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All Key Events

Showing 1326 to 1350 of 1921 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1034	Increased, IGF-1 (mouse) Short Name Increased, IGF-1 (mouse)	1	Cellular	Nov 29, 2016	Sep 16, 2017	163: PPARgamma activation leading to sarcomas in rats, mice, and hamsters
1033	Increased, proliferation of mesenchymal cells Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	163: PPARgamma activation leading to sarcomas in rats, mice, and hamsters
1032	Increased, secretion of local growth factors Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	2 AOPs 163: PPARgamma activation leading to sarcomas in rats, mice, and hamsters 171: Chronic cytotoxicity of the serous membrane leading to pleural/peritoneal mesotheliomas in the rat.
1031	Increased, release of growth factors Short Name Increased, release of growth factors	0		Nov 29, 2016	Nov 29, 2016	None
1030	Increased, Short Name Increased,	0		Nov 29, 2016	Nov 29, 2016	None
1029	Increased, adipogenesis Short Name Increased, adipogenesis	1	Cellular	Nov 29, 2016	Sep 16, 2017	163: PPARgamma activation leading to sarcomas in rats, mice, and hamsters
1028	Activation of specific nuclear receptors, PPAR-gamma activation Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	3 AOPs 163: PPARgamma activation leading to sarcomas in rats, mice, and hamsters 72: Epigenetic modification of PPARG leading to adipogenesis 618: PPARgamma activation leads to a diminished vaccine response
1027	, Learning and memory, impairment Short Name , Learning and memory, impairment	0		Nov 29, 2016	Nov 29, 2016	None
1026	Increased Apoptosis, Adenomas/carcinomas (follicular cell) Short Name	2	Tissue	Nov 29, 2016	Sep 16, 2017	None
1025	Increased, Hyperplasia (follicular cells) Short Name	1	Tissue	Nov 29, 2016	Sep 16, 2017	None
1024	Increased, Hypertrophy and proliferation (follicular cell) Short Name	2	Cellular	Nov 29, 2016	Sep 16, 2017	None
1023	Increased, Thyroid-stimulating hormone (TSH) Short Name	1	Tissue	Nov 29, 2016	Sep 16, 2017	4 AOPs 162: Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse 190: Type II iodothyronine deiodinase (DIO2) inhibition leading to altered amphibian metamorphosis 110: Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse) 119: Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse)
1022	Decreased, serum T4/T3 Short Name Decreased, serum T4/T3	1	Tissue	Nov 29, 2016	Sep 16, 2017	None
1021	Increased, T4/T3 catabolism Short Name Increased, T4/T3 catabolism	1	Cellular	Nov 29, 2016	Sep 16, 2017	None
1020	Increased, induction of UDPGT's in liver Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	None
1019	Induction, pharyngeal muscle paralysis Short Name Induction, pharyngeal muscle paralysis	1	Tissue	Nov 29, 2016	Sep 16, 2017	161: Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality
1018	Activation, Glutamate-gated chloride channels Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	2 AOPs 161: Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality 471: Neuron defect induced early behavioral change
1017	Reduced, Feeding 2 Short Name Reduced, Feeding 2	0		Nov 29, 2016	Nov 29, 2016	None
1016	Inhibition, Feeding Short Name Inhibition, Feeding	1	Individual	Nov 29, 2016	Jan 14, 2025	4 AOPs 161: Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality 160: Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality 471: Neuron defect induced early behavioral change 568: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) leads to Inhibition, Feeding
1015	Increased, Neuronal synaptic inhibition Short Name Increased, Neuronal synaptic inhibition	1	Cellular	Nov 29, 2016	Sep 16, 2017	3 AOPs 161: Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality 160: Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality 471: Neuron defect induced early behavioral change
1014	Induction, Somatic muscle paralysis Short Name Induction, Somatic muscle paralysis	1	Tissue	Nov 29, 2016	Sep 16, 2017	2 AOPs 160: Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality 471: Neuron defect induced early behavioral change
1013	Inhibition, Motor neuron activity Short Name Inhibition, Motor neuron activity	0		Nov 29, 2016	Nov 29, 2016	None
1012	Increased, Inhibitory postsynaptic potential Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	3 AOPs 160: Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality 161: Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality 471: Neuron defect induced early behavioral change
1011	Increased, Chloride influx Short Name Increased, Chloride influx	0		Nov 29, 2016	Nov 29, 2016	None
1009	Inhibition, Deiodinase 1 Short Name Inhibition, Deiodinase 1	1	Molecular	Nov 29, 2016	Nov 18, 2025	3 AOPs 157: Deiodinase 1 inhibition leading to increased mortality via reduced posterior swim bladder inflation 158: Deiodinase 1 inhibition leading to increased mortality via reduced anterior swim bladder inflation 189: Type I iodothyronine deiodinase (DIO1) inhibition leading to altered amphibian metamorphosis