AOP-Wiki

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All Key Events

Showing 726 to 750 of 1921 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1660	Inhibition of betaine-homocysteine methyltransferase Short Name	0	Molecular	Jun 14, 2019	Jun 14, 2019	None
1659	Inhibition of Methylenetetrahydrofolate reductase Short Name MTHFR inhibition	0	Molecular	Jun 14, 2019	Jun 14, 2019	None
1658	Inhibition of Methionine synthase Short Name Methionine synthase	0	Molecular	Jun 14, 2019	Jun 14, 2019	None
1657	Inhibition of cystathionine beta-synthase Short Name CBS inhibition	0	Molecular	Jun 14, 2019	Jun 14, 2019	301: Inhibition of Cystathionine Beta synthase leading to impaired the early development of anterior-posterior axis
1656	Antagonism, Thyroid Receptor Short Name TR Antagnoism	0	Molecular	Jun 8, 2019	Apr 27, 2026	4 AOPs 300: Thyroid Receptor Antagonism and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 485: Thyroid hormone antagonism leading to impaired oligodendrocyte maturation during development and subsequent decreased cognition 525: Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory 610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function
1655	Binding of inhibitor to mitochondrial complex V Short Name	0	Molecular	Jun 7, 2019	Jun 7, 2019	273: Mitochondrial complex inhibition leading to liver injury
1654	Binding of inhibitor to mitochondrial complex IV Short Name	0	Molecular	Jun 7, 2019	Jun 7, 2019	273: Mitochondrial complex inhibition leading to liver injury
1653	Binding of inhibitor to mitochondrial complex III Short Name	0	Molecular	Jun 7, 2019	Jun 7, 2019	273: Mitochondrial complex inhibition leading to liver injury
1652	Increase, S-adenosylmethionine depletion Short Name Increase, SAM depletion	0	Molecular	May 30, 2019	May 30, 2019	None
1651	Treatment-resistant gastric cancer Short Name Resistant gastric cancer	1	Tissue	May 29, 2019	Jun 12, 2025	298: Increase in reactive oxygen species (ROS) leading to human treatment-resistant gastric cancer
1649	Snail, Zeb, Twist activation Short Name Snail, Zeb, Twist activation	0	Molecular	May 29, 2019	May 29, 2019	None
1648	β-catenin activation Short Name β-catenin activation	0	Molecular	May 29, 2019	May 29, 2019	None
1647	GSK3beta inactivation Short Name GSK3beta inactivation	0	Molecular	May 29, 2019	Oct 5, 2021	410: GSK3beta inactivation leading to increased mortality via defects in developing inner ear
1646	Frizzled activation Short Name Frizzled activation	0	Molecular	May 29, 2019	May 29, 2019	None
1645	Wnt ligand stimulation Short Name Wnt ligand stimulation	0	Molecular	May 28, 2019	May 29, 2019	None
1644	Impaired Ab production Short Name Impaired Ab production	0	Cellular	May 23, 2019	Jun 25, 2019	None
1643	Altered, Visual function Short Name Altered, Visual function	1	Organ	May 22, 2019	Jul 8, 2022	5 AOPs 297: Inhibition of retinaldehyde dehydrogenase leads to population decline 399: Inhibition of Fyna leading to increased mortality via decreased eye size (Microphthalmos) 363: Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure 364: Thyroperoxidase inhibition leading to altered visual function via decreased eye size 365: Thyroperoxidase inhibition leading to altered visual function via altered photoreceptor patterning
1642	Decreased plasma RA level Short Name plasma retinoic acid	0	Tissue	May 22, 2019	Nov 3, 2025	297: Inhibition of retinaldehyde dehydrogenase leads to population decline
1641	Decreased retinoic acid (RA) synthesis Short Name retinoic acid	0	Cellular	May 22, 2019	May 22, 2019	297: Inhibition of retinaldehyde dehydrogenase leads to population decline
1640	Altered, Photoreceptor patterning Short Name Altered, Photoreceptor patterning	0	Cellular	May 22, 2019	Jun 16, 2021	2 AOPs 297: Inhibition of retinaldehyde dehydrogenase leads to population decline 365: Thyroperoxidase inhibition leading to altered visual function via altered photoreceptor patterning
1639	Plasma RA level decreased Short Name Plasma RA	0	Tissue	May 22, 2019	May 22, 2019	None
1638	Retinoic acid (RA) synthesis decreased Short Name RA	0	Cellular	May 22, 2019	May 22, 2019	None
1637	Retinaldehyde dehydrogenase inhibition Short Name Retinaldehyde dehydrogenase	0	Molecular	May 22, 2019	May 22, 2019	297: Inhibition of retinaldehyde dehydrogenase leads to population decline
1636	Increase, Chromosomal aberrations Short Name Increase, Chromosomal aberrations	1	Cellular	May 19, 2019	Mar 8, 2024	3 AOPs 296: Oxidative DNA damage leading to chromosomal aberrations and mutations 272: Deposition of energy leading to lung cancer 478: Deposition of energy leading to occurrence of cataracts
1635	Increase, DNA strand breaks Short Name Increase, DNA strand breaks	1	Molecular	May 19, 2019	Dec 17, 2024	10 AOPs 296: Oxidative DNA damage leading to chromosomal aberrations and mutations 272: Deposition of energy leading to lung cancer 322: Alkylation of DNA leading to reduced sperm count 216: Deposition of energy leading to population decline via DNA strand breaks and follicular atresia 238: Deposition of energy leading to population decline via DNA strand breaks and oocyte apoptosis 478: Deposition of energy leading to occurrence of cataracts 483: Deposition of Energy Leading to Learning and Memory Impairment 470: Deposition of energy leads to abnormal vascular remodeling 592: DBDPE-induced DNA strand breaks and LDH activity inhibition leading to population growth rate decline via energy metabolism disrupt and apoptosis 602: Excessive reactive oxygen species leading to growth inhibition via oxidative DNA damage