AOP-Wiki

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All Key Events

Showing 1676 to 1700 of 1921 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

496	Increased apoptosis, decreased fetal/adult Leydig Cells Short Name Decreased Leydig Cells	1	Cellular	Nov 29, 2016	May 17, 2023	2 AOPs 64: Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility 476: Adverse Outcome Pathways diagram related to PBDEs associated male reproductive toxicity
495	Repressed expression of steroidogenic enzymes Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	2 AOPs 64: Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility 595: Emerging OPFRS reproductive outcome pathway
494	Glucocorticoid Receptor Agonist, Activation Short Name GR Agonist, Activation	1	Molecular	Nov 29, 2016	Sep 16, 2017	64: Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility
493	Increased, Insufficient repair or mis-repair of pro-mutagenic DNA adducts Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	46: AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC)
491	Clonal Expansion/Cell Proliferation, to form Altered Hepatic Foci (AHF) Short Name	1	Organ	Nov 29, 2016	Sep 16, 2017	46: AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC)
488	Decrease, Ovulation Short Name Decrease, Ovulation	1	Organ	Nov 29, 2016	Sep 16, 2017	63: Cyclooxygenase inhibition leading to reproductive dysfunction
486	systemic inflammation leading to hepatic steatosis Short Name inflammation	1	Organ	Nov 29, 2016	Feb 24, 2017	62: AKT2 activation leading to hepatic steatosis
484	Activation, AKT2 Short Name Activation, AKT2	1	Molecular	Nov 29, 2016	Sep 16, 2017	62: AKT2 activation leading to hepatic steatosis
483	Activation, LXR alpha Short Name Activation, LXR alpha	1	Molecular	Nov 29, 2016	Sep 16, 2017	61: NFE2L2/FXR activation leading to hepatic steatosis
482	Decreased, DHB4/HSD17B4 Short Name Decreased, DHB4/HSD17B4	1	Molecular	Nov 29, 2016	Sep 16, 2017	61: NFE2L2/FXR activation leading to hepatic steatosis
480	Activation, SHP Short Name Activation, SHP	1	Molecular	Nov 29, 2016	Sep 16, 2017	61: NFE2L2/FXR activation leading to hepatic steatosis
479	Activation, NR1H4 Short Name Activation, NR1H4	1	Molecular	Nov 29, 2016	Sep 16, 2017	61: NFE2L2/FXR activation leading to hepatic steatosis
478	Activation, NRF2 Short Name Activation, NRF2	1	Molecular	Nov 29, 2016	Sep 16, 2017	61: NFE2L2/FXR activation leading to hepatic steatosis
477	Decreased, Ketogenesis Short Name Decreased, Ketogenesis	1	Cellular	Nov 29, 2016	Sep 16, 2017	60: NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis
474	Down Regulation, HMGCS2 Short Name Down Regulation, HMGCS2	1	Molecular	Nov 29, 2016	Sep 16, 2017	60: NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis
472	Down Regulation, CPT1A Short Name Down Regulation, CPT1A	1	Molecular	Nov 29, 2016	Sep 16, 2017	2 AOPs 60: NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis 401: G protein-coupled estrogen receptor 1 (GPER) signal pathway in the lipid metabolism disrupting effects
471	Inhibition, FoxA2 Short Name Inhibition, FoxA2	1	Molecular	Nov 29, 2016	Sep 16, 2017	60: NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis
470	Up Regulation, Acetyl-CoA carboxylase-1 (ACC-1) Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	58: NR1I3 (CAR) suppression leading to hepatic steatosis
468	Inhibition, PPAR alpha Short Name Inhibition, PPAR alpha	1	Molecular	Nov 29, 2016	Sep 16, 2017	58: NR1I3 (CAR) suppression leading to hepatic steatosis
467	Increased, LDL uptake Short Name Increased, LDL uptake	1	Cellular	Nov 29, 2016	Sep 16, 2017	2 AOPs 57: AhR activation leading to hepatic steatosis 462: Activation of reactive oxygen species leading the atherosclerosis
466	Up Regulation, LDLR (low density lipoprotein receptor) Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	57: AhR activation leading to hepatic steatosis
465	Increased, Fatty acid influx Short Name Increased, FA Influx	1	Cellular	Nov 29, 2016	Feb 24, 2026	6 AOPs 57: AhR activation leading to hepatic steatosis 60: NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis 58: NR1I3 (CAR) suppression leading to hepatic steatosis 624: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction 625: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress 626: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated endoplasmic reticulum stress
463	Up Regulation, FAS Short Name Up Regulation, FAS	1	Molecular	Nov 29, 2016	Sep 16, 2017	58: NR1I3 (CAR) suppression leading to hepatic steatosis
462	Up Regulation, SCD-1 Short Name Up Regulation, SCD-1	1	Molecular	Nov 29, 2016	Sep 16, 2017	4 AOPs 58: NR1I3 (CAR) suppression leading to hepatic steatosis 60: NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis 57: AhR activation leading to hepatic steatosis 401: G protein-coupled estrogen receptor 1 (GPER) signal pathway in the lipid metabolism disrupting effects
461	Suppression, HNF4alpha Short Name Suppression, HNF4alpha	1	Molecular	Nov 29, 2016	Sep 16, 2017	59: HNF4alpha suppression leading to hepatic steatosis