Key Event Relationships (KERs)

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Showing 801 to 825 of 3102 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
2735 2044: Decrease, SMO relocation 2028: Decrease, GLI1/2 translocation Aug 23, 2022 Apr 2, 2025
2732 2043: Decrease, SHH second messenger production 1821: Decrease, Cell proliferation Aug 23, 2022 Apr 3, 2025
2733 2043: Decrease, SHH second messenger production 1365: Increase, Apoptosis Aug 23, 2022 Aug 23, 2022 None
2957 2043: Decrease, SHH second messenger production 1262: Apoptosis Jun 29, 2023 Jun 29, 2023
3060 2197: Decrease, sox10 352: N/A, Neurodegeneration Oct 17, 2023 Oct 17, 2023
2685 2020: Decrease, sox9 expression 1559: Smaller and morphologically distorted facial cartilage structures Jun 30, 2022 Oct 20, 2022
2691 2020: Decrease, sox9 expression 317: Altered, Cardiovascular development/function Jun 30, 2022 Oct 20, 2022
436 266: Decrease, Steroidogenic acute regulatory protein (STAR) 447: Reduction, Cholesterol transport in mitochondria Nov 29, 2016 Apr 8, 2025
1547 1382: Decrease, surfactant 1405: Reduced, mucosal defense Jun 2, 2017 Jun 2, 2017
1888 1622: Decrease, Transgenerational DNA methylation 1621: Increase, Gene expression Apr 22, 2019 Apr 22, 2019 None
399 289: Decrease, Translocator protein (TSPO) 413: Reduction, Testosterone synthesis in Leydig cells Nov 29, 2016 Dec 3, 2016 None
437 289: Decrease, Translocator protein (TSPO) 447: Reduction, Cholesterol transport in mitochondria Nov 29, 2016 Dec 2, 2016
2098 1772: Decrease, TAG 1771: Decrease, ATP pool Apr 30, 2020 Apr 30, 2020
2744 2051: Decrease, Tyrosine 2052: Decrease, dopa decarboxylase Aug 28, 2022 Aug 28, 2022
3678 2384: Decrease, Vascular integrity 2383: Increase, Hemopericardium Oct 30, 2025 Oct 30, 2025
3216 450: Decrease, VLDL export capacity 459: Increase, Liver steatosis May 9, 2024 May 9, 2024
3515 2318: Decreased 3βHSD activity 1611: Reduction, androstenedione Apr 8, 2025 Apr 8, 2025 None
3516 2318: Decreased 3βHSD activity 1693: Decreased, Progesterone levels Apr 8, 2025 Apr 8, 2025 None
3497 2309: FAM50B/PTCHD3 methylation 2310: FAM50B/PTCHD3 expression Mar 2, 2025 Mar 2, 2025
3502 2309: FAM50B/PTCHD3 methylation 2121: decreased, IQ Mar 2, 2025 Mar 2, 2025
1618 1452: decreased DNA methylation of tyrosine hydroxylase 1447: obesity Jul 24, 2017 Jul 24, 2017
1620 1452: decreased DNA methylation of tyrosine hydroxylase 1450: decreased dopamine Jul 24, 2017 Jul 24, 2017
1614 1450: decreased dopamine 1451: decreased reward Jul 24, 2017 Jul 24, 2017
2700 2026: decrease folate 1561: Neural tube defects Jul 19, 2022 Jul 19, 2022
1814 1571: Decreased IL-1 production 1572: Impaired IL-1 signaling Dec 25, 2018 Jun 25, 2019 None