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All KERs

Showing 1226 to 1250 of 3102 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

1514	1393: Hepatocytotoxicity	1394: Sustained proliferation	May 30, 2017	Jun 19, 2021	1 AOP 220: Cyp2E1 Activation Leading to Liver Cancer
1517	1393: Hepatocytotoxicity	1395: Liver Cancer	May 30, 2017	May 1, 2020	1 AOP 220: Cyp2E1 Activation Leading to Liver Cancer
2535	1957: hERG channel biogenesis interference	1958: Direct hERG channel blockage	Dec 13, 2021	Dec 13, 2021	None
2536	1957: hERG channel biogenesis interference	1959: Induction of hERG trafficking defects	Dec 13, 2021	Dec 13, 2021	None
2850	2099: hERG channel blockade	2100: Inhibition of rapid delayed rectifying potassium current	Jan 29, 2023	Jan 29, 2023	1 AOP 433: hERG channel blockade leading to sudden cardiac death
749	757: Hippocampal anatomy, Altered	758: Hippocampal Physiology, Altered	Nov 29, 2016	Jul 25, 2024	5 AOPs 42: Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 134: Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 300: Thyroid Receptor Antagonism and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 8: Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 442: Binding to voltage gate sodium channels during development leads to cognitive impairment
747	756: Hippocampal gene expression, Altered	757: Hippocampal anatomy, Altered	Nov 29, 2016	Aug 11, 2018	4 AOPs 42: Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 134: Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 300: Thyroid Receptor Antagonism and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 8: Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
2886	756: Hippocampal gene expression, Altered	758: Hippocampal Physiology, Altered	Apr 12, 2023	Apr 12, 2023	2 AOPs 458: AhR activation in the liver leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals 459: AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals
748	758: Hippocampal Physiology, Altered	402: Cognitive function, decreased	Nov 29, 2016	Jul 26, 2024	6 AOPs 42: Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 134: Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 300: Thyroid Receptor Antagonism and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 458: AhR activation in the liver leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals 459: AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals 442: Binding to voltage gate sodium channels during development leads to cognitive impairment
2484	758: Hippocampal Physiology, Altered	319: Loss, Cochlear function	Sep 14, 2021	Sep 14, 2021	1 AOP 8: Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
2864	758: Hippocampal Physiology, Altered	341: Impairment, Learning and memory	Apr 3, 2023	Apr 3, 2023	1 AOP 490: Co-activation of IP3R and RyR leads to reduced IQ and increased socio-economic burden through non-cholinergic mechanisms
1710	1503: Histone acetylation, increase	1504: p21 (CDKN1A) expression, increase	Jan 21, 2018	Jul 25, 2018	None
1806	1503: Histone acetylation, increase	1239: Altered, Gene Expression	Dec 20, 2018	Dec 20, 2018	1 AOP 275: Histone deacetylase inhibition leads to neural tube defects
1997	1503: Histone acetylation, increase	1505: Cell cycle, disrupted	Nov 11, 2019	Jul 1, 2021	1 AOP 212: Histone deacetylase inhibition leading to testicular atrophy
1709	1502: Histone deacetylase inhibition	1503: Histone acetylation, increase	Jan 21, 2018	Aug 5, 2021	2 AOPs 212: Histone deacetylase inhibition leading to testicular atrophy 275: Histone deacetylase inhibition leads to neural tube defects
1714	1502: Histone deacetylase inhibition	1504: p21 (CDKN1A) expression, increase	Jan 21, 2018	Jul 25, 2018	None
1715	1502: Histone deacetylase inhibition	1505: Cell cycle, disrupted	Jan 21, 2018	Jul 28, 2021	1 AOP 212: Histone deacetylase inhibition leading to testicular atrophy
1716	1502: Histone deacetylase inhibition	1262: Apoptosis	Jan 21, 2018	Jul 1, 2021	1 AOP 212: Histone deacetylase inhibition leading to testicular atrophy
1717	1502: Histone deacetylase inhibition	1506: Testicular atrophy	Jan 21, 2018	Jul 28, 2021	1 AOP 212: Histone deacetylase inhibition leading to testicular atrophy
1802	1502: Histone deacetylase inhibition	1557: Reduced neural crest cell migration	Dec 20, 2018	Dec 20, 2018	1 AOP 274: Histone deacetylase inhibition leads to impeded craniofacial development
1805	1502: Histone deacetylase inhibition	1558: Reduced collagen production	Dec 20, 2018	Dec 20, 2018	1 AOP 274: Histone deacetylase inhibition leads to impeded craniofacial development
2010	1502: Histone deacetylase inhibition	1515: Spermatocyte depletion	Dec 11, 2019	Jul 1, 2021	1 AOP 212: Histone deacetylase inhibition leading to testicular atrophy
2699	1502: Histone deacetylase inhibition	1561: Neural tube defects	Jul 19, 2022	Jul 19, 2022	1 AOP 449: Ceramide synthase inhibition leading to neural tube defects
3328	2252: Formation of HLA-DQ2/8-gluten complexes	272: Activation/Proliferation, T-cells	Aug 13, 2024	Aug 13, 2024	None
3338	2252: Formation of HLA-DQ2/8-gluten complexes	2260: Activation of gluten-reactive CD4+ T cells	Sep 13, 2024	Sep 13, 2024	None

Key Event Relationships (KERs)

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