AOP-Wiki

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All Key Events

Showing 701 to 725 of 1921 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1685	Anomalies, Congenital cardiac conotruncal Short Name	0	Individual	Aug 13, 2019	Aug 13, 2019	304: TBX1 inhibition leading to congenital cardiac conotruncal anomalies
1684	Abnormalities, Cardiac outflow tract formation Short Name	0	Organ	Aug 13, 2019	Aug 13, 2019	304: TBX1 inhibition leading to congenital cardiac conotruncal anomalies
1683	Impairment, Fourth pharyngeal arch development Short Name	0	Tissue	Aug 13, 2019	Aug 13, 2019	304: TBX1 inhibition leading to congenital cardiac conotruncal anomalies
1682	Disruption, Progenitor cells of second heart field Short Name	0	Cellular	Aug 13, 2019	Feb 15, 2022	2 AOPs 304: TBX1 inhibition leading to congenital cardiac conotruncal anomalies 436: Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries
1681	Disruption, Neural crest cell migration Short Name Disruption, Neural crest cell migration	0	Cellular	Aug 13, 2019	Aug 13, 2019	304: TBX1 inhibition leading to congenital cardiac conotruncal anomalies
1680	Inhibition, TBX1 Short Name Inhibition, TBX1	0	Molecular	Aug 13, 2019	Aug 13, 2019	304: TBX1 inhibition leading to congenital cardiac conotruncal anomalies
1679	Acute inhalation toxicity Short Name Acute inhalation toxicity	0	Individual	Jul 3, 2019	Jul 3, 2019	None
1678	Impaired oxygenation of the blood Short Name Impaired oxygenation of the blood	0	Organ	Jul 3, 2019	Jul 3, 2019	None
1677	Reduced tidal volume Short Name Reduced tidal volume	0	Organ	Jul 3, 2019	Feb 16, 2021	302: Lung surfactant function inhibition leading to decreased lung function
1676	Blood extravasation into the lungs Short Name Blood extravasation into the lungs	0	Organ	Jul 3, 2019	Jul 3, 2019	None
1675	Loss of barrier function Short Name Loss of barrier function	0	Tissue	Jul 3, 2019	Jul 3, 2019	None
1674	Alveolar reopening Short Name Alveolar reopening	0	Tissue	Jul 3, 2019	Jul 3, 2019	None
1673	Alveolar collapse Short Name Alveolar collapse	0	Cellular	Jul 3, 2019	Oct 27, 2021	302: Lung surfactant function inhibition leading to decreased lung function
1672	Inhibition of lung surfactant function Short Name Inhibition of LS function.	0	Molecular	Jul 3, 2019	Oct 27, 2021	302: Lung surfactant function inhibition leading to decreased lung function
1671	Substance - lung surfactant interaction Short Name Substance - LS interaction	0	Molecular	Jul 3, 2019	Jul 3, 2019	None
1670	Lung cancer Short Name Lung cancer	2	Organ	Jul 3, 2019	Aug 13, 2019	5 AOPs 303: Frustrated phagocytosis-induced lung cancer 416: Aryl hydrocarbon receptor activation leading to lung cancer through IL-6 toxicity pathway 417: Aryl hydrocarbon receptor activation leading to lung cancer through AHR-ARNT toxicity pathway 420: Aryl hydrocarbon receptor activation leading to lung cancer through sustained NRF2 toxicity pathway 451: Interaction with lung resident cell membrane components leads to lung cancer
1669	Increased, DNA damage and mutation Short Name Increased, DNA damage and mutation	5	Cellular	Jul 3, 2019	Aug 13, 2019	6 AOPs 303: Frustrated phagocytosis-induced lung cancer 409: Frustrated phagocytosis leads to malignant mesothelioma 416: Aryl hydrocarbon receptor activation leading to lung cancer through IL-6 toxicity pathway 417: Aryl hydrocarbon receptor activation leading to lung cancer through AHR-ARNT toxicity pathway 443: DNA damage and mutations leading to Metastatic Breast Cancer 451: Interaction with lung resident cell membrane components leads to lung cancer
1668	Frustrated phagocytosis Short Name Frustrated phagocytosis	1	Cellular	Jul 3, 2019	Sep 16, 2022	2 AOPs 303: Frustrated phagocytosis-induced lung cancer 409: Frustrated phagocytosis leads to malignant mesothelioma
1667	Impaired,anterior-posterior axis development Short Name anterior-posterior axis development	0	Individual	Jul 3, 2019	Jul 3, 2019	301: Inhibition of Cystathionine Beta synthase leading to impaired the early development of anterior-posterior axis
1666	Induced, dysfunction of microcirculation Short Name dysfunction of microcirculation	0	Organ	Jul 3, 2019	Jul 3, 2019	2 AOPs 301: Inhibition of Cystathionine Beta synthase leading to impaired the early development of anterior-posterior axis 426: SARS-CoV-2 spike protein binding to ACE2 receptors expressed on pericytes leads to endothelial cell dysfunction, microvascular injury and myocardial infarction.
1665	Increased, Plasma HCY level Short Name Plasma HCY level	0	Tissue	Jul 3, 2019	Jul 3, 2019	301: Inhibition of Cystathionine Beta synthase leading to impaired the early development of anterior-posterior axis
1664	Induce Neuronal dysfunctions Short Name Neuronal dysfunctions induction	0	Individual	Jun 14, 2019	Jun 14, 2019	None
1663	Increased brain Homocysteine level Short Name brain Homocysteine level increases	0	Organ	Jun 14, 2019	Jun 14, 2019	None
1662	Increased plasma Homocysteine level Short Name plasma homocysteine increases	0	Tissue	Jun 14, 2019	Jun 14, 2019	None
1661	Increased Homocysteine level Short Name Homocysteine increases	0	Cellular	Jun 14, 2019	Jun 14, 2019	301: Inhibition of Cystathionine Beta synthase leading to impaired the early development of anterior-posterior axis