025	1 AOP 167: Early-life estrogen receptor agonism leading to endometrial adenosquamous carcinoma via promotion of sine oculis homeobox 1 progenitor cells
3627	1066: Promotion, SIX1 positive progenitor cells in endometrium	772: Increase, Hyperplasia (glandular epithelial cells of endometrium)	Sep 3, 2025	Sep 18, 2025	1 AOP 167: Early-life estrogen receptor agonism leading to endometrial adenosquamous carcinoma via promotion of sine oculis homeobox 1 progenitor cells
2912	2136: prostatic intraepithelial neoplasia	2135: Prostate cancer	May 11, 2023	May 11, 2023	1 AOP 495: Androgen receptor activation leading to prostate cancer
1837	1585: Proteasomal dysfunction	1586: Airway epithelial injury	Jan 30, 2019	Jan 30, 2019	1 AOP 280: α-diketone-induced bronchiolitis obliterans
3044	1585: Proteasomal dysfunction	1605: Accumulation, misfolded proteins	Sep 14, 2023	Sep 14, 2023	1 AOP 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
1729	1509: Protein Adduct Formation	1512: Unfolded Protein Response	Apr 4, 2018	Apr 5, 2018	1 AOP 260: CYP2E1 activation and formation of protein adducts leading to neurodegeneration
3246	2029: GPER activation	389: Increased, Intracellular Calcium overload	Jun 19, 2024	Jun 19, 2024	1 AOP 535: Binding and activation of GPER leading to learning and memory impairments
3247	2029: GPER activation	2233: Decreased, ERαβ heterodimers	Jun 19, 2024	Jun 19, 2024	1 AOP 535: Binding and activation of GPER leading to learning and memory impairments
905	889: Proteostasis, impaired	890: Degeneration of dopaminergic neurons of the nigrostriatal pathway	Nov 29, 2016	Oct 3, 2025	2 AOPs 3: Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits 593: Redox cycling of a chemical by mitochondria leads to degeneration of nigrostriatal dopaminergic neurons
1943	889: Proteostasis, impaired	55: Cell injury/death	Jun 7, 2019	Jun 7, 2019	1 AOP 273: Mitochondrial complex inhibition leading to liver injury
3579	889: Proteostasis, impaired	2343: Cuproptosis, increased	Aug 13, 2025	Aug 13, 2025	1 AOP 590: Increase of intracellular copper leading to cuproptosis via interference with energy metabolism
2679	2010: Pulmonary inflammation	2008: Chronic obstructive pulmonary disease	Jun 17, 2022	Jun 17, 2022	1 AOP 452: Adverse outcome pathway of PM-induced respiratory toxicity
3755	1967: Pyroptosis	2009: Activation, inflammation pathway	Mar 25, 2026	Mar 25, 2026	1 AOP 638: Co-exposure to microplastics and cadmium leading to progression from NAFLD to liver tumorigenesis
1848	1593: Radical generation	1597: DNA photo-adducts	Feb 4, 2019	Feb 4, 2019	None
1849	1593: Radical generation	1598: Protein photo-adducts	Feb 4, 2019	Feb 4, 2019	None
3629	2362: Redox cycling	2363: Mito ROS dysfunction	Sep 7, 2025	Oct 3, 2025	1 AOP 593: Redox cycling of a chemical by mitochondria leads to degeneration of nigrostriatal dopaminergic neurons
1447	1329: Reduce expression, BDNF	1330: Decreased, neuroplasticity	Apr 14, 2017	Apr 14, 2017	4 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 222: Mental stress to agitation 225: Serotonin transporter activation to agitation 224: Serotonin transporter activation to depression
3783	1757: Reduce, Sperm count	406: decreased, Fertility	Apr 24, 2026	Apr 24, 2026	1 AOP 400: Inhibition of CYP26B1 activity in fetal testis leading to reduced fertility
3702	2398: Reduced antibody production	2397: Diminished vaccine response	Dec 3, 2025	Dec 3, 2025	1 AOP 618: PPARgamma activation leads to a diminished vaccine response

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