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Showing 2376 to 2400 of 3102 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

2350	36: Inhibition, Aromatase	1791: Increased, Male Biased Sex Ratio	Apr 13, 2021	Jan 10, 2023	1 AOP 346: Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation
3394	36: Inhibition, Aromatase	2277: Inhibition, plasma aromatase activity	Nov 16, 2024	Nov 16, 2024	1 AOP 549: Aromatase inhibition leads to reproductive toxicity (including growth and developmental toxicity) in adult female zebrafish
3532	36: Inhibition, Aromatase	219: Reduction, Plasma 17beta-estradiol concentrations	Apr 29, 2025	Apr 29, 2025	None
3395	2277: Inhibition, plasma aromatase activity	219: Reduction, Plasma 17beta-estradiol concentrations	Nov 16, 2024	Nov 16, 2024	1 AOP 549: Aromatase inhibition leads to reproductive toxicity (including growth and developmental toxicity) in adult female zebrafish
927	41: Inhibition, Bile Salt Export Pump (ABCB11)	214: Bile accumulation, Pathological condition	Nov 29, 2016	Dec 3, 2016	1 AOP 27: Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11)
61	51: Inhibition, Ca++ ATPase	50: Increase, Ca++ (intracellular)	Nov 29, 2016	Dec 3, 2016	1 AOP 26: Calcium-mediated neuronal ROS production and energy imbalance
1015	980: Inhibition, Calcineurin Activity	978: Activation, Suppression of NFAT activation and hindrance of nuclear localization	Nov 29, 2016	Dec 3, 2016	None
1254	980: Inhibition, Calcineurin Activity	1202: Suppression, IL-2 and IL-4 production	Nov 29, 2016	Dec 3, 2016	None
1508	980: Inhibition, Calcineurin Activity	979: Interference, nuclear localization of NFAT	May 19, 2017	Jun 27, 2021	1 AOP 154: Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response
1742	1522: Inhibition, CHS-1	1523: Decrease, Cuticular chitin content	May 24, 2018	Feb 17, 2021	2 AOPs 360: Chitin synthase 1 inhibition leading to mortality 606: Ecdysone receptor antagonism leading to mortality via inhibition of chitin synthase 1
2170	1806: Inhibition, Chitinase	996: Decrease, Digestion of old cuticle	Oct 21, 2020	Oct 21, 2020	1 AOP 358: Chitinase inhibition leading to mortality
2172	1807: Inhibition, Chitobiase	996: Decrease, Digestion of old cuticle	Oct 21, 2020	Oct 21, 2020	1 AOP 359: Chitobiase inhibition leading to mortality
1137	1103: Inhibition, Cyclooxygenase 1 activity	1104: Decreased, Prostaglandin F2alpha concentration, plasma	Nov 29, 2016	Dec 3, 2016	1 AOP 177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
95	79: Inhibition, Cyclooxygenase activity	243: Reduction, Prostaglandin E2 concentration	Nov 29, 2016	Dec 3, 2016	1 AOP 28: Cyclooxygenase inhibition leading reproductive failure
670	79: Inhibition, Cyclooxygenase activity	672: Reduced, Prostaglandin F2alpha synthesis, ovary	Nov 29, 2016	Dec 3, 2016	1 AOP 100: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior
681	79: Inhibition, Cyclooxygenase activity	681: Decreased, Prostaglandin F2alpha synthesis, ovary	Nov 29, 2016	Dec 3, 2016	1 AOP 101: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release
686	79: Inhibition, Cyclooxygenase activity	685: Reduced, Prostaglandins, ovary	Nov 29, 2016	Dec 3, 2016	1 AOP 63: Cyclooxygenase inhibition leading to reproductive dysfunction
689	79: Inhibition, Cyclooxygenase activity	687: Reduced, Prostaglandin E2 concentration, hypothalamus	Nov 29, 2016	Dec 3, 2016	2 AOPs 102: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition 103: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint
3503	1840: Inhibition, cytochrome oxidase	1825: Increase, Cell death	Mar 5, 2025	Mar 18, 2025	3 AOPs 368: Cytochrome oxidase inhibition leading to increased nasal lesions 573: Inhibition, cytochrome oxidase leads to Increased, pulmonary edema 574: Inhibition, cytochrome oxidase leads to Loss of olfactory function
1878	1609: Inhibition of Cyp17A1 activity	1610: Reduction, DHEA	Apr 10, 2019	Apr 8, 2025	1 AOP 288: Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals)
1879	1609: Inhibition of Cyp17A1 activity	1611: Reduction, androstenedione	Apr 10, 2019	Apr 8, 2025	1 AOP 288: Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals)
1037	1009: Inhibition, Deiodinase 1	1003: Decreased, Triiodothyronine (T3)	Nov 29, 2016	Nov 19, 2025	2 AOPs 157: Deiodinase 1 inhibition leading to increased mortality via reduced posterior swim bladder inflation 158: Deiodinase 1 inhibition leading to increased mortality via reduced anterior swim bladder inflation
1044	1009: Inhibition, Deiodinase 1	1004: Reduced, Posterior swim bladder inflation	Nov 29, 2016	Oct 10, 2022	1 AOP 157: Deiodinase 1 inhibition leading to increased mortality via reduced posterior swim bladder inflation
1045	1009: Inhibition, Deiodinase 1	1007: Reduced, Anterior swim bladder inflation	Nov 29, 2016	Mar 8, 2019	None
1198	1009: Inhibition, Deiodinase 1	1116: Decreased, Triiodothyronine (T3) in tissues	Nov 29, 2016	Dec 3, 2016	1 AOP 189: Type I iodothyronine deiodinase (DIO1) inhibition leading to altered amphibian metamorphosis

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