AOP-Wiki

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All Key Events

Showing 1551 to 1575 of 1921 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

718	Binding, Tubulin Short Name Binding, Tubulin	2	Molecular	Nov 29, 2016	Apr 20, 2021	106: Chemical binding to tubulin in oocytes leading to aneuploid offspring
716	Increase, cell proliferation (hepatocytes) Short Name	2	Cellular	Nov 29, 2016	Jan 6, 2021	3 AOPs 107: Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat 117: Androgen receptor activation leading to hepatocellular adenomas and carcinomas (in mouse and rat) 37: PPARα activation leading to hepatocellular adenomas and carcinomas in rodents
715	Activation, Constitutive androstane receptor Short Name	1	Molecular	Nov 29, 2016	Jun 28, 2018	107: Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat
714	Increased, Binding of chemicals to 2u (serum) Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	105: Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat)
713	Increase, Adenomas/carcinomas (renal tubular) Short Name	3	Tissue	Nov 29, 2016	Sep 16, 2017	2 AOPs 105: Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) 116: Cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat)
710	Increase, Regenerative cell proliferation (tubular epithelial cells) Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	2 AOPs 105: Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) 116: Cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat)
709	Increase, Cytotoxicity (renal tubular cell) Short Name	1	Cellular	Nov 29, 2016	Mar 3, 2022	5 AOPs 105: Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) 256: Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity 257: Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity 258: Renal protein alkylation leading to kidney toxicity 437: Inhibition of mitochondrial electron transport chain (ETC) complexes leading to kidney toxicity
708	Increased, Accumulation of alpha2u microglobulin (proximal tubular epithelium) Short Name	1	Tissue	Nov 29, 2016	Sep 16, 2017	105: Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat)
699	Increased, cardiac arrthymia Short Name Increased, cardiac arrthymia	1	Organ	Nov 29, 2016	Sep 16, 2017	104: Altered ion channel activity leading impaired heart function
698	Altered, Action Potential Short Name Altered, Action Potential	1	Cellular	Nov 29, 2016	Mar 31, 2022	4 AOPs 104: Altered ion channel activity leading impaired heart function 552: Inhibiton of L-Type Calcium Channels leading to heart failure via QT interval prolongation and Torsades de Pointes (TdP) 553: Inhibition of Voltage-gated sodium channels (Na⁺ channels) leading to heart failure 559: Inhibition of acetylcholinesterase (AChE) leading to arrhythmias
697	impaired, ion channels Short Name impaired, ion channels	2	Cellular	Nov 29, 2016	Dec 3, 2016	104: Altered ion channel activity leading impaired heart function
696	Increased, Chromosome misseggregation Short Name Increased, Chromosome misseggregation	1	Cellular	Nov 29, 2016	Sep 16, 2017	103: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint
695	Upregulated, Spindle assembly checkpoint protein Mad2-oocyte Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	103: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint
694	Reduced, Meiotic prophase I/metaphase I transition, oocyte Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	102: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition
693	Increased, cyclic adenosine monophosphate Short Name	1	Tissue	Nov 29, 2016	Dec 3, 2016	2 AOPs 102: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition 558: Phosphodiesterase inhibition leading to heart failure
692	Reduced, Maturation inducing steroid receptor signalling, oocyte Short Name	2	Tissue	Nov 29, 2016	Sep 16, 2017	2 AOPs 102: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition 103: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint
691	Reduced, Maturation inducing steroid, plasma Short Name	1	Tissue	Nov 29, 2016	Sep 16, 2017	2 AOPs 102: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition 103: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint
690	Reduced, Luteinizing hormone (LH), plasma Short Name	1	Tissue	Nov 29, 2016	Sep 16, 2017	2 AOPs 102: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition 103: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint
689	Reduced, Gonadotropin releasing hormone, hypothalamus Short Name	1	Tissue	Nov 29, 2016	Sep 16, 2017	2 AOPs 102: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition 103: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint
687	Reduced, Prostaglandin E2 concentration, hypothalamus Short Name	1	Tissue	Nov 29, 2016	Sep 16, 2017	2 AOPs 102: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition 103: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint
685	Reduced, Prostaglandins, ovary Short Name Reduced, Prostaglandins, ovary	1	Organ	Nov 29, 2016	Sep 16, 2017	63: Cyclooxygenase inhibition leading to reproductive dysfunction
682	Generation, Amplified excitatory postsynaptic potential (EPSP) Short Name	1	Cellular	Nov 29, 2016	May 18, 2018	10: Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain
681	Decreased, Prostaglandin F2alpha synthesis, ovary Short Name	1	Organ	Nov 29, 2016	Sep 16, 2017	101: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release
679	Decline, Population trajectory Short Name Decline, Population trajectory	1	Population	Nov 29, 2016	Dec 3, 2016	309: Luteinizing hormone receptor antagonism leading to reproductive dysfunction
678	Reduced, Pheromone release Short Name Reduced, Pheromone release	1	Individual	Nov 29, 2016	Dec 3, 2016	101: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release