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Showing 2001 to 2025 of 3102 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

707	708: Increased, Accumulation of alpha2u microglobulin (proximal tubular epithelium)	709: Increase, Cytotoxicity (renal tubular cell)	Nov 29, 2016	Dec 3, 2016	1 AOP 105: Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat)
1706	1499: Activation of Th2 cells	1500: Increased cellular proliferation and differentiation	Jan 5, 2018	May 18, 2023	1 AOP 173: Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis
1073	1029: Increased, adipogenesis	1032: Increased, secretion of local growth factors	Nov 29, 2016	Dec 3, 2016	1 AOP 163: PPARgamma activation leading to sarcomas in rats, mice, and hamsters
568	574: Increased, Appetite and hunger	560: Abnormal, Foraging activity and behavior	Nov 29, 2016	Dec 3, 2016	1 AOP 81: Increased metabolic stress contributes to abnormal foraging and leads to colony loss/failure
607	602: Increased, Ataxia, paralysis, or hyperactivity	351: Increased Mortality	Nov 29, 2016	Dec 3, 2016	1 AOP 96: Axonal sodium channel modulation leading to acute mortality
3673	602: Increased, Ataxia, paralysis, or hyperactivity	1005: Reduced, Swimming performance	Oct 20, 2025	Oct 20, 2025	1 AOP 611: Behavioral abnormalities due to increased expression of dopamine transporter and receptor-related genes
432	444: Increased, Atrioventricular block and bradycardia	351: Increased Mortality	Nov 29, 2016	Nov 29, 2016	None
591	444: Increased, Atrioventricular block and bradycardia	445: Respiratory distress/arrest	Nov 29, 2016	Dec 3, 2016	1 AOP 94: Sodium channel inhibition leading to congenital malformations
2871	2124: increased, Bax	55: Cell injury/death	Apr 4, 2023	Apr 4, 2023	1 AOP 490: Co-activation of IP3R and RyR leads to reduced IQ and increased socio-economic burden through non-cholinergic mechanisms
2874	2124: increased, Bax	1825: Increase, Cell death	Apr 4, 2023	Apr 4, 2023	None
3467	2124: increased, Bax	1262: Apoptosis	Jan 4, 2025	May 29, 2025	1 AOP 563: Aryl hydrocarbon Receptor (AHR) activation causes Premature Ovarian Insufficiency via Bax mediated apoptosis
706	714: Increased, Binding of chemicals to 2u (serum)	708: Increased, Accumulation of alpha2u microglobulin (proximal tubular epithelium)	Nov 29, 2016	Dec 3, 2016	1 AOP 105: Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat)
1135	1098: Increased, blood potassium concentration	1100: Occurrence, cardiac arrthymia	Nov 29, 2016	Dec 3, 2016	None
1140	1098: Increased, blood potassium concentration	1106: Occurrence, cardiac arrhythmia	Nov 29, 2016	Dec 3, 2016	3 AOPs 177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality 138: Organic anion transporter (OAT1) inhibition leading to renal failure and mortality 186: unknown MIE leading to renal failure and mortality
3403	1098: Increased, blood potassium concentration	1983: Disruption in action potential generation	Nov 20, 2024	Nov 20, 2024	1 AOP 551: Increased Muscarinic M2 Receptor leading to Arrhythmia
1132	1096: Increased, blood uric acid concentration	1102: Occurrence, tophi (urate) deposition	Nov 29, 2016	Dec 3, 2016	2 AOPs 138: Organic anion transporter (OAT1) inhibition leading to renal failure and mortality 177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
3263	1096: Increased, blood uric acid concentration	1392: Increase, Oxidative Stress	Jul 3, 2024	Jul 3, 2024	2 AOPs 138: Organic anion transporter (OAT1) inhibition leading to renal failure and mortality 177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
3291	2238: Increased, Blood viscosity	2239: Increased, Cardiac stress	Jul 8, 2024	Dec 3, 2024	1 AOP 539: Decreased Sodium/Potassium ATPase activity leads to Heart failure
703	699: Increased, cardiac arrthymia	351: Increased Mortality	Nov 29, 2016	Dec 3, 2016	1 AOP 104: Altered ion channel activity leading impaired heart function
3292	2239: Increased, Cardiac stress	1535: Heart failure	Jul 8, 2024	Dec 3, 2024	1 AOP 539: Decreased Sodium/Potassium ATPase activity leads to Heart failure
885	863: Increased, Catabolism of Muscle Protein	864: Decreased, Body Weight	Nov 29, 2016	Jun 11, 2018	1 AOP 6: Antagonist binding to PPARα leading to body-weight loss
1130	1089: Increased, Cell Proliferation (mesothelium)	1090: Increased, mesotheliomas	Nov 29, 2016	Dec 3, 2016	1 AOP 171: Chronic cytotoxicity of the serous membrane leading to pleural/peritoneal mesotheliomas in the rat.
1099	1062: Increased, Cellular proliferation / hyperplasia of acinar cells	1063: Increased, Pancreatic acinar tumors	Nov 29, 2016	Dec 3, 2016	1 AOP 166: PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse
758	761: Increased, Chloride conductance	763: hyperpolarisation, neuron	Nov 29, 2016	Dec 3, 2016	1 AOP 113: Glutamate-gated chloride channel activation leading to acute mortality
1052	761: Increased, Chloride conductance	1015: Increased, Neuronal synaptic inhibition	Nov 29, 2016	Dec 3, 2016	2 AOPs 160: Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality 161: Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality

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