Key Event Relationships (KERs)

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Showing 2751 to 2775 of 3102 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
1211 1146: premature, Spawning 1164: Increased, Population Nov 29, 2016 Dec 3, 2016 None
1222 1146: premature, Spawning 1141: Decreased, Reproductive Success Nov 29, 2016 Dec 3, 2016 None
1179 1144: premature, spawning 1 1141: Decreased, Reproductive Success Nov 29, 2016 Dec 3, 2016 None
3708 2400: Preputial epithelial morphogenesis, disrupted 2401: Male PPS, failed/delayed Dec 16, 2025 Dec 16, 2025
1283 1234: Production of nerve growth factor , Epithelial irritation 1222: SP (Substance P) release, Local increase of SP Nov 29, 2016 Dec 3, 2016 None
1358 1274: Production of α-smooth muscle actin 1276: Lung fibrosis Feb 15, 2017 Feb 15, 2017 None
93 77: Production, Critical Metabolites (CGA 330050 and CGA 265307) 164: Induction, Liver “Dysfunctional” Changes by CGA 330050 Nov 29, 2016 Dec 3, 2016
332 302: Production, VEGF-A 301: Binding, VEGF-A Nov 29, 2016 Dec 3, 2016 None
333 302: Production, VEGF-A 304: Decreased, VegfR2 Nov 29, 2016 Dec 3, 2016 None
69 57: Proliferation, Cell proliferation in the absence of cytotoxicity 142: Hyperplasia, Hyperplasia Nov 29, 2016 Dec 3, 2016
1105 1067: Proliferation/Clonal Expansion, aberrant basal-type cells 1068: Endometrial squamous metaplasia, Increase Nov 29, 2016 Dec 3, 2016 None
1082 1042: Proliferation/Clonal Expansion, smooth muscle 1043: Hypertrophy/hyperplasia, smooth muscle Nov 29, 2016 Dec 3, 2016
2540 1961: Prolongation of Action Potential 1962: Prolongation of QT interval Dec 13, 2021 Dec 13, 2021
3411 1961: Prolongation of Action Potential 2283: Early premature depolarizations Nov 21, 2024 Nov 21, 2024
2541 1962: Prolongation of QT interval 1963: Torsades de Pointes Dec 13, 2021 Dec 13, 2021
2853 1962: Prolongation of QT interval 1106: Occurrence, cardiac arrhythmia Jan 29, 2023 Jan 29, 2023 None
3420 1962: Prolongation of QT interval 2283: Early premature depolarizations Nov 21, 2024 Nov 21, 2024
2429 1842: TLR9 activation 1897: MyD88 activation Jul 8, 2021 Jul 8, 2021
2433 1842: TLR9 activation 1895: inflammasome activity, increased Jul 8, 2021 Jul 8, 2021
604 599: prolonged, Depolarization of neuronal membrane 600: Overactivation, Neuronotransmitter release Nov 29, 2016 Dec 3, 2016
1098 1061: prolonged, elevation of serun CCK 1062: Increased, Cellular proliferation / hyperplasia of acinar cells Nov 29, 2016 Dec 3, 2016
1111 1075: prolonged, estrus cycle 1076: Increased, circulating estrogen levels Nov 29, 2016 Dec 3, 2016
1112 1075: prolonged, estrus cycle 1077: Increased, prolactin exposure Nov 29, 2016 Dec 3, 2016
2829 1053: Promotion, ovarian adenomas 2092: Promotion, Ovarian Cancer Jan 13, 2023 Mar 11, 2023
2830 1054: Promotion, ovarian granular cell tumors 2092: Promotion, Ovarian Cancer Jan 13, 2023 Jan 13, 2023 None