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Showing 2426 to 2450 of 3188 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

1569	1429: Inhibition of Ca Channels	1430: Inhibition of neurotransmitter release	Jun 23, 2017	Jun 23, 2017	2 AOPs 234: Mu Opioid Receptor Agonism leading to Analgesia via Ca Channel Inhibition 236: Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via Ca Channel Inhibition
3422	2286: Na⁺/K⁺-ATPase	1535: Heart failure	Nov 21, 2024	Nov 21, 2024	None
3423	2286: Na⁺/K⁺-ATPase	1321: Increased, intracellular sodium (Na+)	Nov 21, 2024	Nov 21, 2024	None
1570	1430: Inhibition of neurotransmitter release	1428: Analgesia	Jun 23, 2017	Jun 23, 2017	1 AOP 234: Mu Opioid Receptor Agonism leading to Analgesia via Ca Channel Inhibition
1573	1430: Inhibition of neurotransmitter release	1432: Anti-depressant Activity	Jun 23, 2017	Jun 23, 2017	1 AOP 236: Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via Ca Channel Inhibition
3536	2311: PI3K-Akt pathway	1115: Increase, ROS	May 22, 2025	May 22, 2025	1 AOP 569: Decreased DNA methylation of FAM50B/PTCHD3 leading to IQ loss of children via PI3K-Akt pathway
2403	1885: Inhibition of Plxna2	1886: Overexpression of rasl11b	May 28, 2021	Dec 12, 2021	1 AOP 399: Inhibition of Fyna leading to increased mortality via decreased eye size (Microphthalmos)
2851	2100: Inhibition of rapid delayed rectifying potassium current	1961: Prolongation of Action Potential	Jan 29, 2023	Jan 29, 2023	1 AOP 433: hERG channel blockade leading to sudden cardiac death
2974	2155: SULT1E1 inhibition	1973: Increased, estrogens	Jul 28, 2023	Jul 28, 2023	None
3390	2155: SULT1E1 inhibition	2251: Increased E2 availability	Nov 15, 2024	Feb 21, 2025	1 AOP 504: SULT1E1 inhibition leading to uterine adenocarcinoma via increased estrogen availability at target organ level
1891	1627: tyrosinase	1628: Reduction of L-Dopaquinone	May 3, 2019	May 3, 2019	1 AOP 292: Inhibition of tyrosinase leads to decreased population in fish
3852	2452: inhbition to MTP	2453: reduced lipid efflux	Sep 9, 2026	Sep 9, 2026	1 AOP 653: Inhibition to Microsomal Triglyceride Transfer Protein Leads to Steatosis
3016	2174: Inhibition VEGF/VEGFR pathway	2161: Increase, Vascular disrupting effects	Aug 21, 2023	Aug 21, 2023	None
3025	2174: Inhibition VEGF/VEGFR pathway	1928: increased，Vascular endothelial dysfunction	Aug 21, 2023	Aug 21, 2023	1 AOP 511: The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects
775	766: Inhibition, 4-hydroxyphenyl-pyruvate dioxygenase (HPPD) enzyme	775: Increased, Plasma tyrosine	Nov 29, 2016	Dec 3, 2016	1 AOP 114: HPPD inhibition leading to corneal papillomas and carcinomas (in rat)
635	619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)	620: Increased, serotonin (5-HT) 1	Nov 29, 2016	Dec 3, 2016	None
643	619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)	626: Increased, serotonin (5-HT)	Nov 29, 2016	Dec 3, 2016	5 AOPs 98: 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to decreased shelter seeking and increased predation 195: 5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase 97: 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline 204: 5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase 203: 5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline
1208	619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)	1162: Increased, cilia movement	Nov 29, 2016	Dec 3, 2016	None
1316	619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)	625: Increased, muscular waves in foot	Jan 13, 2017	Jan 13, 2017	1 AOP 97: 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline
1317	619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)	1142: Increased, valve movement	Jan 13, 2017	Jan 13, 2017	3 AOPs 97: 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline 203: 5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline 204: 5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase
1318	619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)	621: Increase, cilia movement	Jan 13, 2017	Jan 13, 2017	3 AOPs 203: 5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline 204: 5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase 195: 5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase
1319	619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)	1256: increased mantel display	Jan 13, 2017	Jan 13, 2017	2 AOPs 203: 5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline 204: 5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase
1337	619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)	1161: Increased, oocyte maturation	Jan 30, 2017	Jan 30, 2017	1 AOP 195: 5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase
3474	619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)	1320: Increased, extracellular serotonin	Jan 14, 2025	Feb 13, 2025	1 AOP 568: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) leads to Inhibition, Feeding
1880	1617: Inhibition, 5α-reductase	1613: Decrease, DHT level	Apr 18, 2019	Mar 20, 2026	4 AOPs 289: Inhibition of 5α-reductase leading to decreased population growth rate via impaired fecundity in female fish 305: 5α-reductase inhibition leading to short anogenital distance (AGD) in male (mammalian) offspring 571: 5α-reductase inhibition leading to hypospadias in male (mammalian) offspring 576: 5α-reductase inhibition leading to increased nipple retention (NR) in male (rodent) offspring

Key Event Relationships (KERs)

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