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Showing 2001 to 2025 of 3130 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

2777	1493: Increased pro-inflammatory mediators	2068: Increase, Endothelial Dysfunction	Sep 28, 2022	Aug 26, 2024	1 AOP 470: Deposition of energy leads to abnormal vascular remodeling
1770	1226: Respiratory irritability	1223: Increased Airway Hyper-responsiveness,Cough, Dyspnea	Sep 24, 2018	Sep 24, 2018	1 AOP 196: Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation
2291	1847: SARS-CoV-2 production	1392: Increase, Oxidative Stress	Mar 25, 2021	Mar 25, 2021	None
2351	1847: SARS-CoV-2 production	1848: TLR Activation/Dysregulation	Apr 16, 2021	Apr 16, 2021	1 AOP 320: Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality
2358	1847: SARS-CoV-2 production	1869: Diminished Protective Response to ROS	Apr 20, 2021	Sep 26, 2023	2 AOPs 379: Binding to ACE2 leading to thrombosis and disseminated intravascular coagulation 406: SARS-CoV-2 infection leading to hyperinflammation
2488	1847: SARS-CoV-2 production	1825: Increase, Cell death	Oct 19, 2021	Oct 19, 2021	1 AOP 468: Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death)
2498	1847: SARS-CoV-2 production	1939: Viral infection, proliferated	Oct 24, 2021	Jun 29, 2024	1 AOP 430: Binding of SARS-CoV-2 to ACE2 leads to viral infection proliferation
2545	1847: SARS-CoV-2 production	1870: Sustentacular cells, decrease	Jan 5, 2022	Jan 5, 2022	1 AOP 394: SARS-CoV-2 infection of olfactory epithelium leading to impaired olfactory function (short-term anosmia)
2546	1847: SARS-CoV-2 production	1931: Disruption of the intestinal barrier	Jan 5, 2022	Jun 14, 2022	1 AOP 422: Binding of SARS-CoV-2 to ACE2 in enterocytes leads to intestinal barrier disruption
2329	1855: Increased Sodium-sensitive hypertension	1603: Chronic kidney disease	Apr 10, 2021	Apr 10, 2021	1 AOP 384: Hyperactivation of ACE/Ang-II/AT1R axis leading to chronic kidney disease
2698	2033: Increased S1-P	1502: Histone deacetylase inhibition	Jul 19, 2022	Jul 19, 2022	1 AOP 449: Ceramide synthase inhibition leading to neural tube defects
1592	1441: Systemic cholesterol increased	1442: Foam cell formation	Jun 29, 2017	Jun 29, 2017	None
3418	2285: the delayed and early afterdepolarizations	1106: Occurrence, cardiac arrhythmia	Nov 21, 2024	Nov 21, 2024	1 AOP 554: β-adrenergic receptor agonists leading to arrhythmias.
3412	2283: Early premature depolarizations	1929: Increased incidence of cardiovascular morbidity and mortality	Nov 21, 2024	Nov 21, 2024	1 AOP 519: Cardiac ion channels blockade leading to increased incidence of cardiovascular morbidity and mortality
3421	2283: Early premature depolarizations	1535: Heart failure	Nov 21, 2024	Nov 21, 2024	1 AOP 555: Inhibition, Ether-a-go-go (ERG) Voltage-Gated Potassium Channel leading to heart failure
3409	2281: uncoordinated cardiac contraction	1929: Increased incidence of cardiovascular morbidity and mortality	Nov 20, 2024	Nov 20, 2024	None
3447	2281: uncoordinated cardiac contraction	1535: Heart failure	Nov 27, 2024	Nov 27, 2024	1 AOP 552: Inhibiton of L-Type Calcium Channels leading to heart failure via QT interval prolongation and Torsades de Pointes (TdP)
2315	1858: Increased viral transcription and replication	1496: Increased proinflammatory mediators	Apr 9, 2021	Apr 9, 2021	None
2316	1858: Increased viral transcription and replication	1848: TLR Activation/Dysregulation	Apr 9, 2021	Apr 9, 2021	None
1445	1326: Increased, 5-HT3	1344: Increased, seizure	Apr 14, 2017	Apr 14, 2017	1 AOP 214: Network of SSRIs (selective serotonin reuptake inhibitors)
707	708: Increased, Accumulation of alpha2u microglobulin (proximal tubular epithelium)	709: Increase, Cytotoxicity (renal tubular cell)	Nov 29, 2016	Dec 3, 2016	1 AOP 105: Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat)
1706	1499: Activation of Th2 cells	1500: Increased cellular proliferation and differentiation	Jan 5, 2018	May 18, 2023	1 AOP 173: Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis
1073	1029: Increased, adipogenesis	1032: Increased, secretion of local growth factors	Nov 29, 2016	Dec 3, 2016	1 AOP 163: PPARgamma activation leading to sarcomas in rats, mice, and hamsters
568	574: Increased, Appetite and hunger	560: Abnormal, Foraging activity and behavior	Nov 29, 2016	Dec 3, 2016	1 AOP 81: Increased metabolic stress contributes to abnormal foraging and leads to colony loss/failure
607	602: Increased, Ataxia, paralysis, or hyperactivity	351: Increased Mortality	Nov 29, 2016	Dec 3, 2016	1 AOP 96: Axonal sodium channel modulation leading to acute mortality

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