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Showing 2326 to 2350 of 3102 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

1520	1316: Inhibit, serotonin transporter activity	1317: Decreased, serotonin transporter activity	May 30, 2017	May 30, 2017	None
2707	2039: Inhibition, GABAAr	1527: Increase, Cell membrane depolarization	Jul 25, 2022	Jul 25, 2022	1 AOP 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
3595	2349: Inhibition of LDH activity	2350: Decreased, Glycolysis	Aug 16, 2025	Aug 16, 2025	1 AOP 592: DBDPE-induced DNA strand breaks and LDH activity inhibition leading to population growth rate decline via energy metabolism disrupt and apoptosis
2162	1799: Inhibition of 11β-HSD	1756: Decreased, 11KT	Jul 13, 2020	Jul 13, 2020	1 AOP 348: Inhibition of 11β-Hydroxysteroid Dehydrogenase leading to decreased population trajectory
1952	1660: betaine-homocysteine methyltransferase inhibition	1661: Homocysteine increases	Jun 14, 2019	Jun 14, 2019	None
2694	2023: Inhibition CerS	2024: Reduced complex sphingolipids	Jul 19, 2022	Jul 20, 2022	1 AOP 449: Ceramide synthase inhibition leading to neural tube defects
2697	2023: Inhibition CerS	2033: Increased S1-P	Jul 19, 2022	Jul 19, 2022	1 AOP 449: Ceramide synthase inhibition leading to neural tube defects
1949	1657: CBS inhibition	1661: Homocysteine increases	Jun 14, 2019	Jun 14, 2019	1 AOP 301: Inhibition of Cystathionine Beta synthase leading to impaired the early development of anterior-posterior axis
3433	2290: if	2291: Bradycardia	Nov 22, 2024	Nov 22, 2024	1 AOP 560: Inhibition of Funny current (If) leading to Arrhythmias
2402	1884: Inhibition of Fyna	1885: Inhibition of Plxna2	May 28, 2021	Dec 12, 2021	1 AOP 399: Inhibition of Fyna leading to increased mortality via decreased eye size (Microphthalmos)
2539	1960: Inhibition of Ikr	1961: Prolongation of Action Potential	Dec 13, 2021	Dec 13, 2021	None
2024	1715: Inhibition of JAK3	1716: STAT5 inhibition	Jan 5, 2020	Nov 3, 2021	1 AOP 315: Inhibition of JAK3 leading to impairment of T-Cell Dependent Antibody Response
1969	1672: Inhibition of LS function.	1673: Alveolar collapse	Jul 3, 2019	Jul 3, 2019	1 AOP 302: Lung surfactant function inhibition leading to decreased lung function
2255	1672: Inhibition of LS function.	1498: Loss of alveolar capillary membrane integrity	Jan 8, 2021	Jan 8, 2021	None
2256	1672: Inhibition of LS function.	1677: Reduced tidal volume	Jan 8, 2021	Jan 8, 2021	None
2370	1672: Inhibition of LS function.	1250: Decreased lung function	Apr 27, 2021	Apr 27, 2021	1 AOP 302: Lung surfactant function inhibition leading to decreased lung function
1637	1463: Inhibition of lysyl oxidase	1464: Reduction of collagen crosslinking	Aug 3, 2017	Aug 3, 2017	1 AOP 242: Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity
1951	1658: Methionine synthase	1661: Homocysteine increases	Jun 14, 2019	Jun 14, 2019	None
1950	1659: MTHFR inhibition	1661: Homocysteine increases	Jun 14, 2019	Jun 14, 2019	None
1673	1481: Inhibition, mitochondrial DNA polymerase gamma (Pol gamma)	1482: Depletion, mtDNA	Oct 25, 2017	Oct 25, 2017	1 AOP 256: Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity
1864	1604: Inhibition of N-linked glycosylation	1605: Accumulation, misfolded proteins	Mar 6, 2019	Mar 6, 2019	1 AOP 285: Inhibition of N-linked glycosylation leads to liver injury
1569	1429: Inhibition of Ca Channels	1430: Inhibition of neurotransmitter release	Jun 23, 2017	Jun 23, 2017	2 AOPs 234: Mu Opioid Receptor Agonism leading to Analgesia via Ca Channel Inhibition 236: Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via Ca Channel Inhibition
3422	2286: Na⁺/K⁺-ATPase	1535: Heart failure	Nov 21, 2024	Nov 21, 2024	None
3423	2286: Na⁺/K⁺-ATPase	1321: Increased, intracellular sodium (Na+)	Nov 21, 2024	Nov 21, 2024	None
1570	1430: Inhibition of neurotransmitter release	1428: Analgesia	Jun 23, 2017	Jun 23, 2017	1 AOP 234: Mu Opioid Receptor Agonism leading to Analgesia via Ca Channel Inhibition

Key Event Relationships (KERs)

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