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Showing 1301 to 1325 of 3102 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

574	568: impaired, Hive thermoregulation	563: Death/Failure, Colony	Nov 29, 2016	Dec 3, 2016	2 AOPs 84: Suppression of immune system contributes to impaired development and leads to colony loss/failure 80: Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure
1153	568: impaired, Hive thermoregulation	1107: Weakened, Colony	Nov 29, 2016	Dec 3, 2016	1 AOP 79: Nicotinic acetylcholine receptor activation contributes to impaired hive thermoregulation and leads to colony loss/failure
701	697: impaired, ion channels	698: Altered, Action Potential	Nov 29, 2016	Dec 3, 2016	1 AOP 104: Altered ion channel activity leading impaired heart function
563	566: impaired, Larval development	563: Death/Failure, Colony	Nov 29, 2016	Dec 3, 2016	4 AOPs 82: Abnormal role change in worker caste contributes to reduced brood care and leads to colony loss/failure 86: Decrease Glucose oxidase activity contributes to reduction of antiseptic in food and leads to colony loss/failure 90: Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2 78: Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1
3460	566: impaired, Larval development	2302: Increase, Malformations	Dec 24, 2024	Dec 24, 2024	1 AOP 564: DBDPE-induced inhibition of mitochondrial complex Ⅰ leading to population decline via neurotoxicity and metabotoxicity.
3079	637: impaired, Learning and memory	896: Parkinsonian motor deficits	Oct 17, 2023	Oct 17, 2023	1 AOP 471: Neuron defect induced early behavioral change
2632	1989: Impaired, Oocyte maturation and ovulation	1990: Increased, Oocyte Atresia	Apr 5, 2022	Apr 5, 2022	1 AOP 445: Estrogen Receptor Alpha Agonism leads to Impaired Reproduction
2164	1758: Impaired, Spermatogenesis	330: Decrease, Fertility	Jul 13, 2020	Jul 13, 2020	None
2274	1758: Impaired, Spermatogenesis	406: decreased, Fertility	Jan 29, 2021	Aug 15, 2022	1 AOP 348: Inhibition of 11β-Hydroxysteroid Dehydrogenase leading to decreased population trajectory
2692	1758: Impaired, Spermatogenesis	2032: Viable offspring, decreased	Jul 18, 2022	Jul 18, 2022	None
2937	1758: Impaired, Spermatogenesis	2147: Decreased, Viable Offspring	Jun 2, 2023	Sep 29, 2023	2 AOPs 323: PPARalpha Agonism Leading to Decreased Viable Offspring via Decreased 11-Ketotestosterone 521: Essential element imbalance leads to reproductive failure via oxidative stress
3621	1758: Impaired, Spermatogenesis	520: Decreased sperm quantity or quality in the adult, Decreased fertility	Sep 3, 2025	Sep 3, 2025	1 AOP 595: Emerging OPFRS reproductive outcome pathway
3622	1758: Impaired, Spermatogenesis	1863: Decrease, Reproduction	Sep 3, 2025	Sep 3, 2025	1 AOP 595: Emerging OPFRS reproductive outcome pathway
665	583: impaired, Thoracic shivering	568: impaired, Hive thermoregulation	Nov 29, 2016	Dec 3, 2016	None
3173	2213: Impaired, urethral tube closure	2082: Hypospadias	Mar 20, 2024	Dec 3, 2024	1 AOP 527: Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) leads to Hypospadias, increased
125	110: Impairment, Endothelial network	298: Insufficiency, Vascular	Nov 29, 2016	Jan 18, 2022	1 AOP 43: Disruption of VEGFR Signaling Leading to Developmental Defects
976	110: Impairment, Endothelial network	317: Altered, Cardiovascular development/function	Nov 29, 2016	Jun 9, 2017	1 AOP 150: Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF
564	341: Impairment, Learning and memory	564: Abnormal, Roll change within caste	Nov 29, 2016	Dec 3, 2016	2 AOPs 90: Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2 78: Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1
583	341: Impairment, Learning and memory	560: Abnormal, Foraging activity and behavior	Nov 29, 2016	Dec 3, 2016	4 AOPs 87: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure 77: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1 89: Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure 88: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste
1644	341: Impairment, Learning and memory	635: Decreased, locomotion	Aug 11, 2017	Aug 11, 2017	1 AOP 99: Histamine (H2) receptor antagonism leading to reduced survival
2872	341: Impairment, Learning and memory	2121: decreased, IQ	Apr 4, 2023	Apr 4, 2023	1 AOP 490: Co-activation of IP3R and RyR leads to reduced IQ and increased socio-economic burden through non-cholinergic mechanisms
1446	1328: Inactivated, 5-HTR	1329: Reduce expression, BDNF	Apr 14, 2017	Apr 14, 2017	3 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 225: Serotonin transporter activation to agitation 224: Serotonin transporter activation to depression
1511	1328: Inactivated, 5-HTR	1335: Reduced, BDNF	May 30, 2017	May 30, 2017	1 AOP 222: Mental stress to agitation
1353	1270: Inactivation of PPARγ	1271: Activation of TGF-β signaling	Feb 15, 2017	Feb 15, 2017	1 AOP 206: Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis
2156	1270: Inactivation of PPARγ	1283: Activation, TGF-beta pathway	Jul 9, 2020	Jul 9, 2020	1 AOP 347: Toll-like receptor 4 activation and peroxisome proliferator-activated receptor gamma inactivation leading to pulmonary fibrosis

Key Event Relationships (KERs)

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